Helicobacter pylori infection rates in dyspeptic Serbian HIV-infected patients compared to HIV-negative controls

Spurnić, Aleksandra Radovanović; Bukumirić, Zoran; Jevtović, Djordje; Brmbolic, Branko; Pekmezovic, Tatiana; Salemović, Dubravka; Pavlović, Ivana; Milošević, Ivana; Ranin, Jovan; Korać, Marija

doi:10.1371/journal.pone.0248041

Cited by 5 publications

(5 citation statements)

References 33 publications

(13 reference statements)

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“…pylori infection is often considered a disease of poverty as it is associated with poor hygiene and sanitation conditions and is more prevalent in low-income and developing countries where HIV infection is rampant. We found that H. pylori infection rate was higher in HIV-positive patients compared to HIV-negative controls although several other studies reported a lower H. pylori infection prevalence in HIV-positive patients than HIV-negative individuals [11][12][13][14]. The present study investigated the effect of H. pylori infection on CD4 + T cell counts and HIV viral load levels, which are the most important and widely used predictors of progression to AIDS [22], among people infected with HIV in a high co-endemic setting.…”

Section: Discussionmentioning

confidence: 52%

“…pylori co-infections may affect the course of HIV disease progression. H. pylori infection is common in HIV-positive patients, especially in developing countries where both infections are prevalent, although there are conflicting findings on the prevalence of H. pylori infection in HIVpositive patients compared to HIV-negative individuals [11][12][13][14][15][16][17]. H. pylori is a bacterium that can colonize the lining of the gastric and duodenal mucosa and has been associated with a range of gastrointestinal diseases, including gastritis and ulcers [18].…”

Section: Introductionmentioning

confidence: 99%

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CD4+ T cell count and HIV-1 viral load dynamics positively impacted by H. pylori infection in HIV-positive patients regardless of ART status in a high-burden setting

Abadi,

Teklu,

Wondmagegn

et al. 2024

Eur J Med Res

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Background There is a widespread co-infection of HIV and Helicobacter pylori (H. pylori) globally, particularly in developing countries, and it has been suggested that this co-infection may affect the course of HIV disease. However, the interplay between H. pylori infection and HIV disease progression is not fully elucidated. In this study, we investigated the effect of H. pylori co-infection on CD4+ T cell count and HIV viral load dynamics in HIV-positive individuals in a high co-endemic setting. Methods A comparative cross-sectional study was conducted among 288 HIV-positive and 175 HIV-negative individuals, both with and without H. pylori infection. Among HIV-positive participants, 195 were on antiretroviral therapy (ART) and 93 were ART-naïve. CD4+ T cell count and HIV-1 viral load were measured and compared between H. pylori-infected and -uninfected individuals, taking into account different HIV and ART status. Result Our study demonstrated that individuals infected with H. pylori had a significantly higher CD4+ T cell count compared to uninfected controls among both HIV-negative and HIV-positive participants, regardless of ART therapy. Conversely, HIV/H. pylori co-infected participants had lower HIV-1 viral load than those without H. pylori infection. Linear regression analysis further confirmed a positive association between H. pylori infection, along with other clinical factors such as BMI, ART, and duration of therapy, with CD4+ T cell count while indicating an inverse relationship with HIV-1 viral load in HIV-positive patients. Additionally, factors such as khat chewing, age and WHO clinical stage of HIV were associated with reduced CD4+ T cell count and increased HIV-1 viral load. Conclusion Our study demonstrates that H. pylori co-infection was associated with higher CD4+ T cell count and lower HIV-1 viral load in HIV-positive patients, regardless of ART status. These findings show a positive effect of H. pylori co-infection on the dynamics of HIV-related immunological and virological parameters. Further studies are needed to elucidate the underlying mechanisms of the observed effects.

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Section: Discussionmentioning

confidence: 52%

Section: Introductionmentioning

confidence: 99%

CD4+ T cell count and HIV-1 viral load dynamics positively impacted by H. pylori infection in HIV-positive patients regardless of ART status in a high-burden setting

Abadi,

Teklu,

Wondmagegn

et al. 2024

Eur J Med Res

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“…However, previous reports using either H. felis or H. pylori have demonstrated that immunodeficient SCID mice had increased colonization compared to WT mice ( Blanchard et al, 1995 ; Eaton et al, 1999 ; Nedrud et al, 2012 ). Additionally, no difference in bacterial load has been observed in HIV positive and negative patients despite the significance differences in host immune response ( Spurnic et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

