Dihydromyricetin attenuates heat stress-induced apoptosis in dairy cow mammary epithelial cells through suppressing mitochondrial dysfunction

Wang, Huili; Xing, Guolan; Qian, Yong; Sun, Xiaojuan; Zhong, Jun; Chen, Kun-Lin

doi:10.1016/j.ecoenv.2021.112078

Cited by 27 publications

(12 citation statements)

References 54 publications

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“…Various phytochemicals such as resveratrol, 14 epigallocatechin gallate, 15 and dihydromyricetin 16 showed promising effects in mitigating HS. However, this was achieved by the anti-oxidation activity.…”

Section: Introductionmentioning

confidence: 99%

l-Theanine attenuates heat stress-induced proteotoxicity and alterations in carbohydrate and lipid metabolism via heat shock factor 1

et al. 2023

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Section: Introductionmentioning

confidence: 99%

l-Theanine attenuates heat stress-induced proteotoxicity and alterations in carbohydrate and lipid metabolism via heat shock factor 1

et al. 2023

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“…Asides from the major effects described above, DMY appears promising for the treatment of inflammatory diseases, such as asthma [109], osteoarthritis [45], rheumatoid arthritis [113], acute pancreatitis [114], and mastitis [115]. Other disorders in which DMY appeared functional included human melanoma [116] and hypertrophic scar [117].…”

Section: Pharmacological Effects and Actions Mechanisms Of Dmymentioning

confidence: 99%

“…acute pancreatitis [114], and mastitis [115]. Other disorders in which DMY appeared functional included human melanoma [116] and hypertrophic scar [117].…”

Section: Miscellaneousmentioning

confidence: 99%

A multifaceted review on dihydromyricetin resources, extraction, bioavailability, biotransformation, bioactivities, and food applications with future perspectives to maximize its value

Zhang

Caprioli²,

Hussain

et al. 2021

eFood

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Natural bioactive compounds present a better alternative to prevent and treat chronic diseases owing to their lower toxicity and abundant resources. (+)-Dihydromyricetin (DMY) is a flavanonol, possessing numerous interesting bioactivities with abundant resources. This review provides a comprehensive overview of the recent advances in DMY natural resources, stereoisomerism, physicochemical properties, extraction, biosynthesis, pharmacokinetics, and biotransformation. Stereoisomerism of DMY should be considered for better indication of its efficacy. Biotechnological approach presents a potential tool for the production of DMY using microbial cell factories. DMY high instability is related to its powerful antioxidant capacity due to pyrogallol moiety in ring B, and whether preparation of other analogues could demonstrate improved properties. DMY demonstrates poor bioavailability based on its low solubility and permeability with several attempts to improve its pharmacokinetics and efficacy. DMY possesses various pharmacological effects, which have been proven by many in vitro and in vivo experiments, while clinical trials are rather scarce, with underlying action mechanisms remaining unclear. Consequently, to maximize the usefulness of DMY in nutraceuticals, improvement in bioavailability, and better understanding of its actions mechanisms and drug interactions ought to be examined in the future along with more clinical evidence.

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“…Oxidative stress is a condition of damage resulting from an imbalance between free radical production and antioxidant defense (Lobo et al, 2010). Many external injuries by trauma, infection, heat, and so forth, may lead to short‐term oxidative stress, which produces increased radical generation causing a wide range of damage to molecular species including lipids, proteins, and nucleic acids (Abdelmegeed & Mukhopadhyay, 2019; H. L. Wang et al, 2021). Besides, oxidative stress is now considered a significant contributor to neurological disorders (Song et al, 2019), inflammatory diseases (Li & Chang, 2021), aging (Schmidlin et al, 2019), and so forth.…”

Section: Introductionmentioning

confidence: 99%

The study of single‐cell dynamics contributes to the evaluation of food‐derived antioxidant capacity

Xiang

Qing

et al. 2023

eFood

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Exploring potential food‐derived bioactive substances that relieve oxidative stress is considered an important goal for antioxidant research. We first used the long‐pair electron index and orbital fingerprint to predict the molecular interactions in a range of polyphenols and polypeptides. We found Rutin and peptide PW5 had the highest LPE index values. Subsequently, by D‐galactose (D‐gal)‐induced oxidative NIH3T3 cell model, we proved both Rutin and PW5 could effectively protect cells against D‐gal‐induced damage, through enhancement in cell proliferation and reduction in β‐galactosidase activity. Although Rutin displayed better performance than PW5 in the oxidative stress model, we confirmed Rutin stimulated obvious changes in the morphology and motility of normal NIH3T3 cells based on the real‐time dynamic images. Taken together, combined computational and typical model experiment methods, proved useful in efficiently screening food‐derived antioxidants. Moreover, the analytical results of cell morphology and movement may provide novel insights for the safety evaluation of antioxidants.

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Dihydromyricetin attenuates heat stress-induced apoptosis in dairy cow mammary epithelial cells through suppressing mitochondrial dysfunction

Cited by 27 publications

References 54 publications

l-Theanine attenuates heat stress-induced proteotoxicity and alterations in carbohydrate and lipid metabolism via heat shock factor 1

l-Theanine attenuates heat stress-induced proteotoxicity and alterations in carbohydrate and lipid metabolism via heat shock factor 1

A multifaceted review on dihydromyricetin resources, extraction, bioavailability, biotransformation, bioactivities, and food applications with future perspectives to maximize its value

The study of single‐cell dynamics contributes to the evaluation of food‐derived antioxidant capacity

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