Reported autism diagnosis is associated with psychotic-like symptoms in the Adolescent Brain Cognitive Development cohort

Jutla, Amandeep; Donohue, Meghan Rose; Veenstra‐VanderWeele, Jeremy; Foss‐Feig, Jennifer H.

doi:10.1007/s00787-021-01738-1

Cited by 8 publications

(10 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Here, one potential path forward is consortia that pool data from many participants that have been collected and processed in a standardized way. For example, we were recently able to explore the relationships between ASD diagnosis, psychotic symptoms, and resting‐state connectivity within the large adolescent brain cognitive development (ABCD) dataset (Jutla et al, 2021; Jutla, Foss‐Feig, et al, 2020). At the genetic level, such large‐scale projects will also be helpful, particularly given the very large sample sizes required to identify statistical significance.…”

Section: Discussionmentioning

confidence: 99%

“…The overlap between ASD and SCZ is particularly relevant when considering which youth with ASD are at risk of developing SCZ. Our group, in a study of the large U.S. Adolescent Brain Cognitive Development cohort, found that a parent‐reported autism diagnosis was a strong predictor of psychotic symptoms in middle childhood (Jutla et al, 2021). Work in the Avon Longitudinal Study of Parents and Children has found the same relationship in early adolescence (Sullivan et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Autism spectrum disorder and schizophrenia: An updated conceptual review

2021

Self Cite

View full text Add to dashboard Cite

Autism spectrum disorder (ASD) and schizophrenia (SCZ) are separate disorders, with distinct clinical profiles and natural histories. ASD, typically diagnosed in childhood, is characterized by restricted or repetitive interests or behaviors and impaired social communication, and it tends to have a stable course. SCZ, typically diagnosed in adolescence or adulthood, is characterized by hallucinations and delusions, and tends to be associated with declining function. However, youth with ASD are three to six times more likely to develop SCZ than their neurotypical counterparts, and increasingly, research has shown that ASD and SCZ converge at several levels. We conducted a systematic review of studies since 2013 relevant to understanding this convergence, and present here a narrative synthesis of key findings, which we have organized into four broad categories: symptoms and behavior, perception and cognition, biomarkers, and genetic and environmental risk. We then discuss opportunities for future research into the phenomenology and neurobiology of overlap between ASD and SCZ. Understanding this overlap will allow for researchers, and eventually clinicians, to understand the factors that may make a child with ASD vulnerable to developing SCZ. Lay Summary Autism spectrum disorder and schizophrenia are distinct diagnoses, but people with autism and people with schizophrena share several characteristics. We review recent studies that have examined these areas of overlap, and discuss the kinds of studies we will need to better understand how these disorders are related. Understanding this will be important to help us identify which autistic children are at risk of developing schizophrenia.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Autism spectrum disorder and schizophrenia: An updated conceptual review

2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Psychosis expression is prevalent in young individuals, with around 17% of children (ages 9–12 years) from the general population reporting psychotic experiences ( 45 ). The persistence and worsening of psychosis phenotypes is related to impairment, other psychopathology, and genetic as well as environmental vulnerability ( 43 , 46 , 47 , 48 , 49 , 50 ). Early psychosis expression may signal an early stage of psychopathology in young individuals, accompanied by a heterogeneous and nonspecific manifestation of clinical symptoms ( 35 , 44 , 45 , 51 , 52 , 53 ).…”

mentioning

confidence: 99%

Estimating the Association Between Exposome and Psychosis as Well as General Psychopathology: Results From the ABCD Study

Pries

Moore

Visoki

et al. 2022

Biological Psychiatry Global Open Science

View full text Add to dashboard Cite

“…Notably, three previous studies have also shown that (for as of yet unknown reasons) autistic individuals reported more distress when experiencing psychotic symptoms than non-autistic peers. 9,53,54 These distressing and/or frequent psychotic experiences appear to be most strongly related to negative mental health consequences, such as the development of psychotic disorder. 38 Still, thus far there has been little work examining how these psychotic experiences can be best identified and addressed in individuals with autistic traits, and more work is needed in this area.…”

Section: Discussionmentioning

confidence: 99%

Childhood Trauma As a Mediator of the Association Between Autistic Traits and Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children Cohort

Dardani

Schalbroeck

Madley‐Dowd

et al. 2022

Schizophrenia Bulletin

View full text Add to dashboard Cite

Background Little is known on whether associations between childhood autistic traits and psychotic experiences persist into adulthood and whether genetic confounding and childhood trauma influence them. Here we investigate the associations between childhood autistic traits and psychotic experiences until young adulthood and assess the influence of schizophrenia polygenic risk and childhood traumatic experiences, using the Avon Longitudinal Study of Parents and Children (ALSPAC) population-based birth cohort. Study design We used a measure of broad autistic traits (autism factor mean score), and four dichotomised measures of autistic traits capturing social communication difficulties (age 7), repetitive behaviours (age 5), sociability (age 3), and pragmatic language (age 9). Psychotic experiences were assessed at ages 18 and 24 using the semi-structured Psychosis-Like Symptoms interview (PLIKSi). Traumatic experiences between ages 5 and 11 were assessed with questionnaires and interviews administered to children and parents at multiple ages. Study results Broad autistic traits, as well as social communication difficulties, were associated with psychotic experiences that were distressing and/or frequent until age 24 (autism factor mean score, n = 3707: OR 1.19, 95%CI 1.01–1.39; social communication difficulties, n = 3384: OR 1.54, 95%CI 0.97–2.45). Childhood trauma mediated a substantial proportion of the identified associations (~28% and 36% respectively, maximum n = 3577). Schizophrenia polygenic risk did not appear to confound the associations. Multiple imputation analyses (maximum n = 13 105) yielded comparable results. Conclusions Childhood trauma may be an important, potentially modifiable pathway between autistic features and later onset of psychotic psychopathology.

show abstract

Reported autism diagnosis is associated with psychotic-like symptoms in the Adolescent Brain Cognitive Development cohort

Cited by 8 publications

References 57 publications

Autism spectrum disorder and schizophrenia: An updated conceptual review

Autism spectrum disorder and schizophrenia: An updated conceptual review

Estimating the Association Between Exposome and Psychosis as Well as General Psychopathology: Results From the ABCD Study

Childhood Trauma As a Mediator of the Association Between Autistic Traits and Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children Cohort

Contact Info

Product

Resources

About