Factors Associated with COVID-19 and Asymptomatic Carriage in Healthcare Workers of a COVID-19 Hospital

Ochoa‐Hein, Eric; Leal-Morán, Patricia E; Vargas-Fernández, Abril T; González-Lara, María Fernanda; Alberto-Hernández, María F; Bustos-Román, Daniel E; Valverde-Ramos, Lirio N; Ramos-Cervantes, Pilar; Cervantes-Villar, Luz Elena; Ibarra-González, Violeta; Ponce-de-León, Alfredo; Kershenobich-Stalnikowitz, David; Sifuentes–Osornio, José

doi:10.24875/ric.20000592

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…Interestingly, nurses and kitchen workers were overly represented in the reinfection group. Although the cause of this is unclear, two factors could underlie a possible increase in reinfection risk: (1) these groups were among those most infected during the initial pandemic wave in Mexico 16 and (2) many female nurses are also homemakers (a factor known to confer an increased risk in Mexico) 17 .…”

Section: Discussionmentioning

confidence: 99%

Significant rise in SARS-CoV-2 reinfection rate in vaccinated Hospital workers during the omicron wave: A prospective cohort study

Ochoa‐Hein¹,

Leal-Morán²,

Nava-Guzmán³

et al. 2022

RIC

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Background: Relatively low SARS-CoV-2 reinfection rates have been reported in vaccinated individuals, but updates considering the Omicron variant are lacking. Objective: The objective of the study was to provide a current estimate of the SARS-CoV-2 reinfection rate in a highly immunized population. Methods: A prospective cohort of Mexican hospital workers was followed (March 2020-February 2022). Reinfection was defined as the occurrence of two or more episodes of COVID-19 separated by a period of ≥ 90 days without symptoms. The reinfection rate was calculated as the number of reinfection episodes per 100,000 persons per day. Results: A total of 3732 medical consultations were provided to 2700 workers, of whom 1388 (51.4%) were confirmed COVID-19 cases. A total of 73 reinfection cases were identified, of whom 71 (97.3%) had completed their primary vaccination series and 22 (30.1%) had had a booster dose before the second episode. The overall reinfection rate was 23.1 per 100,000 persons per day (as compared to a rate of 1.9 per 100,000 persons per day before the Omicron wave). Conclusions: The SARS-CoV-2 reinfection rate rose significantly during the Omicron wave despite a high primary vaccination coverage rate. Almost one-third of reinfected workers had a vaccine booster ≥ 14 days before the last

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Section: Discussionmentioning

confidence: 99%

Significant rise in SARS-CoV-2 reinfection rate in vaccinated Hospital workers during the omicron wave: A prospective cohort study

Ochoa‐Hein¹,

Leal-Morán²,

Nava-Guzmán³

et al. 2022

RIC

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“…It has been identified that a large part of the population is asymptomatic of the disease; that is, they do not present any apparent clinical symptoms, which can favor the spread of the infection [ 8 ]. A high prevalence of asymptomatic infections has been documented in various regions worldwide, encompassing countries across Asia, Europe, Africa [ 9 – 12 ], and the Americas, including Mexico [ 13 ]. These individuals, who are primarily mostly young adults [ 9 , 14 ], workers, health care workers, or household breadwinners may be one of the biggest obstacles in containing the COVID-19 pandemic [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of IgM/IgG and Neutralizing Antibodies against SARS-CoV-2 in Unvaccinated Young Adults from Mexico Who Reported Not Having Had a Previous COVID-19 Infection

Padilla-Bórquez,

Matuz-Flores,

Hernández-Bello

et al. 2024

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Background. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that causes coronavirus disease 2019 (COVID-19). It is estimated that more than half of new infections are transmitted by asymptomatic people; therefore, the isolation of symptomatic people is not enough to control the spread of the disease. Methods. A total of 171 unvaccinated young adults (18–35 years) from Sonora, Mexico, who underwent a structured survey to identify prior COVID-19 infections, were included in this study. A qualitative determination of anti-SARS-CoV-2 antibodies in serum was performed by lateral flow immunoassay (Certum IgG/IgM Rapid Test™ cassette kit) and neutralizing antibodies were also determined (GenScript cPass assay). Results. A total of 36 people reported a history of COVID-19 infection, and 135 reported no history of COVID-19. In contrast, 49.6% (67/135) of individuals who had not reported a previous SARS-CoV-2 infection were seropositive to the rapid anti-SARS-CoV-2 antibody test, and 48.1% (65/135) of them had neutralizing antibodies. Conclusions. These results suggest that in young adults, SARS-CoV-2 infections could be asymptomatic in a high percentage of individuals, which could contribute in part to the slow control of the current pandemic due to the large number of asymptomatic cases that are contagious and that could be a silent spread of the virus.

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“…However, confirmed positive cases decreased slightly to 6,037,742 in the country in 2022 [3]. Direct contact with COVID-19 sufferers [4], history of 21 co-morbidities [5], workplace [4], age ≥80 years [6], [7] presence of clinical symptoms [8], and sex [9] risk factors that have the potential to contract COVID-19. However, other studies have reported this age [4], [10], sex [6], and no clinical symptoms is not a risk factor that can trigger transmission and death from COVID-19.…”

Section: Introductionmentioning

confidence: 99%

Risk factors of COVID-19 disease confirmed cases in Solok District

Nuraisyah,

Irjayanti,

Irmanto

et al. 2024

IJPHS

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According to West Sumatra corona virus data, Solok Regency has the highest prevalence of positive confirmed cases of COVID-19 in West Sumatra, and one of the areas where the prevalence has increased significantly. Analysis of risk factors for COVID-19 cases in Solok Regency in 2021. We conducted a cross-sectional study analysis of secondary data from March to December 2020 with a mass randomized trial using the polymerase chain reaction (PCR) test in Solok Regency. Descriptive statistical analysis was used with secondary data relevant, and a logistic regression model was used to assess infection risk factors. A total of the 770 participants, 47.4% were women and 66% were aged 50-64 years. A total of 624 participants tested (81.03%) were identified as asymptomatic PCR SARS-CoV infection without symptoms, with 88% of participants with co-morbidities and 66% of participants without travel history. Based on the results obtained a significant relationship between history of comorbidities (p-value=0.00; AOR=0.16; 95% CI=0.08-0.32), clinical symptoms (p-value=0.00; AOR=0.04; 95% CI=0.03-0.08), and travel history (p-value=0.00, AOR=1.80, 95% CI=1.25-2.61). The majority of cases that were confirmed positive for COVID-19 based on the PCR test showed no symptoms, with co-morbidities and travel history. Confirmed positive cases of COVID-19 are associated with co-morbidities, symptoms and travel history.

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Factors Associated with COVID-19 and Asymptomatic Carriage in Healthcare Workers of a COVID-19 Hospital

Cited by 3 publications

References 11 publications

Significant rise in SARS-CoV-2 reinfection rate in vaccinated Hospital workers during the omicron wave: A prospective cohort study

Significant rise in SARS-CoV-2 reinfection rate in vaccinated Hospital workers during the omicron wave: A prospective cohort study

Seroprevalence of IgM/IgG and Neutralizing Antibodies against SARS-CoV-2 in Unvaccinated Young Adults from Mexico Who Reported Not Having Had a Previous COVID-19 Infection

Risk factors of COVID-19 disease confirmed cases in Solok District

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