Mode of delivery and long-term gastrointestinal-related hospitalization of the offspring

Davidesko, Sharon; Alioshin, Alexander; Walfisch, Asnat; Wainstock, Tamar; Yerushalmi, Baruch

doi:10.1080/14767058.2021.1892636

Cited by 2 publications

(2 citation statements)

References 38 publications

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“…The involvement of anesthesia as well as laparotomy during a cesarean delivery increases the risk for maternal morbidity, such as bleeding and infections 22,23 . Cesarean delivery has been associated with increased morbidity of the offspring in the long term in previous studies 24–26 . Therefore, reconsideration by the clinicians of the indications for cesarean delivery in short‐stature patients is warranted in order to lessen the rising rate of cesarean delivery.…”

Section: Discussionmentioning

confidence: 99%

“…22,23 Cesarean delivery has been associated with increased morbidity of the offspring in the long term in previous studies. [24][25][26] Therefore, reconsideration by the clinicians of the indications for cesarean delivery in short-stature patients is warranted in order to lessen the rising rate of cesarean delivery. Although short stature may be associated with a smaller pelvic inlet, it can be speculated that the higher rate of cesarean delivery is partially attributed to caregiver bias.…”

Section: Discussionmentioning

confidence: 99%

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Obstetric and perinatal outcome in short‐stature patients

Leybovitz-Haleluya

Wainstock

2023

Intl J Gynecology & Obste

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ObjectiveScarce data exist regarding obstetric complications of short‐stature patients. This study aimed to investigate obstetric and perinatal outcomes in women with short stature; specifically, to investigate whether short‐stature patients are at an increased risk for cesarean delivery.MethodsA population‐based cohort study was conducted, including all singletons born between the years 1991 and 2021 at a tertiary medical center. Obstetric and perinatal outcomes of short‐stature patients were compared with those of non‐short patients. A generalized estimation equation binary logistic model was constructed to adjust for confounders and maternal recurrence in the cohort.ResultsThe study population included 356 356 parturient; among them, 14 035 (3.9%) were short‐stature patients. Short‐stature patients had significantly higher rates of cesarean delivery (20.7% vs 13.7%, odds ratio = 1.64, 95% confidence interval 1.57–1.71, P < 0.001), induction of labor, pathologic presentations, prolonged second stage of labor, non‐reassuring fetal monitoring, and meconium‐stained amniotic fluid. Newborns of short‐stature patients had a significantly higher risk of being small for gestational age as compared with those of non‐short patients. In the generalized estimation equation models, the association between short stature and risk of cesarean delivery remained significant (adjusted odds ratio = 1.32, 95% confidence interval 1.27–1.38, P < 0.001), as well as the risk of small for gestational age newborns (adjusted odds ratio = 1.51, 95% confidence interval 1.40–1.63, P < 0.001), but not for the other adverse outcomes.ConclusionsMaternal short stature is an independent risk factor for cesarean delivery and is associated with small for gestational age newborns.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Obstetric and perinatal outcome in short‐stature patients

Leybovitz-Haleluya

Wainstock

2023

Intl J Gynecology & Obste

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Antibiotics, Analgesic Sedatives, and Antiseizure Medications Frequently Used in Critically Ill Neonates: A Narrative Review

Kontou,

Agakidou,

Chatziioannidis

et al. 2024

Children

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Antibiotic, analgesic sedative, and antiseizure medications are among the most commonly used medications in preterm/sick neonates, who are at high risk of nosocomial infections, central nervous system complications, and are exposed to numerous painful/stressful procedures. These severe and potentially life-threatening complications may have serious short- and long-term consequences and should be prevented and/or promptly treated. The reported variability in the medications used in neonates indicates the lack of adequate neonatal studies regarding their effectiveness and safety. Important obstacles contributing to inadequate studies in preterm/sick infants include difficulties in obtaining parental consent, physicians’ unwillingness to recruit preterm infants, the off-label use of many medications in neonates, and other scientific and ethical concerns. This review is an update on the use of antimicrobials (antifungals), analgesics (sedatives), and antiseizure medications in neonates, focusing on current evidence or knowledge gaps regarding their pharmacokinetics, indications, safety, dosage, and evidence-based guidelines for their optimal use in neonates. We also address the effects of early antibiotic use on the intestinal microbiome and its association with long-term immune-related diseases, obesity, and neurodevelopment (ND). Recommendations for empirical treatment and the emergence of pathogen resistance to antimicrobials and antifungals are also presented. Finally, future perspectives on the prevention, modification, or reversal of antibiotic resistance are discussed.

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Mode of delivery and long-term gastrointestinal-related hospitalization of the offspring

Cited by 2 publications

References 38 publications

Obstetric and perinatal outcome in short‐stature patients

Obstetric and perinatal outcome in short‐stature patients

Antibiotics, Analgesic Sedatives, and Antiseizure Medications Frequently Used in Critically Ill Neonates: A Narrative Review

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