Black chokeberry Aronia melanocarpa extract reduces blood pressure, glycemia and lipid profile in patients with metabolic syndrome: a prospective controlled trial

Tasić, Nebojša; Jakovljević, Vladimir; Mitrović, Miroslav; Djindjić, Boris; Tasić, Danijela; Dragisic, Dalibor; Citakovic, Zoran; Kovačević, Zorana; Radoman, Kristina; Živković, Vladimir; Bolevich, Sergey; Turnic, Tamara Nikolic

doi:10.1007/s11010-021-04106-4

Cited by 19 publications

(43 citation statements)

References 38 publications

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“…This effect of MET on weight loss was shown in both PCOS women [ 43 ] and animal studies [ 44 ]. Furthermore, there was a confirmed effect of SAE administration on BW loss in male rats with metabolic syndrome [ 17 ], as well as in male and female patients with metabolic syndrome and diabetes mellitus [ 19 ]. In the mentioned study, 2 weeks of SAE treatment significantly reduced BW in male diabetic patients, while after 4 weeks of SEA administration, BW was significantly reduced in both female and male patients.…”

Section: Discussionmentioning

confidence: 99%

“…The following individual compounds were found in SAE: 2.68 cyanidin 3-galactoside (80.40 mg/mL), 0.16 cyanidin 3-glucoside (4.92 mg/mL), 0.66 cyanidin 3-arabinoside (19.71 mg/mL), 0.14 cyanidin 3-xyloside (4.26 mg/mL), 0.12 rutin (3.55 mg/mL), 0.27 hyperoside (8.12 mg/mL), and 0.15 isoquercetin (4.36 mg/mL). The total amount of polyphenols was 410 mg/30 mL of SAE with a total energy value of 502.47 kJ (118.23 kcal)/100 mL [ 19 ].…”

Section: Methodsmentioning

confidence: 99%

“…Furthermore, our previous results even confirmed the protective role of SEA in hemodialysis patients with anemia [ 18 ]. Interestingly, SEA improved clinical and biochemical parameters in patients with confirmed metabolic syndrome even to a greater extent in women compared to men [ 19 ], probably involving the role of sex hormones on lipid metabolism. These data led us to an idea to explore the potential benefits of SEA administration in an androgen-induced PCOS rat model previously established in our laboratory [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Antioxidative Effects of Standardized Aronia melanocarpa Extract on Reproductive and Metabolic Disturbances in a Rat Model of Polycystic Ovary Syndrome

et al. 2022

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Polycystic ovary syndrome (PCOS) represents the most common endocrinopathy among childbearing-age women, with oxidative stress (OS) underlying its etiopathogenesis. Metformin (MET) represents a frequently used agent in PCOS. However, weak results encourage alternative treatments. We aimed to investigate isolated and synergistic effects of Standardized Aronia melanocarpa extract (SEA) and MET for alleviating reproductive and metabolic PCOS abnormalities. PCOS induction was followed by 28-day treatment with MET, SAE, or MET + SEA. Bodyweight (BW), cyclicity, histological, and ultrasonographical ovarian analyses were performed. Hormonal, glycemic, and lipid profiles were accessed, as well as systemic and ovarian oxidative status; BW, cyclicity, ovarian histomorphology, ovarian volume, testosterone and progesterone levels, as well as LDL, triglycerides, and total cholesterol levels were aggravated after PCOS-induction and improved after MET, SEA, and MET + SEA treatment. MET + SEA had the greatest impact on glycoregulation. Alterations in OS parameters (TBARS, O2−, H2O2, catalase, superoxide dismutase, and reduced glutathione) could be responsible for observed differences; (4) Conclusions: Our findings confirmed that SAE alone or along with MET was capable of ameliorating reproductive and metabolic disturbances in the PCOS rat model, with the restoration of OS parameters. SAE alone did not alter the protective effects of MET in PCOS.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antioxidative Effects of Standardized Aronia melanocarpa Extract on Reproductive and Metabolic Disturbances in a Rat Model of Polycystic Ovary Syndrome

et al. 2022

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“…Data from studies in humans are summarized in Table 1. In a study by Tasic et al (2021), the authors observed decreased BMI in a group of men with metabolic syndrome (with diabetes) as well as decreased waist circumference (WC) and body weight (BW) in each group after 4 weeks of supplementation with chokeberry extract [71]. In turn, in a study by Kardum, Petrović-Oggiano et al (2014) there was a decrease in WC, and BMI, and a downward trend in the case of BW [72].…”

Section: Impact Of Chokeberry On Anthropometric Measurementsmentioning

confidence: 99%

“…Table 2 summarizes the studies conducted in humans. In the study by Tasic et al (2021), the effects of supplementation with a standardized chokeberry extract (30 mL daily) on fasting glucose levels in patients with metabolic syndrome (MetS) without DM2 and with MetS connected with DM2 were investigated. The intervention lasted 4 weeks, while the level of glucose and other components was measured after 2 and 4 weeks of intervention.…”

Section: Impact Of Chokeberry On Carbohydrate Metabolismmentioning

confidence: 99%

Chokeberry (A. melanocarpa (Michx.) Elliott)—A Natural Product for Metabolic Disorders?

