The Association Between Antibody Response to Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Post–COVID-19 Syndrome in Healthcare Workers

Abstract

It is currently unknown how Post-COVID-19 Syndrome (PCS) may affect those infected with SARS-CoV-2. This longitudinal study reports on healthcare staff who tested positive for SARS-CoV-2 between March-April 2020 and follows their antibody titres and symptomatology. Over half (n=21/38) had PCS at 7-8 months. There was no statistically significant difference between initial RT-PCR viral titres or serial antibody levels between those who did and did not develop PCS. This study highlights the relative commonality of PCS in healthcare workers and this should be considered in vaccination scheduling and workforce planning to allow adequate frontline staffing numbers.

Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis

“…Bashlyaeva Children’s Municipal Clinical Hospital N= 518 children (all previously hospitalized cases) Age Range: ≤18 Median Age: 10.4 (3–15.2) Sex (%F/%M): 52.1/47.9 Median 256 (223-271) days following discharge RT-PCR Subjective self-report via telephone surveyconducted by medical students 10.7% (53/518) reported fatigue scores on wellness scale for children with 2+ persistent symptoms significantly declined when compared to before COVID-19 onset (from 90 ( Augustin et al, 2021 , Cirulli et al, 2020 , Darley et al, 2021 , Ferrucci et al, 2021 , Kashif et al, 2021 , O’Keefe et al, 2021 , Peghin et al, 2021 , Shang et al, 2021 , Simani et al, 2021 , Stavem et al, 2021 , Xiong et al, 2021 , González-Hermosillo et al, 2021 , Petersen et al, 20212021 , Tawfik et al, 2021;18(3):em291. , Mei et al, 2021 , Evlice et al, 2021 ) to 70 ( Jacobson et al, 2021 , Johnsen et al, 2021 , Latronico et al, 2020 , Logue et al, 2021 , Menges et al, 2021 , Miskowiak et al, 2021 , Munblit et al, 2021 , Orrù et al, 2021 , Osmanov et al, 2021 , Pereira et al, 20212021 , Qu et al, 2021 , Rass et al, 2021;(ene.14803). , Savarraj et al, 2020 , Soldati et al, 2021 , Soraas et al, 2021 , Walle-Hansen et al, 2021 , Taboada et al, 2021 , Van Veenendaal et al, 2021 , Szende et al, 2014 , …”

“…Participants reported lower scores (poorer health state) at follow up (median 80 ( Miskowiak et al, 2021 , Munblit et al, 2021 , Orrù et al, 2021 , Osmanov et al, 2021 , Pereira et al, 20212021 , Qu et al, 2021 , Rass et al, 2021;(ene.14803). , Savarraj et al, 2020 , Soldati et al, 2021 , Soraas et al, 2021 , Walle-Hansen et al, 2021 , Taboada et al, 2021 , Van Veenendaal et al, 2021 , Szende et al, 2014 , Amin-Chowdhury et al, 2021 , Augustin et al, 2021 , Cirulli et al, 2020 , Darley et al, 2021 , Ferrucci et al, 2021 , Kashif et al, 2021 , O’Keefe et al, 2021 , Peghin et al, 2021 , Shang et al, 2021 , Simani et al, 2021 , Stavem et al, 2021 , Xiong et al, 2021 ) compared to pre-COVID (median 85 ( Qu et al, 2021 , Rass et al, 2021;(ene.14803).…”

Post–COVID-19 syndrome and humoral response association after 1 year in vaccinated and unvaccinated patients

“…Knowledge concerning humoral immune response to SARS-CoV-2 and its relationship with post-COVID-19 syndrome is still incomplete ( 5 , 6 , 25 , 26 , 27 ). We found a significant association between growing titres of non-RBD SARS-CoV-2 antibodies after natural infection and post-COVID-19 syndrome in the prolonged follow-up.…”

“…The potential pathophysiological mechanisms are unknown and may encompass a complex interaction between the virus-specific cytopathic effects, the inflammatory damage, the allo- and autoimmune responses to the acute infection on the one hand, and the expected sequelae of post-critical illness due to organ and microvascular damage on the other ( 4 ). To date, there is still a gap on how natural immunity and hybrid immunity, which refer to the immune-strengthening effect of exposure to infection followed by vaccination, function in post-COVID 19 ( 5 , 6 , 7 ). A few studies available have suggested both a potential improvement and deterioration of post-COVID-19 symptoms after vaccination in previously infected patients and variable associations between humoral responses and post-COVID-19 syndrome after the natural infection ( 8 , 9 , 10 , 11 ).…”

SARS-CoV-2 Antibodies in the Public Hospital Staff: The Second Report of a Seroprevalence Cohort Study from Iran

“…In addition, in health care workers with the post-covide syndrome (PCS), one study found no significant relationship between RT-PCR and antibody level. The results showed that although some health care workers developed a severe and prolonged infection, the antibodies were not produced after infection (29). Thus, the frontline HCWs are at a higher risk of severe disease and mortality.…”