Lipid, fatty acid, carnitine- and choline derivative profiles in rheumatoid arthritis outpatients with different degrees of periodontal inflammation

Beyer, Kathrin; Lie, Stein Atle; Bjørndal, Bodil; Berge, Rolf K.; Svardal, Asbjørn; Brun, Johan G.; Bolstad, Anne Isine

doi:10.1038/s41598-021-84122-y

Cited by 11 publications

(8 citation statements)

References 78 publications

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“…This suggested that acylcarnitine might play an important role in the link between OA and metabolic diseases or cardiovascular diseases, and the potential mechanism is likely related to the β-oxidation of fatty acid metabolism in mitochondria. In addition, studies have shown that acylcarnitine metabolism was significantly related to the progression of another arthritis disease, rheumatoid arthritis (RA) [ 28 , 29 ]. In the study conducted by Beyer et al on the serum of 78 RA patients, they found that the changes in mitochondrial function related to the inflammatory state in RA disease may be related to the metabolism of acylcarnitine [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, studies have shown that acylcarnitine metabolism was significantly related to the progression of another arthritis disease, rheumatoid arthritis (RA) [ 28 , 29 ]. In the study conducted by Beyer et al on the serum of 78 RA patients, they found that the changes in mitochondrial function related to the inflammatory state in RA disease may be related to the metabolism of acylcarnitine [ 28 ]. Andonian et al showed in the study of 48 RA patients that the abnormal metabolism of long-chain acylcarnitine may be an internal link between RA inflammation and cardiometabolic comorbidities [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

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Serum Metabolomic Signatures for Knee Cartilage Volume Loss over 10 Years in Community-Dwelling Older Adults

Xie

Aitken

Liu

et al. 2022

Life

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Osteoarthritis (OA) is the most prevalent joint disorder characterized by joint structural pathological changes with the loss of articular cartilage as its hallmark. Tools that can predict cartilage loss would help identify people at high risk, thus preventing OA development. The recent advance of the metabolomics provides a new avenue to systematically investigate metabolic alterations in disease and identify biomarkers for early diagnosis. Using a metabolomics approach, the current study aimed to identify serum metabolomic signatures for predicting knee cartilage volume loss over 10 years in the Tasmania Older Adult Cohort (TASOAC). Cartilage volume was measured in the medial, lateral, and patellar compartments of the knee by MRI at baseline and follow-up. Changes in cartilage volume over 10 years were calculated as percentage change per year. Fasting serum samples collected at 2.6-year follow-up were metabolomically profiled using the TMIC Prime Metabolomics Profiling Assay and pairwise metabolite ratios as the proxies of enzymatic reaction were calculated. Linear regression was used to identify metabolite ratio(s) associated with change in cartilage volume in each of the knee compartments with adjustment for age, sex, and BMI. The significance level was defined at α = 3.0 × 10−6 to control multiple testing. A total of 344 participants (51% females) were included in the study. The mean age was 62.83 ± 6.13 years and the mean BMI was 27.48 ± 4.41 kg/m2 at baseline. The average follow-up time was 10.84 ± 0.66 years. Cartilage volume was reduced by 1.34 ± 0.72%, 1.06 ± 0.58%, and 0.98 ± 0.46% per year in the medial, lateral, and patellar compartments, respectively. Our data showed that the increased ratios of hexadecenoylcarnitine (C16:1) to tetradecanoylcarnitine (C14) and C16:1 to dodecanoylcarnitine (C12) were associated with 0.12 ± 0.02% reduction per year in patellar cartilage volume (both p < 3.03 × 10−6). In conclusion, our data suggested that alteration of long chain fatty acid β-oxidation was involved in patellar cartilage loss. While confirmation is needed, the ratios of C16:1 to C14 and C12 might be used to predict long-term cartilage loss.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Serum Metabolomic Signatures for Knee Cartilage Volume Loss over 10 Years in Community-Dwelling Older Adults

Xie

Aitken

Liu

et al. 2022

Life

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“…In a study by Beyer et al [ 60 ], the total concentration of FAs was higher in patients with active RA than in those in remission ( p = 0.047). Similarly, RA patients treated with prednisolone had a higher total concentration of FAs as compared to those who did not receive prednisolone ( p = 0.043).…”

