Preoperative prognostic nutritional index predicts prognosis of patients with oral cavity cancer

Abstract

Objective To investigate whether prognostic nutritional index (PNI) predicts patient survival outcomes in oral cavity squamous cell carcinoma (OSCC). Materials and methods The data of a total of 360 patients subjected to primary surgery for OSCC were retrospectively analysed. Patients were categorised into high‐PNI (≥51.75) and low‐PNI (<51.75) groups based on the PNI cut‐off value attained from receiver operating characteristic analyses (p < .001), and the intergroup differences in clinicopathological features were determined. The Kaplan–Meier method and Cox proportional hazard model were employed to determine the survival prediction ability of the PNI, and a nomogram based on the PNI was established for individualised survival prediction. Results A low PNI was noted to exhibit a significant association with shorter overall survival (OS) and disease‐free survival (DFS) (both p < .001). Multivariate Cox analyses showed that a lower PNI independently indicated shorter OS and DFS (hazard ratio [HR] = 2.187; p = .001 and HR = 1.459; p = .023, respectively). The concordance index and calibration plots of the PNI‐based nomogram revealed the high discriminative ability for OS. Conclusions Preoperative PNI is a valuable biomarker for predicting OSCC prognosis, and the proposed PNI‐based nomogram can provide individualised prognostic prediction.

Prognostic Nutritional Index in Patients With End-Stage Oral Cancer

“…In addition, poor nutritional status causes a decrease in TLC and T cell count, suggesting an immune impairment or a progressive inflammatory response, reflecting the reduced function of NEUs due to inadequate protein intake and susceptibility to infection. 11,[15][16][17][18][19] However, multiple regression analysis showed no significant differences. This may be due, in part, to the small sample size.…”

Prognostic and clinicopathological significance of prognostic nutritional index (PNI) in patients with oral cancer: a meta-analysis

“…Subsequently, 10 of them were discarded due to the fact that no survival data provided (n=5), not on oral cancer (n=3), and not reported on PNI (n=2). Finally, ten studies with 3,130 patients [12,13,[20][21][22][23][24][25][26][27] were enrolled in the present meta-analysis (Figure 1).…”

“…Table 1 demonstrates the baseline traits for the enrolled studies [12,13,[20][21][22][23][24][25][26][27]. The years of publication ranged between 2020-2022 for these studies.…”

“…Eight studies were published in English language [12, 13, 20-22, 24, 25, 27] and two in Chinese [23,26]. All studies [12,13,[20][21][22][23][24][25][26][27] were of retrospective design. Overall sample size was 3,130, varying between 47-1,395.…”

“…Previous studies have reported that low PNI played a prognostic role in diverse carcinomas, such as esophageal squamous cell carcinomas [15], gastrointestinal stromal tumors [16], hepatocellular carcinoma [17], non-small cell lung cancer [18], and glioma [19]. Many studies [12,13,[20][21][22][23][24][25][26][27] have investigated PNI's prognostic significance to oral cancer prognosis as well. However, the results were not consistent.…”