Wireless and battery-free technologies for neuroengineering

Won, Sang Min; Cai, Le; Gutruf, Philipp; Rogers, John A.

doi:10.1038/s41551-021-00683-3

Cited by 206 publications

(202 citation statements)

References 245 publications

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“…On top of that, as the targeted area of study is deep in the brain, this will result in larger tethers that are harder to manage. Thus, the option of a wireless-based system has raised the interests of many researchers in the area (see [39] for a review).…”

Section: Neural Interface Technologymentioning

confidence: 99%

“…Wireless devices also need to interface with neurons whilst having the capability of converting wireless energy into circuit current (batteryless). This added complexity is nowadays feasible with energy-converting mechanisms based on microelectronics and nanotechnology [39]. Additionally, wireless implants require consideration of the human body as a communication channel.…”

Section: Neural Interface Technologymentioning

confidence: 99%

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Neurosciences and Wireless Networks: The Potential of Brain-Type Communications and Their Applications

Moioli

Nardelli

Barros

et al. 2021

IEEE Commun. Surv. Tutorials

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This paper presents the first comprehensive tutorial on a promising research field located at the frontier of two wellestablished domains, neurosciences and wireless communications, motivated by the ongoing efforts to define the Sixth Generation of Mobile Networks (6G). In particular, this tutorial first provides a novel integrative approach that bridges the gap between these two seemingly disparate fields. Then, we present the state-ofthe-art and key challenges of these two topics. In particular, we propose a novel systematization that divides the contributions into two groups, one focused on what neurosciences will offer to future wireless technologies in terms of new applications and systems architecture (Neurosciences for Wireless Networks), and the other on how wireless communication theory and nextgeneration wireless systems can provide new ways to study the brain (Wireless Networks for Neurosciences). For the first group, we explain concretely how current scientific understanding of the brain would enable new applications within the context of a new type of service that we dub brain-type communications and that has more stringent requirements than human-and machine-type communication. In this regard, we expose the key requirements of brain-type communication services and discuss how future wireless networks can be equipped to deal with such services. Meanwhile, for the second group, we thoroughly explore modern communication systems paradigms, including Internet of Bio-Nano Things and wireless-integrated brainmachine interfaces, in addition to highlighting how complex systems tools can help bridging the upcoming advances of wireless technologies and applications of neurosciences. Brain-controlled vehicles are then presented as our case study to demonstrate for both groups the potential created by the convergence of neurosciences and wireless communications, probably in 6G. In summary, this tutorial is expected to provide a largely missing articulation between neurosciences and wireless communications while delineating concrete ways to move forward in such an interdisciplinary endeavor.

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Section: Neural Interface Technologymentioning

confidence: 99%

Section: Neural Interface Technologymentioning

confidence: 99%

Neurosciences and Wireless Networks: The Potential of Brain-Type Communications and Their Applications

Moioli

Nardelli

Barros

et al. 2021

IEEE Commun. Surv. Tutorials

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show abstract

“…The commonly used approach is to start with structural design, such as using an “island‐bridge” structure using serpentine interconnected electrical components, [ 159 ] mesh structures, or multilayer stacked structures integrated on a soft substrate such as PDMS elastomer. [ 165,166 ] Weight and volume are typically reduced by hundreds of times, compared to conventional rigid antennas. Figure a shows a miniaturized, battery‐free, wireless optofluidic system for wireless drug delivery and optogenetic stimulation.…”

Section: External Wpt Technologymentioning

confidence: 99%

“…Therefore, such waves have much shorter wavelengths at similar frequencies, such as 0.3–0.7 mm for medical imaging. [ 166 ] Ultrasound‐induced wireless energy harvesting (UWEH) is an emerging technology whose main feature is to convert ultrasound waves emitted to electrical power through piezoelectric‐semiconducting coupling. According to the energy conversion mechanisms, the ultrasonic energy harvesters can be distinguished into two categories: piezoelectric and capacitive UWEH system.…”

