Novel simultaneous method for the determination of avobenzone and oxybenzone in human plasma by UHPLC-MS/MS with phospholipid removal pretreatment: An application to a sunscreen clinical trial

Pilli, Nageswara Rao; Narayanasamy, Suresh; Florian, Jeffry; Zusterzeel, Robbert; Patel, Vikram; Strauss, David G.; Matta, Murali K.

doi:10.1016/j.jchromb.2021.122615

Cited by 6 publications

(4 citation statements)

References 16 publications

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“…Several cosmetic products have been developed to protect from the harmful effects of solar radiation, meanwhile, the chemical used to reduce the impact of solar radiation also have negative effects on the environment causing coral bleaching and toxic for other marine species. Also, it has been reported that is oxybenzone, the active ingredient in sunscreens, is able to permeate the skin by follicular conduct and achieve vascular system inducing inflammatory effects [1] , [2] , [3] , [4] , [5] , [6] .…”

Section: Introductionmentioning

confidence: 99%

Microalgae growth rate multivariable mathematical model for biomass production

Martínez-Ruiz

Vazquez

Losoya

et al. 2023

Heliyon

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Section: Introductionmentioning

confidence: 99%

Microalgae growth rate multivariable mathematical model for biomass production

Martínez-Ruiz

Vazquez

Losoya

et al. 2023

Heliyon

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“…Results from these studies were published in the Journal of the American Medical Association: JAMA ( 7 , 8 ), one of which was the most viewed JAMA article in 2019 ( 8 ). DARS also published the detailed bioanalytical method it developed ( 9 ) to enable further study and collaborated with FDA’s Office of Pharmaceutical Quality staff on a study to assess sunscreen ingredient absorption with an in vitro model ( 10 ).…”

Section: Emergent Regulatory and Public Health Questionsmentioning

confidence: 99%

New science, drug regulation, and emergent public health issues: The work of FDA’s division of applied regulatory science

et al. 2023

Self Cite

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The U.S. Food and Drug Administration (FDA) Division of Applied Regulatory Science (DARS) moves new science into the drug review process and addresses emergent regulatory and public health questions for the Agency. By forming interdisciplinary teams, DARS conducts mission-critical research to provide answers to scientific questions and solutions to regulatory challenges. Staffed by experts across the translational research spectrum, DARS forms synergies by pulling together scientists and experts from diverse backgrounds to collaborate in tackling some of the most complex challenges facing FDA. This includes (but is not limited to) assessing the systemic absorption of sunscreens, evaluating whether certain drugs can convert to carcinogens in people, studying drug interactions with opioids, optimizing opioid antagonist dosing in community settings, removing barriers to biosimilar and generic drug development, and advancing therapeutic development for rare diseases. FDA tasks DARS with wide ranging issues that encompass regulatory science; DARS, in turn, helps the Agency solve these challenges. The impact of DARS research is felt by patients, the pharmaceutical industry, and fellow regulators. This article reviews applied research projects and initiatives led by DARS and conducts a deeper dive into select examples illustrating the impactful work of the Division.

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“…Consequently, the accumulation of sunscreen pollution potentially threatens the integrity of near-shore habitats and ecosystems in vicinity of popular beaches resulting in acute and chronic toxicity to aquatic invertebrate and fish species . Additionally, the absorption, bioaccumulation, and biomagnification of UV filters like avobenzone in fish and other organisms has been detected in human plasma and urine and associated with seafood consumption. AVO, octocrylene, EHMC, and HMS were indicated as potential endocrine disruptors by Nemeth et al…”

Section: Introductionmentioning

confidence: 99%

Biodegradation Rates of Ferulic Acid Derivatives and Traditional Sunscreen Actives in Marine, Bay, and Freshwater Environments

Chou,

McCaffrey,

Klamczynski

et al. 2024

ACS Sustainable Chem. Eng.

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In recent years, concern over adverse effects of conventional organic ultraviolet (UV) absorbers on human and environmental health has grown. In particular, the time frame that such compounds are expected to remain in the environment is a topic of interest. In this work, the mineralization rates of traditional sunscreen actives octinoxate (EHMC), homosalate (HMS), and avobenzone (AVO) were compared to bioderived UV absorbers ferulic acid (FA), ethyl ferulate (ETF), feruloylated soybean oil (FSO), and feruloylated coconut oil (FCO). These rates were determined by observing CO 2 generation over time under three separate nutrient-supplemented, environment-like conditions: marine water, bay water, and freshwater. The effect of nutrient supplementation was also separately estimated through comparing mineralization rates of supplemented with nonsupplemented freshwater. The resulting mineralization rates and projected half-lives of these compounds were then compared with previous experiments performed in wastewater treatment sludge, as well as with biodegradation properties predicted by quantitative structure−activity/property relationship (QSAR) models. Across all three aquatic environments, we observed that the ferulic acid derivatives (FA, ETF, FSO, and FCO) mineralized faster than conventional UV absorbers (EHMC, HMS, AVO) by 1 to 2 orders of magnitude.

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Novel simultaneous method for the determination of avobenzone and oxybenzone in human plasma by UHPLC-MS/MS with phospholipid removal pretreatment: An application to a sunscreen clinical trial

Cited by 6 publications

References 16 publications

Microalgae growth rate multivariable mathematical model for biomass production

Microalgae growth rate multivariable mathematical model for biomass production

New science, drug regulation, and emergent public health issues: The work of FDA’s division of applied regulatory science

Biodegradation Rates of Ferulic Acid Derivatives and Traditional Sunscreen Actives in Marine, Bay, and Freshwater Environments

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