Multi-Channel RF Supervision Module for Thermal Magnetic Resonance Based Cancer Therapy

Han, Haopeng; Oberacker, Eva; Kuehne, André; Wang, Shuailin; Eigentler, Thomas Wilhelm; Grass, Eckhard; Niendorf, Thoralf

doi:10.3390/cancers13051001

Cited by 9 publications

(7 citation statements)

References 62 publications

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“…Recognizing the opportunities of adding a thermal intervention dimension to an MRI device for studying the role of temperature in biological systems and disease our high‐density RF array opens a trajectory to an integrated, multi‐purpose RF applicator. This applicator accommodates RF‐induced heating, in vivo temperature mapping using MR thermometry, anatomic and functional MRI, and the option for x‐nuclei MRI (Thermal MR) 56‐61 . Potential clinical applications extend beyond diagnostic cardiac imaging and can serve as a platform to treat cardiovascular diseases, where localized RF intervention might be used, eg, terminate defective electrical pathways.…”

Section: Discussionmentioning

confidence: 99%

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32‐Channel self‐grounded bow‐tie transceiver array for cardiac MR at 7.0T

Eigentler

Kuehne²,

Boehmert

et al. 2021

Magnetic Resonance in Med

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Purpose Design, implementation, evaluation, and application of a 32‐channel Self‐Grounded Bow‐Tie (SGBT) transceiver array for cardiac MR (CMR) at 7.0T. Methods The array consists of 32 compact SGBT building blocks. Transmission field (B1+) shimming and radiofrequency safety assessment were performed with numerical simulations and benchmarked against phantom experiments. In vivo B1+ efficiency mapping was conducted with actual flip angle imaging. The array’s applicability for accelerated high spatial resolution 2D FLASH CINE imaging of the heart was examined in a volunteer study (n = 7). Results B1+ shimming provided a uniform field distribution suitable for female and male subjects. Phantom studies demonstrated an excellent agreement between simulated and measured B1+ efficiency maps (7% mean difference). The SGBT array afforded a spatial resolution of (0.8 × 0.8 × 2.5) mm3 for 2D CINE FLASH which is by a factor of 12 superior to standardized cardiovascular MR (CMR) protocols. The density of the SGBT array supports 1D acceleration of up to R = 4 (mean signal‐to‐noise ratio (whole heart) ≥ 16.7, mean contrast‐to‐noise ratio ≥ 13.5) without impairing image quality significantly. Conclusion The compact SGBT building block facilitates a modular high‐density array that supports accelerated and high spatial resolution CMR at 7.0T. The array provides a technological basis for future clinical assessment of parallel transmission techniques.

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Section: Discussionmentioning

confidence: 99%

“…This applicator accommodates RF-induced heating, in vivo temperature mapping using MR thermometry, anatomic and functional MRI, and the option for x-nuclei MRI (Thermal MR). [56][57][58][59][60][61] Potential clinical applications extend beyond diagnostic cardiac imaging and can…”

Section: Discussionmentioning

confidence: 99%

32‐Channel self‐grounded bow‐tie transceiver array for cardiac MR at 7.0T

Eigentler

Kuehne²,

Boehmert

et al. 2021

Magnetic Resonance in Med

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“…This approach also suffers from compatibility issues and practical obstacles because each sub-device is provided by a different vendor. Thermal magnetic resonance (ThermalMR) integrates RF-induced heating in the HT range, in vivo non-invasive temperature mapping using MR thermometry (MRTh), and anatomical and functional MRI (and even physiometabolic MRI) in a single, multi-purpose RF applicator permitting supervised thermal theranostics [ 37 , 41 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 ]. ThermalMR adds a therapeutic dimension to a diagnostic imaging device and has great promise to address the urgent need for novel personalized patient care.…”

Section: Introductionmentioning

confidence: 99%

Advanced Radio Frequency Applicators for Thermal Magnetic Resonance Theranostics of Brain Tumors