Section: External Wpt Technologymentioning

confidence: 99%

Recent Advances of Energy Solutions for Implantable Bioelectronics

Sheng

Zhang

Liang

et al. 2021

Adv Healthcare Materials

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The emerging field of implantable bioelectronics has attracted widespread attention in modern society because it can improve treatment outcomes, reduce healthcare costs, and lead to an improvement in the quality of life. However, their continuous operation is often limited by conventional bulky and rigid batteries with a limited lifespan, which must be surgically removed after completing their missions and/or replaced after being exhausted. Herein, this paper gives a comprehensive review of recent advances in nonconventional energy solutions for implantable bioelectronics, emphasizing the miniaturized, flexible, biocompatible, and biodegradable power devices. According to their source of energy, the promising alternative energy solutions are sorted into three main categories, including energy storage devices (batteries and supercapacitors), internal energy‐harvesting devices (including biofuel cells, piezoelectric/triboelectric energy harvesters, thermoelectric and biopotential power generators), and external wireless power transmission technologies (including inductive coupling/radiofrequency, ultrasound‐induced, and photovoltaic devices). Their fundamentals, materials strategies, structural design, output performances, animal experiments, and typical biomedical applications are also discussed. It is expected to offer complementary power sources to extend the battery lifetime of bioelectronics while acting as an independent power supply. Thereafter, the existing challenges and perspectives associated with these powering devices are also outlined, with a focus on implantable bioelectronics.

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“…Battery‐free, wirelessly powered electronic devices have been developed for advanced therapeutics, [ 1 ] healthcare, [ 2 ] and neuroengineering. [ 3 ] For the long‐term use of those devices interfaced with living animal/human body, it is hence essential to resolve the mechanical mismatch between soft target tissues and rigid parts of the device (e.g., antennas, interconnects, and surface‐mounted components). [ 4,5 ] To this end, the development of flexible and stretchable antennas is of great importance to enhance the mechanical conformability of wireless devices.…”

Section: Introductionmentioning

confidence: 99%

Ultra‐Deformable and Tissue‐Adhesive Liquid Metal Antennas with High Wireless Powering Efficiency

et al. 2021

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Flexible and stretchable antennas are important for wireless communication using wearable and implantable devices to address mechanical mismatch at the tissue–device interface. Emerging technologies of liquid‐metal‐based stretchable electronics are promising approaches to improve the flexibility and stretchability of conventional metal‐based antennas. However, existing methods to encapsulate liquid metals require monolithically thick (at least 100 µm) substrates, and the resulting devices are limited in deformability and tissue‐adhesiveness. To overcome this limitation, fabrication of microchannels by direct ink writing on a 7 µm‐thick elastomeric substrate is demonstrated, to obtain liquid metal microfluidic antennas with unprecedented deformability. The fabricated wireless light‐emitting device is powered by a standard near‐field‐communication system (13.56 MHz, 1 W) and retained a consistent operation under deformations including stretching (>200% uniaxial strain), twisting (180° twist), and bending (3.0 mm radius of curvature) while maintaining a high quality factor (q > 20). Suture‐free conformal adhesion of the polydopamine‐coated device to ex vivo animal tissues under mechanical deformations is also demonstrated. This technology offers a new capability for the design and fabrication of wireless biomedical devices requiring conformable tissue‐device integration toward minimally invasive, imperceptible medical treatments.

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Wireless and battery-free technologies for neuroengineering

Cited by 206 publications

References 245 publications

Neurosciences and Wireless Networks: The Potential of Brain-Type Communications and Their Applications

Neurosciences and Wireless Networks: The Potential of Brain-Type Communications and Their Applications

Recent Advances of Energy Solutions for Implantable Bioelectronics

Ultra‐Deformable and Tissue‐Adhesive Liquid Metal Antennas with High Wireless Powering Efficiency

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