Hybrid Nanoparticles Modified by Hyaluronic Acid Loading an HSP90 Inhibitor as a Novel Delivery System for Subcutaneous and Orthotopic Colon Cancer Therapy

Pan, Chen‐Wei; Zhang, Tiaotiao; Li, Shaoxun; Xu, Zhihua; Pan, Binhui; Xu, Shaohua; Jin, Shuanghong; Lu, Guangrong; Yang, Shou‐Xing; Xue, Zhanxiong; Chen, Ping; Shen, Xian; Wang, Fangyan; Xu, Chunyan

doi:10.2147/ijn.s275805

Cited by 11 publications

(11 citation statements)

References 37 publications

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“…As an original strategy, Pan et al reported hyaluronic acid-decorated hybrid PLGA nanoparticles as 17-allylaminogeldanamycin delivery carriers for targeted colon cancer therapy. In vivo studies showed much better therapeutic efficiency than the free therapeutic [ 51 ].…”

Section: From Raw Materials To Polymeric Npsmentioning

confidence: 99%

Polyester Polymeric Nanoparticles as Platforms in the Development of Novel Nanomedicines for Cancer Treatment

Niza

Ocaña

Castro‐Osma

et al. 2021

Cancers

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Many therapeutic agents have failed in their clinical development, due to the toxic effects associated with non-transformed tissues. In this context, nanotechnology has been exploited to overcome such limitations, and also improve navigation across biological barriers. Amongst the many materials used in nanomedicine, with promising properties as therapeutic carriers, the following one stands out: biodegradable and biocompatible polymers. Polymeric nanoparticles are ideal candidates for drug delivery, given the versatility of raw materials and their feasibility in large-scale production. Furthermore, polymeric nanoparticles show great potential for easy surface modifications to optimize pharmacokinetics, including the half-life in circulation and targeted tissue delivery. Herein, we provide an overview of the current applications of polymeric nanoparticles as platforms in the development of novel nanomedicines for cancer treatment. In particular, we will focus on the raw materials that are widely used for polymeric nanoparticle generation, current methods for formulation, mechanism of action, and clinical investigations.

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Section: From Raw Materials To Polymeric Npsmentioning

confidence: 99%

Polyester Polymeric Nanoparticles as Platforms in the Development of Novel Nanomedicines for Cancer Treatment

Niza

Ocaña

Castro‐Osma

et al. 2021

Cancers

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“…For the treatment of colon cancer, 49 was encapsulated in hybrid DOTA-PLGA nanoparticles decorated with hyaluronic acid (HA). 178 HA was used because it has many favorable properties, including recognition of its receptor CD44, which is overexpressed in tumor-cell membranes. 179 In vitro and in vivo studies were performed and showed higher therapeutic efficacy of the 49 -loaded DOTA-PLGA nanoparticles than free 49 .…”

Section: Synthetic Allyl Compounds and Their Importance In Cancer The...mentioning

confidence: 99%

“…HA recognizes the CD44 receptor that is overexpressed on tumor cell membranes. 178 These are examples of how nanomedicine can be used, in these cases for targeted therapy, to get the drug to its target and prevent it from interacting in undesired areas, in order to reduce its toxicity. The microenvironment of tumor cells is very different from that of healthy cells, and these differences can be used to develop targeted therapies.…”

Section: Synthetic Allyl Compounds and Their Importance In Cancer The...mentioning

confidence: 99%

From Natural Sources to Synthetic Derivatives: The Allyl Motif as a Powerful Tool for Fragment-Based Design in Cancer Treatment

et al. 2023

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Since the beginning of history, natural products have been an abundant source of bioactive molecules for the treatment of different diseases, including cancer. Many allyl derivatives, which have shown anticancer activity both in vitro and in vivo in a large number of cancers, are bioactive molecules found in garlic, cinnamon, nutmeg, or mustard. In addition, synthetic products containing allyl fragments have been developed showing potent anticancer properties. Of particular note is the allyl derivative 17-AAG, which has been evaluated in Phase I and Phase II/III clinical trials for the treatment of multiple myeloma, metastatic melanoma, renal cancer, and breast cancer. In this Perspective, we compile extensive literature evidence with descriptions and discussions of the most recent advances in different natural and synthetic allyl derivatives that could generate cancer drug candidates in the near future.

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“…HA-NPs-17AAG induced apoptosis more than free 17AAG in cancer cells. Additionally, HA-NPs-17AAG significantly inhibited tumor growth than free 17AAG in mice [12]. Poly (3-hydroxybutyrate-co-3-hydroxyvalerate acid) (PHBV)/PLGA NPs were developed for co-delivery of 5FU and oxaliplatin for colon cancer treatment.…”

Section: Nanocarries For Colon Cancer Drug Deliverymentioning

confidence: 99%

“…A number of nanocarriers have been employed as drug delivery systems for improving cancer treatment including dendrimer [7], chitosan [8], liposome [4], polymeric NPs [9], micelle [10] and exosomes [11]. Decorated nanocarriers with targeted ligands can identify receptors on cell surface which lead to enhance cellular uptake, reduce adverse effects and provide effective release of drugs [12,13].…”

Section: Introductionmentioning

confidence: 99%

Targeted Nano-Drug Delivery System to Colon Cancer

Moghimipour¹,

Handali²

2022

Smart Drug Delivery

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Cancer has been considered as the most cause of death in world. Employing of nanocarriers as drug delivery systems provide a platform for delivering drugs with increasing the anti-cancer efficacy, enhancing bioavailability of drugs, reducing side effects, enhancing the circulation half-life of drugs, improving the distribution of drugs and overcoming drug resistance. A number of nanocarriers have been studied as drug delivery systems for improving the treatment of cancer including liposomes, micelle, polymeric nanoparticles, carbon nanotubes, dendrimers, solid lipid nanoparticle (SLN) and nanostructure lipid carrier (NLC). In order to enhance recognition and internalization of nanocarriers by the target tissues, their surfaces can be modified with targeting ligands such as integrins, transferrin, folic acid, polysaccharides and antibodies. In this chapter, we are going to introduce the targeted nanocarriers for improving the cytotoxic action of drugs with further attempt of decreasing dose to achieve higher anticancer activity. Targeted nanocarriers would provide a promising therapeutic approach for cancer.

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Hybrid Nanoparticles Modified by Hyaluronic Acid Loading an HSP90 Inhibitor as a Novel Delivery System for Subcutaneous and Orthotopic Colon Cancer Therapy

Cited by 11 publications

References 37 publications

Polyester Polymeric Nanoparticles as Platforms in the Development of Novel Nanomedicines for Cancer Treatment

Polyester Polymeric Nanoparticles as Platforms in the Development of Novel Nanomedicines for Cancer Treatment

From Natural Sources to Synthetic Derivatives: The Allyl Motif as a Powerful Tool for Fragment-Based Design in Cancer Treatment

Targeted Nano-Drug Delivery System to Colon Cancer

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