Saha

Kuehne²,

Millward

et al. 2023

Cancers

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Thermal Magnetic Resonance (ThermalMR) is a theranostic concept that combines diagnostic magnetic resonance imaging (MRI) with targeted thermal therapy in the hyperthermia (HT) range using a radiofrequency (RF) applicator in an integrated system. ThermalMR adds a therapeutic dimension to a diagnostic MRI device. Focused, targeted RF heating of deep-seated brain tumors, accurate non-invasive temperature monitoring and high-resolution MRI are specific requirements of ThermalMR that can be addressed with novel concepts in RF applicator design. This work examines hybrid RF applicator arrays combining loop and self-grounded bow-tie (SGBT) dipole antennas for ThermalMR of brain tumors, at magnetic field strengths of 7.0 T, 9.4 T and 10.5 T. These high-density RF arrays improve the feasible transmission channel count, and provide additional degrees of freedom for RF shimming not afforded by using dipole antennas only, for superior thermal therapy and MRI diagnostics. These improvements are especially relevant for ThermalMR theranostics of deep-seated brain tumors because of the small surface area of the head. ThermalMR RF applicators with the hybrid loop+SGBT dipole design outperformed applicators using dipole-only and loop-only designs, with superior MRI performance and targeted RF heating. Array variants with a horse-shoe configuration covering an arc (270°) around the head avoiding the eyes performed better than designs with 360° coverage, with a 1.3 °C higher temperature rise inside the tumor while sparing healthy tissue. Our EMF and temperature simulations performed on a virtual patient with a clinically realistic intracranial tumor provide a technical foundation for implementation of advanced RF applicators tailored for ThermalMR theranostics of brain tumors.

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“…Literature indicates that the proton resonance frequency shift method, i.e., the most common MRT method, can provide 3D temperature maps with around 0.5 °C accuracy [ 22 , 23 , 24 ]. For H&N hyperthermia, several studies [ 25 , 26 , 27 ] have shown the feasibility of adopting MR compatible applicators; however, to date, none of them has been adopted in clinical practice. Recently, we presented the novel MR compatible applicator for the H&N region: the MRcollar [ 15 ] equipped with a novel dual-function applicator concept [ 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Experimental Validation of the MRcollar: An MR Compatible Applicator for Deep Heating in the Head and Neck Region

Sümser

Drizdal

Bellizzi

et al. 2021

Cancers

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Clinical effectiveness of hyperthermia treatments, in which tumor tissue is artificially heated to 40–44 °C for 60–90 min, can be hampered by a lack of accurate temperature monitoring. The need for noninvasive temperature monitoring in the head and neck region (H&N) and the potential of MR thermometry prompt us to design an MR compatible hyperthermia applicator: the MRcollar. In this work, we validate the design, numerical model, and MR performance of the MRcollar. The MRcollar antennas have low reflection coefficients (<−15 dB) and the intended low interaction between the individual antenna modules (<−32 dB). A 10 °C increase in 3 min was reached in a muscle-equivalent phantom, such that the specifications from the European Society for Hyperthermic Oncology were easily reached. The MRcollar had a minimal effect on MR image quality and a five-fold improvement in SNR was achieved using the integrated coils of the MRcollar, compared to the body coil. The feasibility of using the MRcollar in an MR environment was shown by a synchronous heating experiment. The match between the predicted SAR and measured SAR using MR thermometry satisfied the gamma criteria [distance-to-agreement = 5 mm, dose-difference = 7%]. All experiments combined show that the MRcollar delivers on the needs for MR—hyperthermia in the H&N and is ready for in vivo investigation.

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Multi-Channel RF Supervision Module for Thermal Magnetic Resonance Based Cancer Therapy

Cited by 9 publications

References 62 publications

32‐Channel self‐grounded bow‐tie transceiver array for cardiac MR at 7.0T

32‐Channel self‐grounded bow‐tie transceiver array for cardiac MR at 7.0T

Advanced Radio Frequency Applicators for Thermal Magnetic Resonance Theranostics of Brain Tumors

Experimental Validation of the MRcollar: An MR Compatible Applicator for Deep Heating in the Head and Neck Region

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