337. Copper(II), cobalt(II), and nickel(II) complexes of various antihistaminic compounds: their stability and thermodynamic values

Andrews, A. C.; Lyons, T. D.

doi:10.1039/jr9620001776

Cited by 24 publications

(7 citation statements)

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“…5 In fact, the anti-Hm activity of certain compounds depends upon their competition with Hm for binding receptor sites, which in some cases were shown to be metal ions. 6 It has also been suggested that the copper complexes of Hm and salicylates are potential antiinflammatory drugs. 7 In addition, the interaction of metallic cations with Hm itself is also of interest because a better understanding of the coordination mode of a small imidazole-containing ligand like Hm may help in clarifying the coordination ability of the peptide linkage and the role of the N donor atom in the binding.…”

Section: Introductionmentioning

confidence: 99%

Raman and IR study on copper binding of histamine

et al. 2003

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A comparative Raman and FTIR study of histamine (Hm), a small hormone present in a wide selection of living organisms, and its complexes with copper(II) at different pH values was carried out. Both the Raman and IR spectra present some marker bands useful for the identification of the structure of the species predominating in the Cu(II) aqueous and alcoholic systems. In particular, Raman spectroscopy appears to be a useful tool for analyzing the tautomeric equilibrium of the imidazole ring of Hm, because some bands (i.e., nuC(4)dbond;C(5)) appear at different wavenumbers, depending on whether the imidazole moiety is in the N(tau)-H (tautomer I) or N(pi)-H (tautomer II) protonated form. In aqueous solutions the manner in which Hm binds to Cu(II) depends on the pH. At basic pH the most relevant species formed are a dimer, [Cu(2)L(2)H(-2)](2+), and a monomeric complex, [CuL](2-) or [CuL(2)](+). On the contrary, by decreasing the pH, Hm acts as a mono- or bidentate ligand, giving rise to two types of monomeric complexes, [CuLH](2-) and [CuL](2-) or [CuL(2)](+). With respect to the Cu(II)-Hm alcoholic system, both the aminic group and the imidazole ring (tautomer I) take part in the Cu(II) coordination, leading to the formation of the [CuL](2-) or [CuL(2)](+) monomeric complex.

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Section: Introductionmentioning

confidence: 99%

Raman and IR study on copper binding of histamine

et al. 2003

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“…Being the nickel of biological importance, its complexation with bioactive ligands is worth to be studied with the aim to understand functions of its complexes and to explore new bioactive compounds . The bioinorganic role of nickel and the bioavailability in its dependent enzymes such as in urease, E. coli glyoxalase I, [NiFe]‐hydrogenase, methyl‐CoM reductase, CO dehydrogenase, and acetyl coenzyme A synthase, is widely recognized . The structure of nickel proteins has greatly explored by means of the X‐ray crystallography .…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis and X‐ray structural studies of novel [acetonitrile‐benzyl‐3‐N‐(2, 4 dihydroxyphenylmethylene) hydrazinecarbodithioato‐κ3‐N′, S, O] nickel(ll) complex that potently inhibit cell proliferation through regulation of apoptosis related genes

Zahan

Rahi

Sheikh

et al. 2018

Applied Organom Chemis

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Nickel is a fundamental element for healthy life for human and higher animals. For biological importance, its complexation with bioactive ligand is worth to be studied with the aim to understand its function. Using mouse peritoneal cancer model, MTT colorimetric assay and anticancer activity analysis, we examined the role of nickel(ll) complex in growth inhibition of cancer cells. A novel nickel(ll) complex was synthesized and characterized using physico‐chemical and spectroscopic techniques. The study indicated that both the ligand and complex were capable of inhibiting Ehrlich Ascites Carcinoma (EAC) cells growth by 28.21% and 44.52%, respectively, when administered 0.3 mg/kg/day body weight intraperitoneally for five consecutive days in Swiss Webstar mice. Determination the LD50 of the complex (55 mg/kg) allowed adjusting the dose as 2.75 mg/kg and upon administration, inhibition increased to 69.36%. The ligand and complex have shown an inhibitory effect in the range of 4.86%–67.3% and 6.1%‐ 89.37%, respectively, against EAC cells (concentration range of 31.25–500 μg/ml) in RPMI‐1640 medium as determined by MTT colorimetric assay. Apoptotic cell morphological alteration was determined through optical and fluorescence microscopy. Up regulation of P53, Bax, Cas‐8, Cas‐3 and Fas and down regulation of NF‐kB and Bcl‐2 gene expression were observed in the cells treated with the nickel(ll) complex for five consecutive days. In conclusion, the newly synthesized nickel(ll) complex has shown anti‐proliferative activity and can further be optimized to be used as a lead molecule for anticancer drug.

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“…the regulation of micro-circulation and blood pressure, the stimulation of gastric secretion, the mediation of symptoms of allergy and inflammation, etc. ; use in pharmacology makes it an attractive field for biochemical researchers [28]. Therefore, the present complexes of imidazole derivatives may be of interest in pharmacological studies.…”

Section: Introductionmentioning

confidence: 99%

Polymeric nickel(II) squarate complexes with imidazole derivatives: syntheses, crystal structures, spectroscopic and voltammetric studies

Uçar

2008

Journal of Coordination Chemistry

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337. Copper(II), cobalt(II), and nickel(II) complexes of various antihistaminic compounds: their stability and thermodynamic values

Cited by 24 publications

References 0 publications

Raman and IR study on copper binding of histamine

Raman and IR study on copper binding of histamine

Design, synthesis and X‐ray structural studies of novel [acetonitrile‐benzyl‐3‐N‐(2, 4 dihydroxyphenylmethylene) hydrazinecarbodithioato‐κ3‐N′, S, O] nickel(ll) complex that potently inhibit cell proliferation through regulation of apoptosis related genes

Polymeric nickel(II) squarate complexes with imidazole derivatives: syntheses, crystal structures, spectroscopic and voltammetric studies

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