2021
DOI: 10.1016/j.apsb.2020.08.006
|View full text |Cite
|
Sign up to set email alerts
|

Recent developments on PET radiotracers for TSPO and their applications in neuroimaging

Abstract: The 18 kDa translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor, is predominately localized to the outer mitochondrial membrane in steroidogenic cells. Brain TSPO expression is relatively low under physiological conditions, but is upregulated in response to glial cell activation. As the primary index of neuroinflammation, TSPO is implicated in the pathogenesis and progression of numerous neuropsychiatric disorders and neurodegenerative diseases, including Alzheimer's disease … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

1
83
0

Year Published

2021
2021
2023
2023

Publication Types

Select...
8

Relationship

1
7

Authors

Journals

citations
Cited by 98 publications
(91 citation statements)
references
References 220 publications
(159 reference statements)
1
83
0
Order By: Relevance
“…An electrical impedance measurement can be studied for the resealing of pores [ 236 ]. Depending on the skin’s occlusion and the geometry of the needle, it can take 2–40 h to recover [ 237 ]. TEWL and the shading of tissues can also be used for pores [ 238 ].…”
Section: Pharmacokinetic and Drug Release Behavior From Polymeric Mnsmentioning
confidence: 99%
“…An electrical impedance measurement can be studied for the resealing of pores [ 236 ]. Depending on the skin’s occlusion and the geometry of the needle, it can take 2–40 h to recover [ 237 ]. TEWL and the shading of tissues can also be used for pores [ 238 ].…”
Section: Pharmacokinetic and Drug Release Behavior From Polymeric Mnsmentioning
confidence: 99%
“…Radio-tracing is strongly expected to be used in the context of schizophrenia to enhance clinical evaluation. With respect to the microglial proteins monitored by PET tracers, the translocator protein 18 kDa (TSPO) has been targeted in neurological diseases, such as Alzheimer’s disease and multiple sclerosis [ 113 ]. However, TSPO tracers were reported to be unable to discriminate patients with schizophrenia from healthy controls [ 114 ].…”
Section: Potential Diagnosis/medication For Schizophrenia Based On Microglia–synapse Interactionmentioning
confidence: 99%
“…The 18 kDa translocator protein (TSPO, formerly referred to as the peripheral benzodiazepine receptor) is a highly conserved mitochondrial protein predominantly expressed in the outer mitochondrial membrane in steroid-synthesising tissues. [1] It forms part of a larger transmembrane complex (Fig. 1) that facilitates cholesterol translocation across the mitochondrial membranes (the rate-limiting step in steroid synthesis).…”
Section: Introductionmentioning
confidence: 99%
“…TSPO is thought to be involved in myriad other cellular processes, although we still lack a precise understanding of the full scope of its functions. [1] TSPO is upregulated in immune cells in response to harmful stimuli, and is therefore a reliable and translatable biomarker for innate immune response to disease and injury. It has long been a target of interest for non-invasive in vivo PET (positron emission tomography) imaging of both microglial activation in the central nervous system (CNS) and macrophage activity in the periphery.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation