“…In humans, orf virus causes vesicles, pustules, painful erythematous, violaceous plaques, erythematous maculopapular lesions, targetoid bulla, weeping nodule, crusted papule, papilloma, ulceration, desquamation, or sometimes non-pruritic purulent yellow-whitish nodules, which usually occur on hands, fingers, and arms and can be single or multiple (70,99,117,163,185,193). Orf may lead to the formation of hyperkeratotic nodules underneath fingernails, and erythematous, centrally ulcerated, hemorrhagic fragile nodules, and papillomatous projections on the face (71,72). A nodular mass with erythema on the nose caused by orf virus infection is also reported (14).…”