Marine Exopolysaccharide Complexed With Scandium Aimed as Theranostic Agents

Mazza, Mattia; Alliot, Cyrille; Sinquin, Corinne; Colliec-Jouault, Sylvia; Reiller, Pascal E.; Huclier‐Markai, Sandrine

doi:10.3390/molecules26041143

Cited by 6 publications

(2 citation statements)

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“…Compared with TPS, its complexation with iron ions and selenium ions had enhanced the antioxidant properties (Zhou et al, 2022a(Zhou et al, , 2022bAlmanaa et al, 2022;León et al, 2022), and its complexation with scandium was used in various tumors such as MNNG/HOS osteosarcoma, A375 melanoma, A549 Lung adenocarcinoma, U251 glioma, etc. with antiproliferative properties and as a nuclear medicine theragnostic agent (Mazza et al, 2021;Muñoz-Garcia et al, 2021). Due to the properties exhibited by chemically modified TPS, it was suitable for many industries such as pharmaceuticals and health food.…”

Section: Introductionmentioning

confidence: 99%

Preparation, characterization and antioxidant activity of polysaccharides copper from Qingzhuan dark tea

et al. 2023

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Tea polysaccharides was one of the active ingredients of Qingzhuan dark tea, which had antioxidant, anti-tumor, and immuneenhancing effects. The complexation of metal ions of tea polysaccharides was one of the current research hotspots. It can combine the advantages of tea polysaccharides and their complexed trace metal elements, and had great potential development. In this study, the trace element-copper required by the human body was used for complexation with Qingzhuan dark tea polysaccharides, and the structure was characterized by various chemical methods. The copper complexes of Qingzhuan dark tea polysaccharides were characterized by UV spectroscopy, FT-IR, thermogravimetric analysis, X-ray diffraction (XRD), SEM, AFM and X-ray photoelectron spectroscopy (XPS). The tests results show that it was successfully complexed with tea polysaccharides. Meanwhile, the Qingzhuan dark tea polysaccharides copper complex compound (termed TPS-Cu) showed higher scavenging activity of hydroxyl radical and ABTS free radical than the tea polysaccharides (termed TPS). Therefore, TPS-Cu can be used as a potentially effective and stable copper supplement and preventive agent.

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Section: Introductionmentioning

confidence: 99%

Preparation, characterization and antioxidant activity of polysaccharides copper from Qingzhuan dark tea

et al. 2023

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“…More precisely, a theranostic pair 44 Sc/ 47 Sc could be both employed for Positron Emission Tomography (PET) imaging to detect primary and secondary tumors, as well as for Targeted RadioTherapy in order to bombard tumor tissues with gamma radiations [21]. Complexation between EPS and scandium has already been assessed and quantified in a previous work [22]. The EPS derivatives selected for this study are a highly sulfated one, called DRS (M w = 27 kDa) and a lower-sulfated one, called DR (with M w = 16 kDa).…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative Properties of Scandium Exopolysaccharide Complexes on Several Cancer Cell Lines

et al. 2021

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Antimetastatic properties on both murine and human osteosarcoma cell lines (POS-1 and KHOS) have been evidenced using exopolysaccharide (EPS) derivatives, produced by Alteromonas infernus bacterium. These derivatives had no significant effect on the cell cycle neither a pro-apoptotic effect on osteosarcoma cells. Based on this observation, these EPSs could be employed as new drug delivery systems for therapeutic uses. A theranostic approach, i.e., combination of a predictive biomarker with a therapeutic agent, has been developed notably by combining with true pair of theranostic radionuclides, such as scandium 47Sc/44Sc. However, it is crucial to ensure that, once complexation is done, the biological properties of the vector remain intact, allowing the molecular tropism of the ligand to recognize its molecular target. It is important to assess if the biological properties of EPS evidenced on osteosarcoma cell lines remain when scandium is complexed to the polymers and can be extended to other cancer cell types. Scandium-EPS complexes were thus tested in vitro on human cell lines: MNNG/HOS osteosarcoma, A375 melanoma, A549 lung adenocarcinoma, U251 glioma, MDA231 breast cancer, and Caco2 colon cancer cells. An xCELLigence Real Cell Time Analysis (RTCA) technology assay was used to monitor for 160 h, the proliferation kinetics of the different cell lines. The tested complexes exhibited an anti-proliferative effect, this effect was more effective compared to EPS alone. This increase of the antiproliferative properties was explained by a change in conformation of EPS complexes due to their polyelectrolyte nature that was induced by complexation. Alterations of both growth factor-receptor signaling, and transmembrane protein interactions could be the principal cause of the antiproliferative effect. These results are very promising and reveal that EPS can be coupled to scandium for improving its biological effects and also suggesting that no major structural modification occurs on the ligand.

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