Ambient air pollutant exposure and in vitro fertilization treatment outcomes in Zhengzhou, China

Dai, Wei; Shi, Hao; Bu, Zhiqin; Yu, Yiping; Sun, Zheng; Hu, Linli; Sun, Yingpu

doi:10.1016/j.ecoenv.2021.112060

Cited by 13 publications

(5 citation statements)

References 27 publications

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“…Similar to a previous study in IVF patients ( 18 ), the clinical pregnancy rate in our study was 61.2%. A study performed in Shengyang, China showed that the intrauterine pregnancy rate was 46.0% ( 27 ), which was lower than the recorded rate in our study.…”

Section: Discussionsupporting

confidence: 91%

“…Furthermore, the timing of conception is known with certainty because key events in the IVF treatment are timed and trigger by a physician, exact exposure periods of air pollutants can be determined ( 16 , 17 ). To date, several studies have reported the association between air pollutants exposure and follicle growth, a reduced rate of implantation, pregnancy or live birth in women who underwent ART treatment, but the results were inconsistent ( 16 , 18 – 21 ). However, few epidemiology studies have explored the effects of ambient air pollution during different time windows on PTB incidence in patients who underwent IVF treatment in China.…”

Section: Introductionmentioning

confidence: 99%

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Association Between Ambient Air Pollutants Exposure and Preterm Birth in Women Who Underwent in vitro Fertilization: A Retrospective Cohort Study From Hangzhou, China

et al. 2021

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Objectives: Exposure to air pollutants has been linked to preterm birth (PTB) after natural conception. However, few studies have explored the effects of air pollution on PTB in patients who underwent in vitro fertilization (IVF). We aimed to investigate the association between ambient air pollutants exposure and PTB risk in IVF patients.Methods: This retrospective cohort study included 2,195 infertile women who underwent IVF treatment from January 2017 and September 2020 in Hangzhou Women's Hospital. Totally 1,005 subjects who underwent a first fresh embryo(s) transfer cycle were analyzed in this study. Residential exposure to ambient six air pollutants (PM2.5, PM10, SO2, NO2, CO, O3) during various periods of the IVF timeline were estimated by satellite remote-sensing and ground measurement. Cox proportional hazards models for discrete time were used to explore the association between pollutants exposure and incident PTB, with adjustment for confounders. Stratified analyses were employed to explore the effect modifiers.Results: The clinical pregnancy and PTB rates were 61.2 and 9.3%, respectively. We found that PM2.5 exposure was significantly associated with an increased risk of PTB during 85 days before oocyte retrieval [period A, adjusted hazard ratio, HR=1.09, 95%CI: 1.02–1.21], gonadotropin start to oocyte retrieval [period B, 1.07 (1.01–1.19)], first trimester of pregnancy [period F, 1.06 (1.01–1.14)], and the entire IVF pregnancy [period I, 1.07 (1.01–1.14)], respectively. An interquartile range increment in PM10 during periods A and B was significantly associated with PTB at 1.15 (1.04–1.36), 1.12 (1.03–1.28), and 1.14 (1.01–1.32) for NO2 during period A. The stratified analysis showed that the associations were stronger for women aged <35 years and those who underwent two embryos transferred.Conclusions: Our study suggests ambient PM2.5, PM10, and NO2 exposure were significantly associated with elevated PTB risk in IVF patients, especially at early stages of IVF cycle and during pregnancy.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Association Between Ambient Air Pollutants Exposure and Preterm Birth in Women Who Underwent in vitro Fertilization: A Retrospective Cohort Study From Hangzhou, China

