Development of a pediatric liver CEUS criterion to classify benign and malignant liver lesions in pediatric patients: a pilot study

Wang, Guotao; Xie, Xiaohua; Chen, Huadong; Zhong, Zhihai; Zhou, Wenying; Jiang, Hong; Xie, Xian-Jin; Zhou, Luyao

doi:10.1007/s00330-021-07784-2

Cited by 5 publications

(3 citation statements)

References 24 publications

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“…This phase occurs long after injection since Sonazoid is phagocytized by Kupffer cells and remains longer in the liver. Study shows that hemangiomas with or without high flow rate tend to become iso-or hypotensive in the Kupffer phase [39].…”

Section: Figure 1: Contrast Enhancement Patternsmentioning

confidence: 94%

Contrast-Enhanced Ultrasound as a Main Radiological Diagnostic Method for Primary Liver Neoplasms and Hemangiomas

Hakobyan¹,

Gaddam²,

Ojinnaka³

et al. 2021

Cureus

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Contrast-enhanced ultrasound (CEUS) is a relatively new approach for the definitive diagnosis of focal liver lesions (FLL). The essential advantages of CEUS are affordability, absence of radiation, and negligible nephrotoxicity-making this diagnostic approach more preferable. This review includes data from 39 different research studies published during the last 10 years, selected through the MeSH strategy in PubMed.We conclude that CEUS is a promising approach for diagnosing primary liver neoplasms and it is an excellent radiological approach for children and pregnant women because of the absence of radiation and nephrotoxicity. Studies showed that CEUS is a very good approach for the differentiation of a variety of hemangiomas and for a detailed description of those findings. Therefore, CEUS is an important and progressive method for the diagnosis of liver neoplasms. The regular use of CEUS will facilitate the diagnosis of primary liver lesions.

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Section: Figure 1: Contrast Enhancement Patternsmentioning

confidence: 94%

Contrast-Enhanced Ultrasound as a Main Radiological Diagnostic Method for Primary Liver Neoplasms and Hemangiomas

Hakobyan¹,

Gaddam²,

Ojinnaka³

et al. 2021

Cureus

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“…Color Doppler US is a valuable modality for identifying potential invasion of the hepatic and portal veins [74]. On CEUS, the special features of hepatoblastoma include initial peripheral hyperenhancement during the arterial phase and pronounced wash-out in the subsequent late portal venous phase (fig 3 , fig 4) [75].…”

Section: B-us and Ceusmentioning

confidence: 99%

Comments on and illustrations of the WFUMB CEUS liver guidelines: Rare malignant neuroendocrine and predominant epithelioid liver lesions

Zadeh,

Huber,

Görg

et al. 2024

Med Ultrason

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The diagnosis or rare, non-hematologic malignant lesions of the liver may be a challenge owing to the rarity of the disease, and is usually made by histological confirmation. Ultrasound with color Doppler and contrast-enhanced, if required, taking into account the clinical background of the patient, may help to focus the differential diagnosis. In this review, we describe the pathological and ultrasound features of rare malignant neuroendocrine and predominantly epithelioid liver lesions including primary neuroendocrine tumor of the liver, Invasive mucinous cystic neoplasm of the liver, and also hepatoblastoma.

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“…During the late portal venous phase, it shows marked washout [17,60]. Wang et al [61] analyzed the CEUS features of FLLs in pediatric patients. Their results showed CEUS features of hyperenhancement during the arterial phase and early washout (≤45 s), and showed a sensitivity of 90.7% and specificity of 93.6% to predict hepatoblastoma in pediatric patients <5 years.…”

Section: Imaging Featuresmentioning

confidence: 99%

Review on Pediatric Malignant Focal Liver Lesions with Imaging Evaluation: Part I

Dong,

Cekuolis,

Schreiber-Dietrich

et al. 2023

Diagnostics

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Malignant focal liver lesions (FLLs) are commonly reported in adults but rarely seen in the pediatric population. Due to the rarity, the understanding of these diseases is still very limited. In children, most malignant FLLs are congenital. It is very important to choose appropriate imaging examination concerning various factors. This paper will outline common pediatric malignant FLLs, including hepatoblastoma, hepatocellular carcinoma, and cholangiocarcinoma and discuss them against the background of the latest knowledge on comparable/similar tumors in adults. Medical imaging features are of vital importance for the non-invasive diagnosis and follow-up of treatment of FLLs in pediatric patients. The use of CEUS in pediatric patients for characterizing those FLLs that remain indeterminate on conventional B mode ultrasounds may be an effective option in the future and has great potential to be integrated into imaging algorithms without the risk of exposure to ionizing radiation.

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Development of a pediatric liver CEUS criterion to classify benign and malignant liver lesions in pediatric patients: a pilot study

Cited by 5 publications

References 24 publications

Contrast-Enhanced Ultrasound as a Main Radiological Diagnostic Method for Primary Liver Neoplasms and Hemangiomas

Contrast-Enhanced Ultrasound as a Main Radiological Diagnostic Method for Primary Liver Neoplasms and Hemangiomas

Comments on and illustrations of the WFUMB CEUS liver guidelines: Rare malignant neuroendocrine and predominant epithelioid liver lesions

Review on Pediatric Malignant Focal Liver Lesions with Imaging Evaluation: Part I

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