Gynaecological cancers and their cell lines

Abstract

Cell lines are widely used for various research purposes including cancer and drug research. Recently, there have been studies that pointed to discrepancies in the literature and usage of cell lines. That is why we have prepared a comprehensive overview of the most common gynaecological cancer cell lines, their literature, a list of currently available cell lines, and new findings compared with the original studies. A literature review was conducted via MEDLINE, PubMed and ScienceDirect for reviews in the last 5 years to identify research and other studies related to gynaecological cancer cell lines. We present an overview of the current literature with reference to the original studies and pointed to certain inconsistencies in the literature. The adherence to culturing rulesets and the international guidelines helps in minimizing replication failure between institutions. Evidence from the latest research suggests that despite certain drawbacks, variations of cancer cell lines can also be useful in regard to a more diverse genomic landscape.

Identification and subsequent validation of transcriptomic signature associated with metabolic status in endometrial cancer

“…The DEG expression profile of non-treated human EC cell lines (AN3-CA, COLO 684, EFE-184, EN, HEC-1A, HEC-1B, Ishikawa, JHUEM-1, JHUEM-2, JHUEM-3, JHUEM-7, KLE, MFE-280, MFE-296, MFE-319, RL95-2, SNU-685, SNU-1077, TEN) was included. ECC-1 cell line has been excluded as it has been suggested to be a derivative of Ishikawa 3-H-12 or MCF-7 cells due to the contamination 84 .…”

Tumor Organoid and Spheroid Models for Cervical Cancer

“…However, it has to be considered that, despite the widely accepted standards for regulation, the criteria for the characterization of cell lines derived from cervical neoplasia continue to change. Most in vitro studies on cervical cancer have been completed on HeLa, CaSki, SiHa, or C-33-A cell lines [13].…”

MFUM-BrTNBC-1, a Newly Established Patient-Derived Triple-Negative Breast Cancer Cell Line: Molecular Characterisation, Genetic Stability, and Comprehensive Comparison with Commercial Breast Cancer Cell Lines

“…Nevertheless, CLs mirror the original tumours from which they were derived, making them valuable tools for studying molecular aberrations and molecular pathways [ 14 ]. With regard to the latter, CLs provide an opportunity to gain further information about the pathophysiology of TNBC and the efficacy of its pharmacotherapeutic treatment [ 15 ]. These in vitro model systems are used in various scientific and medical fields, especially in basic cancer research and drug discovery [ 16 , 17 , 18 , 19 , 20 ].…”