Section: The Role Of Fatty Acids In the Treatment Of Ramentioning

confidence: 98%

The Relationship between Fatty Acids and the Development, Course and Treatment of Rheumatoid Arthritis

Tański¹,

Świątoniowska-Lonc²,

Tabin³

et al. 2022

Nutrients

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For this systematic review, a search of the relevant literature was conducted in the EMBASE and PubMed databases. We used the following terms: ‘rheumatoid arthritis’ in conjunction with ‘fatty acid’. The following inclusion criteria had to be satisfied for the studies to be included in the analysis: an RCT/observational/cohort study published in English. A total of seventy-one studies were analysed. The presented systematic review of the available data indicates that increased consumption of omega-3 fatty acids (FAs) may have a beneficial effect on human health by decreasing pain and disease activity in patients with RA. The beneficial effect of unsaturated FA on the clinical parameters of RA was demonstrated in all 71 studies analysed. The content of omega-3 FAs in the diet and the consumption of fish, which are their main source, may contribute to a reduced incidence of RA. FAs are an essential component in the synthesis of eicosanoids that exhibit anti-inflammatory properties. Due to the documented positive influence of unsaturated FAs on treatment outcomes, the use of a diet rich in long-chain unsaturated FAs should be the standard of care, along with pharmacotherapy, in the treatment of RA patients. An important element in the control of the treatment process should be the routine assessment of the quality of life of RA patients.

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“…The relationships between RA and periodontitis include similarities in genetic risk factors and immunopathogenesis, pathological mechanisms of chronic inflammation and bone destruction as well as increased production of cytokines, prostaglandins and matrix‐degrading enzymes (Beyer et al, 2021; Bolstad et al, 2020; Janssen et al, 2013; Rutger Persson, 2012; Stabholz et al, 2010). Among the shared risk factors, cigarette smoking is the most prominent (Klareskog et al, 2006; Papapanou et al, 2018; Razali et al, 2005; Tomar & Asma, 2000).…”

Section: Introductionmentioning

confidence: 99%

Increased risk of periodontitis in patients with rheumatoid arthritis: A nationwide register study in Norway

Bolstad

Fevang

Lie

2023

J Clinic Periodontology

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Aim To investigate the risk of periodontitis in rheumatoid arthritis (RA) patients in a nationwide register‐based study. Materials and Methods Patients and controls were defined using ICD‐10 codes registered in the Norwegian Patient Registry (NPR), from 2011 to 2017. The 324,232 included subjects had at least one registered diagnostic code for RA (33,040 patients) or diagnostic codes for non‐osteoporotic fractures or hip or knee replacement due to osteoarthritis (controls). The outcome was periodontitis, defined by codes for periodontal treatment from the Norwegian Control and Payment of Health Reimbursements Database (KUHR). Hazard ratios (HRs) were calculated for periodontitis in RA patients compared to controls. Generalized additive model in Cox regressions was estimated to visualize periodontitis occurrences as a function of number of RA visits. Results The risk of periodontitis increased with increasing number of RA visits. RA patients having 10 or more visits during the 7‐year period had a 50% increased risk of periodontitis compared to controls (HR = 1.48, 95% confidence interval [CI]: 1.39–1.59); also, in patients with assumed new RA, an even higher risk estimate was seen (HR = 1.82, 95% CI: 1.53–2.17). Conclusions In this register‐based study in which periodontal treatment was used as a surrogate marker for periodontitis, we found an increased risk of periodontitis in RA patients, particularly those with active disease and new RA.

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Lipid, fatty acid, carnitine- and choline derivative profiles in rheumatoid arthritis outpatients with different degrees of periodontal inflammation

Cited by 11 publications

References 78 publications

Serum Metabolomic Signatures for Knee Cartilage Volume Loss over 10 Years in Community-Dwelling Older Adults

Serum Metabolomic Signatures for Knee Cartilage Volume Loss over 10 Years in Community-Dwelling Older Adults

The Relationship between Fatty Acids and the Development, Course and Treatment of Rheumatoid Arthritis

Increased risk of periodontitis in patients with rheumatoid arthritis: A nationwide register study in Norway

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