et al. 2021

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“…Ecologic studies in the U.S. ( Xue and Zhu, 2018b ), Spain ( Nieuwenhuijsen et al, 2014 ), and China ( Xue and Zhu, 2018a ) have found that counties or census tracts with higher levels of air pollution have lower fertility rates. Associations between air pollution and markers of fertility have also been reported in studies of couples undergoing in vitro fertilization (IVF) ( Boulet et al, 2019 ; Choe et al, 2018 ; Dai et al, 2021 ; Gaskins et al, 2018 , 2019 ; Iodice et al, 2021 ; Jin et al, 2022 ; Legro et al, 2010 ; Li et al, 2020 ; Liu et al, 2022 , 2023 ; Qiu et al, 2019 ; Shi et al, 2021 ; Tartaglia et al, 2022 ; Wu et al, 2021 , 2023 ; Zeng et al, 2020 ; Zhang et al, 2022 ; Quraishi et al, 2019 ) and among couples trying to conceive spontaneously ( Li et al, 2021 ; Mahalingaiah et al, 2016 ; Mendola et al, 2017 ; Nobles et al, 2018 ; Slama et al, 2013 ; Wesselink et al, 2020 , 2022 ). However, the pollutants associated with reduced fertility and the window of exposure during which an association was observed were not consistent across studies.…”

Section: Introductionmentioning

confidence: 77%

Air pollution and fecundability in a North American preconception cohort study

Wesselink,

Hystad,

Kirwa

et al. 2023

Environment International

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“…These results are consistent with the results of some previous studies. A retrospective study reported the exposure to PM 2.5 or PM 10 before the period of oocyte retrieval adversely affected pregnancy and live birth rates in the general population undergoing IVF ( 27 ). Another study from Shanghai by Shi found a higher exposure to PM 10 , NO 2 , and SO 2 was related to reduced pregnancy or live birth rates in general patients with IVF ( 28 ).…”

Section: Discussionmentioning

confidence: 99%

Air pollution exposure and pregnancy outcomes among women with polycystic ovary syndrome

Zhu

Cai

Guo

et al. 2022

Front. Public Health

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BackgroundRecently, the relationship between air pollution and reproductive outcomes has become a research focus. However, there is a lack of research on the relationship between air pollution and polycystic ovary syndrome (PCOS).MethodsThis is a retrospective cohort study included a total of 1,652 women with PCOS and 12,543 women without PCOS conducted from 1 January 2015 to 31 December 2019. The average daily concentration data of six air pollutants (PM2.5, PM10, O3, NO2, SO2, and CO) during different exposure windows were obtained. Generalized estimating equation models were used to evaluate the association of air pollution with pregnancy outcomes.ResultsAir pollutants were not found to have a significant association with pregnancy rates among patients with PCOS. However, each IQR increase in PM10 exposure during period 3 (embryo transfer to serum HCG test) was associated with the reduced clinical pregnancy rate (adjusted OR = 0.92, 95% CI: 0.84–0.99) for patients without PCOS. Patients without PCOS showed lower clinical pregnancy rates with increased exposure to NO2 during periods 2 (oocyte retrieval to embryo transfer) and 5 (start of gonadotropin medication to embryo transfer), with aORs and 95% CIs of 0.94 (0.88, 0.99) and 0.94 (0.88, 0.98), respectively. Each IQR increase in SO2 among patients without PCOS during periods 1 (start of gonadotropin medication to oocyte retrieval), 2, 5, and 6 (start of gonadotropin medication to serum HCG test) was related to a decrease in clinical pregnancy rate. For the live birth rate, no significant relationship was found between air pollutants, including PM2.5, PM10, SO2, NO2, CO, and O3, and the live birth rate for women with PCOS. However, women without PCOS presented a lower probability of live birth with exposure to SO2 during periods 1, 2, 5, and 6.ConclusionThis retrospective study of reproductive-aged women observed no significant relationships between ambient pollutants and pregnancy outcomes among women with PCOS but found negative associations among women without PCOS.

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Ambient air pollutant exposure and in vitro fertilization treatment outcomes in Zhengzhou, China

Cited by 13 publications

References 27 publications

Association Between Ambient Air Pollutants Exposure and Preterm Birth in Women Who Underwent in vitro Fertilization: A Retrospective Cohort Study From Hangzhou, China

Association Between Ambient Air Pollutants Exposure and Preterm Birth in Women Who Underwent in vitro Fertilization: A Retrospective Cohort Study From Hangzhou, China

Air pollution and fecundability in a North American preconception cohort study

Air pollution exposure and pregnancy outcomes among women with polycystic ovary syndrome

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