&lt;i&gt;Fusobacterium necrophorum&lt;/i&gt; Endocarditis with Liver Abscesses: A Case Report and Review of the Literature

Sato, Kosei; Matsubara, Taku; Imai, Shoichi; Hatada, Katsuharu; Mitsuma, Wataru; Kawasaki, Satoshi; Hama, Isamu; Kamura, Takeshi

doi:10.2169/internalmedicine.6348-20

Cited by 9 publications

(6 citation statements)

References 23 publications

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“…Blood culture is important diagnostic evidence. However, it is difficult to make a timely and accurate diagnosis of F. necrophorum infection by blood culture because of its obligate anaerobic condition, harsh culture conditions, long culture time (mean 6-8 days), and low positive rate (Riordan, 2007;Sacco et al, 2019;Sato et al, 2021). Through a review of the literature in Table 1, we found that only 12 cases of F. necrophorum infection have been successfully confirmed in children.…”

Section: Discussionmentioning

confidence: 97%

Case report: Metagenomics next-generation sequencing in the diagnosis of septic shock due to Fusobacterium necrophorum in a 6-year-old child

Zhang,

Liu,

Guan

et al. 2024

Front. Cell. Infect. Microbiol.

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Fusobacterium necrophorum (F. necrophorum) infection is rare in pediatrics. In addition, the detection time of F. necrophorum by blood culture is long, and the positive rate is low. Infection with F. necrophorum bacilli usually follows rapid disease progression, resulting in high mortality. In previous reports of F. necrophorum-related cases, the most dangerous moment of the disease occurred after the appearance of Lemierre’s syndrome. We report an atypical case of a 6-year-old female patient who developed septic shock within 24 h of admission due to F. necrophorum infection in the absence of Lemierre’s syndrome. F. necrophorum was identified in a blood sample by metagenomics next-generation sequencing (mNGS) but not by standard blood culture. The patient was finally cured and discharged after receiving timely and effective targeted anti-infection treatment. In the present case study, it was observed that the heightened virulence and invasiveness of F. necrophorum contribute significantly to its role as a primary pathogen in pediatric septic shock. This can precipitate hemodynamic instability and multiple organ failure, even in the absence of Lemierre’s syndrome. The use of mNGS can deeply and rapidly identify infectious pathogens, guide the use of targeted antibiotics, and greatly improve the survival rate of patients.

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Section: Discussionmentioning

confidence: 97%

Case report: Metagenomics next-generation sequencing in the diagnosis of septic shock due to Fusobacterium necrophorum in a 6-year-old child

Zhang,

Liu,

Guan

et al. 2024

Front. Cell. Infect. Microbiol.

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“…F. necrophorum is a critical pathogen isolated from oral cavities, gastrointestinal tracts, and genitourinary tracts of animals and humans ( Tadepalli et al., 2009 ; Sato et al., 2021 ). It is frequently associated with necrotic infections in animals, such as calf diphtheria, foot rot, and liver abscesses ( Langworth, 1977 ).…”

Section: Discussionmentioning

confidence: 99%

Fusobacterium necrophorum Promotes Apoptosis and Inflammatory Cytokine Production Through the Activation of NF-κB and Death Receptor Signaling Pathways

Wang

Zhao

et al. 2022

Front. Cell. Infect. Microbiol.

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Fusobacterium necrophorum can cause liver abscess, foot rot in ruminants, and Lemire syndrome in humans, Also, its virulence factors can induce the apoptosis of macrophages and neutrophils. However, the detailed mechanism has not been fully clarified. This study investigated the mechanisms of apoptosis and inflammatory factor production in F. necrophorum–induced neutrophils and macrophages (RAW246.7). After infection of macrophages with F. necrophorum, 5-ethynyl-2’-deoxyuridine labeling assays indicated that F. necrophorum inhibited macrophage proliferation in a time- and dose-dependent manner. Hoechst staining and DNA ladder assays showed significant condensation of the nucleus and fragmentation of genomic DNA in F. necrophorum–infected macrophages, Annexin V (FITC) and propidium iodide (PI) assay confirmed the emergence of apoptosis in the macrophages and sheep neutrophils with F. necrophorum compared with the control. The group with significant apoptosis was subjected to RNA sequencing (RNA-Seq), and the sequencing results revealed 2581 up– and 2907 downregulated genes. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis of the differentially expressed genes showed that F. necrophorum drove apoptosis and production of inflammatory factors by activating genes related to the Nuclear Factor-κB (NF-κB) and death receptor pathways. Meanwhile, quantitative reverse transcription PCR and Western blot validation results were consistent with the results of transcriptome sequencing analysis. In conclusion, F. necrophorum induced apoptosis and production of pro-inflammatory factors through the NF-κB and death receptor signaling pathway, providing a theoretical basis for further mechanistic studies on the prevention and control of F. necrophorum disease treatment.

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“…We found 14 case reports with different bacteria in both immunocompromised and immunocompetent patients. Kaho Sato et al 16 reported a case of a 51-year-old previously healthy woman presenting with a liver abscess and mitral valve endocarditis. Both of her blood cultures grew Fusobacterium necrophorum, and she was treated with ceftriaxone and metronidazole.…”

Section: Case Methodsmentioning

confidence: 99%

Left‐sided infective endocarditis presenting with pulmonary involvement and liver abscess: A case report

Basiri,

Shazdehahmadi,

Boskabadi

2024

Clinical Case Reports

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Key Clinical MessageInfective endocarditis is an important differential diagnosis in patients with persistent fever and chills not responding to antibiotics and involvement of multiple organs. It can present without any specific signs such as valvular murmurs and no growth on blood cultures. Therefore, considering an echocardiography can be crucial and helpful in establishing the diagnosis.AbstractInfective endocarditis (IE), a rare disease with high mortality, arises from microbial infection affecting the heart valves and endocardium. It exhibits diverse symptoms and can involve various organs, including the brain, lungs, spleen, and liver. Diagnosis is often intricate due to its polymorphic nature, and negative blood cultures can add complexity to the diagnostic process. In this report, we present an unusual case of IE in a 53‐year‐old male farmer with multi‐organ involvement, including liver abscesses and pulmonary infiltration with cavities. Echocardiography showed a nodular mass attached to his bicuspid aortic valve, thus, playing a crucial role in confirming the diagnosis. This atypical manifestation highlights the necessity for increased clinical vigilance and further research to improve diagnostic approaches for uncommon IE cases.

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<i>Fusobacterium necrophorum</i> Endocarditis with Liver Abscesses: A Case Report and Review of the Literature

Cited by 9 publications

References 23 publications

Case report: Metagenomics next-generation sequencing in the diagnosis of septic shock due to Fusobacterium necrophorum in a 6-year-old child

Case report: Metagenomics next-generation sequencing in the diagnosis of septic shock due to Fusobacterium necrophorum in a 6-year-old child

Fusobacterium necrophorum Promotes Apoptosis and Inflammatory Cytokine Production Through the Activation of NF-κB and Death Receptor Signaling Pathways

Left‐sided infective endocarditis presenting with pulmonary involvement and liver abscess: A case report

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