The TNF-Alpha Inducing Protein is Associated With Gastric Inflammation and Hyperplasia in a Murine Model of Helicobacter pylori Infection

et al. 2022

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Helicobacter pylori (H. pylori) is a Gram-negative bacterium that colonizes the human stomach leading to the development of chronic gastritis, peptic ulcers and gastric adenocarcinoma. A combination of host, environment and bacterial virulence factors contribute to disease development. The H. pylori TNFα inducing protein (Tipɑ) is a virulence factor shown to induce multiple pro-inflammatory cytokines in addition to TNFα in vitro. The goal of the present study was to elucidate the role of Tipα in promoting inflammation in vivo and to identify the molecular pathways associated with Tipα associated virulence. Mice were infected with wild-type Sydney strain (SS1) or a tipα mutant (Δtipα) for 1 month and 4 months. We also completed a second 4 months infection including a 1:1 SS1 to Δtipα co-infected group in addition to SS1 and Δtipα infected groups. The expression of TNFα, and KC were significantly higher in the SS1 infected group compared to both uninfected control (naïve) and Δtipα groups. Mice infected with Tipα expressing SS1 induced more severe histological gastritis and developed hyperplasia compared to Δtipα infected mice. Microarray analysis of gastric epithelial cells co-cultured with recombinant Tipα (rTipα) demonstrates up-regulation of the NFκB pathway. This data suggest Tipα plays an important role in H. pylori induced inflammation.

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“…In a study of Radovanovic Spurnic et al (2021) the prevalence of Helicobacter pylori infection in Central Serbia was significantly higher in HIV-negative controls than in in people living with HIV (50.2% vs. 28.1%). The prevalence of Helicobacter pylori infection in Central Serbia is still unknown [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…Chronic Helicobacter pylori infection is a significant risk factor and increases the risk for developing stomach cancer within ten years of infection 5.9 times [ 16 ]. There are no available data for Helicobacter pylori chronic infection prevalence in the Republic of Serbia [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Trends of Stomach Cancer in Central Serbia

et al. 2021

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Somach cancer is the third most common cause of cancer-related deaths worldwide. The objective of the paper was to analyze the incidence and mortality trends of stomach cancer in Central Serbia in the period between 1999–2017. Materials and Methods: trends and annual percentage change (APC) of the incidence and mortality rate with corresponding 95% confidence intervals (CI) were calculated by joinpoint regression analyses. The optimal number of Joinpoints was identified using the Monte Carlo permutation method. The trend was considered to be significantly increasing (positive change) or decreasing (negative change) when the p-value was below 0.05 (p < 0.05). Results: the total number of new cases was 16,914 (10,873 males and 6041 females) and the total number of mortality cases was 14,790 (9348 in and 5442 in females). Almost one third (30.8%) of new cases were registered in the 60–69-year age group, and new cases were significantly more frequent in males than in females (30.8% vs. 29.02%, p < 0.001). Joinpoint regression analysis showed a significant decrease of incidence trend in females during the 2000–2015 period with APC of −2.13% (95% CI: −3.8 to −0.5, p < 0.001). An insignificant decrease in incidence trend was in males with APC of −0.72% (95% CI: −2.3 to 0.9, p = 0.30). According to the joinpoint analysis, a significant decrease of mortality trends both in males during 2000–2015 with APC of −2.21% (95% CI: −1.6 to −7.5, p ≤ 0.001 and in females, during the same period, with APC of −1.75% (95% CI: −2.9 to −0.6, p < 0.001) was registered. From 2015 to 2017, a significant increase of mortality was registered with APC of 44.5% (95% CI: from 24.2 to −68.1, p ≤ 0.001) in females and in males with APC of 53.15% (95% CI: 13.5 to −106.6, p ≤ 0.001). Conclusion: a significant decrease of stomach cancer incidence trend in females and insignificant decrease of incidence trend in males were determined in Central Serbia. Based on presented results, the mortality trend decreased significantly both in males and in females during 2000–2015, and from 2015 to 2017 we recorded a significant increase in mortality in both sexes. We found significantly more new cases in women than in men in the age group of 40–49, and the mortality of stomach cancer was significantly more frequent among females compared to males in the age groups 30–39, as well as in the 50–59 age group. There is a need for improving recording and registration of new cases of stomach cancer, especially in females. Urgent primary and secondary preventive measures are needed—introducing stomach cancer screening and early detection of premalignant changes. Urgent primary and secondary preventive measures are needed.

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Helicobacter pylori infection rates in dyspeptic Serbian HIV-infected patients compared to HIV-negative controls

Cited by 5 publications

References 33 publications

CD4+ T cell count and HIV-1 viral load dynamics positively impacted by H. pylori infection in HIV-positive patients regardless of ART status in a high-burden setting

CD4+ T cell count and HIV-1 viral load dynamics positively impacted by H. pylori infection in HIV-positive patients regardless of ART status in a high-burden setting

The TNF-Alpha Inducing Protein is Associated With Gastric Inflammation and Hyperplasia in a Murine Model of Helicobacter pylori Infection

Trends of Stomach Cancer in Central Serbia

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