Ingredients such as trehalose and hesperidin taken as supplements or foods reverse alterations in human T cells, reducing asbestos exposure-induced antitumor immunity

Yamamoto, Shoko; Lee, Sai Peck; Ariyasu, Toshio; Endo, Shin; Miyata, Satomi; Yasuda, Akiko; Harashima, Akira; Ohta, Toshio; Kumagai-Τakei, Naoko; Itö, Tatsuo; Shimizu, Yurika; Srinivas, Bandaru; Sada, Nagisa; Nishimura, Yasumasa; Otsuki, Takemi

doi:10.3892/ijo.2021.5182

Cited by 5 publications

(3 citation statements)

References 57 publications

(32 reference statements)

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“…Glycyrrhizin, one of the main components, regulates antitumor immunity by attenuating Tregs and MDSCs ( Juin et al, 2020 ). Another component, hesperidin, may restore antitumor immunity in T helper cells ( Yamamoto et al, 2021 ). Furthermore, network pharmacological analysis using 70 BJIKT-associated CRC genes suggests that BJIKT is closely related to the regulation of immune responses, T-cell-associated immunity, NK cell activation, and myeloid differentiation through multiple targets.…”

Section: Discussionmentioning

confidence: 99%

Bojungikki-Tang Improves Response to PD-L1 Immunotherapy by Regulating the Tumor Microenvironment in MC38 Tumor-Bearing Mice

Chun

Park

et al. 2022

Front. Pharmacol.

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Immune checkpoint blockage targeting PD-L1 has led to breakthroughs in cancer treatment. Although anti-PD-L1-based immunotherapy has been approved as standard therapy in various cancer types, its therapeutic efficacy in most colorectal cancers (CRC) is still limited due to the low response to immunotherapy. Therefore, combining treatment with herbal medicines could be an alternative approach for treating CRC to overcome this limitation. Bojungikki-Tang (BJIKT), a herbal formula used in traditional Chinese medicine, clinically improves the quality of life for cancer patients and has been associated with antitumor and immune-modulating activities. However, the regulatory effect of BJIKT on the immune response in the tumor microenvironment remains largely uninvestigated. In this study, we verified the inhibitory effect of BJIKT on tumor growth and investigated the regulatory effect of combination therapy with BJIKT and anti-PD-L1 on antitumor immune responses in an MC38 CRC-bearing C57BL/6 mouse model. Immune profiling analysis by flow cytometry was used to characterize the exact cell types contributing to anticancer activities. Combination treatment with BJIKT and anti-PD-L1 therapy significantly suppressed tumor growth in MC38-bearing mice and increased the proportion of cytotoxic T lymphocytes and natural killer cells in tumor tissues. Furthermore, BJIKT suppressed the population of myeloid-derived suppressor cells, suggesting that this combination treatment effectively regulates the immunological function of T-cells by improving the tumor microenvironment. The herbal formula BJIKT can be a novel therapeutic option for improving anti-PD-L1-based immunotherapy in patients with CRC.

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Section: Discussionmentioning

confidence: 99%

Bojungikki-Tang Improves Response to PD-L1 Immunotherapy by Regulating the Tumor Microenvironment in MC38 Tumor-Bearing Mice

Chun

Park

et al. 2022

Front. Pharmacol.

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“…Dietary phytochemicals, such as hesperidin, are considered to contribute to cancer prevention (37,38). The safety of hesperidin and its anticancer activity have been previously demonstrated (41,65,66). The intervention of hesperidin in TS-induced abnormal pulmonary EMT and cell proliferation is through the p38 pathway, where phosphorylated p38 and phosphorylated c-Fos are attenuated by hesperidin.…”

Section: Discussionmentioning

confidence: 99%

Hesperidin inhibits tobacco smoke‑induced pulmonary cell proliferation and EMT in mouse lung tissues via the p38 signaling pathway

Liang

Zhang

et al. 2022

Oncol Lett

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Tobacco smoke (TS) is the major cause of lung cancer. The abnormal proliferation and epithelial-mesenchymal transition (EMT) of lung cells promote occurrence and development of lung cancer. The p38 pathway intervenes in this cancer development. Hesperidin also serves a role in human health and disease prevention. The roles of p38 in TS-mediated abnormal cell proliferation and EMT, and the hesperidin intervention thereof are not yet understood. In the present study, it was demonstrated that TS upregulated proliferating cell nuclear antigen, vimentin and N-cadherin expression, whereas it downregulated E-cadherin expression, as assessed using western blotting and reverse transcription-quantitative PCR. Furthermore, it was observed that inhibition of the p38 pathway inhibit TS-induced proliferation and EMT. Hesperidin treatment prevented the TS-induced activation of the p38 pathway, EMT and cell proliferation in mouse lungs. The findings of the present study may provide insights into the pathogenesis of TS-related lung cancer.

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“…Glycyrrhizin, one of the main components, regulates antitumor immunity by attenuating Tregs and MDSCs (Juin et al, 2020). Another component, hesperidin, may restore antitumor immunity in T helper cells (Yamamoto et al, 2021). Furthermore, network pharmacological analysis using 70 BJIKTassociated CRC genes suggests that BJIKT is closely related to the regulation of immune responses, T-cell-associated immunity, NK cell activation, and myeloid differentiation through multiple targets.…”

Section: Discussionmentioning

confidence: 99%

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Ingredients such as trehalose and hesperidin taken as supplements or foods reverse alterations in human T cells, reducing asbestos exposure-induced antitumor immunity

Cited by 5 publications

References 57 publications

Bojungikki-Tang Improves Response to PD-L1 Immunotherapy by Regulating the Tumor Microenvironment in MC38 Tumor-Bearing Mice

Bojungikki-Tang Improves Response to PD-L1 Immunotherapy by Regulating the Tumor Microenvironment in MC38 Tumor-Bearing Mice

Hesperidin inhibits tobacco smoke‑induced pulmonary cell proliferation and EMT in mouse lung tissues via the p38 signaling pathway

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