2022

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Abnormal metabolism of substances in the body can result in metabolic disorders which include obesity, cardiovascular diseases, diabetes, hypertension, chronic kidney disease, liver disease, or cancer. Foods rich in antioxidants can help to prevent and treat various types of disorders. Chokeberry fruits are rich in polyphenols, especially cyanidins, and therefore, can show a beneficial health effect. The aim of this study was to summarize and systematize reports about the effects of chokeberry on various metabolic parameters. Studies from 2000 to 2021, published in the PubMed and Google Scholar databases, were reviewed. The review of studies shows that chokeberry may have a positive effect in dyslipidemia and hypertension and may increase the body’s antioxidant defense mechanisms. The anti-inflammatory effect, in turn, may translate into a reduction in the risk of metabolic disorders over a longer period of use. Changes in glucose levels were reported by studies in which the intervention lasted more than 10 weeks in patients with carbohydrate metabolism disorders. The effects of protecting the liver, inhibiting platelet aggregation, lowering uric acid levels, and having a protective effect on the kidneys require additional confirmation in human clinical trials. Consumption of chokeberry fruit did not impact on anthropometric measurements; however, it seems that chokeberry fruit can be recommended in many metabolic disorders due to the richness of bioactive ingredients.

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Impact of dietary supplementation with chokeberry (Aronia melanocarpa, Michx.) on tetrachloride‐induced liver injury in Wistar rats: Hematological and biochemical implication

Suljević

Mitrašinović-Brulić

Klepo

et al. 2023

Cell Biochemistry & Function

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In the current study, we assessed the hematological/biochemical alterations, histopathological changes in the liver, and blood cell disorders in Wistar rats exposed to a toxic concentration of carbon tetrachloride (CCl4) and the potential protective effect of a 30‐day oral extract of chokeberry (Aronia melanocarpa, AM). The concentration of AM (3.38 mg/kg) obtained by quantitative purification from AM fruit showed the highest antioxidant activity (AOA) in vitro and was used for oral ingestion. In addition to high AOA, high values of total phenols (85.334 mg/g), total phenolic acid (606.95 mg/g), total flavonids (22.10 mg/g), and total anthocyanins (11.01 mg/g) were recorded in chokeberry extract. CCl4 treatment caused serious liver injury, hepatocyte and blood cell impairment. AM extract given to rats before CCl4 application had a moderate hepatoprotective effect in comparison to after CCl4 application. White blood count and leukocytes were significantly altered by CCl4, however, the protective role of AM in leukocyte disorders was not established. A high number of microcytes, stomatocytes, anisocytes, and hemolyzed erythrocytes during CCl4 exposure was reduced by AM extract. Flower erythrocytes in the AM + CCl4 group were recorded. Supplementation with chokeberry extract without CCl4 caused hyperproteinemia and hyperalbuminemia. Although the results indicate a weak protective role for AM, it is nevertheless important for improved erythropoiesis and regulation of the development of anemia. The hepatoprotective role of AM was moderate, and the immune response was not proven. Daily consumption of chokeberry extract can improve health. However, the results of our study showed that the ingestion of AM extract at this dose with the highest AOA would have more effective effects if the supplementation were significantly increased.

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Black chokeberry Aronia melanocarpa extract reduces blood pressure, glycemia and lipid profile in patients with metabolic syndrome: a prospective controlled trial

Cited by 19 publications

References 38 publications

Antioxidative Effects of Standardized Aronia melanocarpa Extract on Reproductive and Metabolic Disturbances in a Rat Model of Polycystic Ovary Syndrome

Antioxidative Effects of Standardized Aronia melanocarpa Extract on Reproductive and Metabolic Disturbances in a Rat Model of Polycystic Ovary Syndrome

Chokeberry (A. melanocarpa (Michx.) Elliott)—A Natural Product for Metabolic Disorders?

Impact of dietary supplementation with chokeberry (Aronia melanocarpa, Michx.) on tetrachloride‐induced liver injury in Wistar rats: Hematological and biochemical implication

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