Effect of synbiotics and probiotics supplementation on autoimmune diseases: A systematic review and meta-analysis of clinical trials

Askari, Gholamreza; Ghavami, Abed; Shahdadian, Farnaz; Moravejolahkami, Amir Reza

doi:10.1016/j.clnu.2021.02.015

Cited by 20 publications

(9 citation statements)

References 53 publications

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“…Synbiotics are nutritional supplements with immunomodulatory properties 36 that have been shown to be useful in the management of autoimmune inflammatory disorders. 37 The present randomized double-masked placebo-controlled trial was the first investigation assessing the effects of synbiotic supplementation on Tregs in patients with axSpA. Our research demonstrated that synbiotic supplementation led to a significant elevation in Treg cells' proportion in comparison with the baseline and placebo.…”

Section: Discussionmentioning

confidence: 57%

Effects of synbiotic supplementation on regulatory T cells’ response in patients with axial spondyloarthritis: a randomized double-masked placebo-controlled trial

et al. 2022

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Section: Discussionmentioning

confidence: 57%

Effects of synbiotic supplementation on regulatory T cells’ response in patients with axial spondyloarthritis: a randomized double-masked placebo-controlled trial

et al. 2022

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“…Coomes et al [79] in a meta-analysis concluded that inhibition of IL-6 may be a novel target for therapeutic goals in patients with COVID-19. The current state of knowledge on the immunomodulatory effects of probiotics has recently advanced [80].…”

Section: Discussionmentioning

confidence: 99%

The efficacy of probiotics on virus titres and antibody production in virus diseases: A systematic review on recent evidence for COVID-19 treatment

Mirashrafi

Moravejolahkami

Zehi

et al. 2021

Clinical Nutrition ESPEN

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Background & Aims There are some studies indicating the effects of probiotic-containing foods or supplements on viral diseases. We aimed to conduct a rapid review of probiotics with specific emphasis on their potential for early administration in patients at greater risk of SARS-CoV-2 infection. Methods We searched on PubMed, EMBASE, Google Scholar, Science Direct, Scopus and Web of Science up to February 2021 to identify interventional and observational studies documenting the effects of probiotics strains on interleukins, virus titers, and antibody production with a focus on probiotic-containing foods (PROSPERO Registration ID. CRD42020181453). Results From a total of 163 records, 21 studies were classified into three domains based on the efficacy of probiotics on 1) the level of interleukins (n=7), 2) virus titers (n=2), and 3) interferon (IFN) and antibody production (n=12). The suppuration of pro-inflammatory interleukins and type I INF production seemed to be the main anti-viral effect of probiotics. Nine studies also indicated the beneficial effects of probiotics and fermented foods on viral diseases. Conclusion Based on evidence, some probiotic strains may be useful in viral infections; randomized trials are needed to confirm these findings.

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“…The beneficial effects of probiotics in autoimmune- and immune-mediated diseases appear to be connected to a decline in pro-inflammatory indicators, such as the production of IL-6 and CRP or the activation of Th1 and Th17 cells [ 163 ]. Additionally, recent studies imply that an anti-inflammatory effect of probiotics may result from their ability to improve gut permeability [ 164 ].…”

Section: Future Perspectivesmentioning

confidence: 99%

Bacterial Metabolites: A Link between Gut Microbiota and Dermatological Diseases

Stec

Sikora

Maciejewska

et al. 2023

IJMS

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Dysbiosis has been identified in many dermatological conditions (e.g., psoriasis, atopic dermatitis, systemic lupus erythematosus). One of the ways by which the microbiota affect homeostasis is through microbiota-derived molecules (metabolites). There are three main groups of metabolites: short-chain fatty acids (SCFAs), tryptophan metabolites, and amine derivatives including trimethylamine N-oxide (TMAO). Each group has its own uptake and specific receptors through which these metabolites can exert their systemic function. This review provides up-to-date knowledge about the impact that these groups of gut microbiota metabolites may have in dermatological conditions. Special attention is paid to the effect of microbial metabolites on the immune system, including changes in the profile of the immune cells and cytokine disbalance, which are characteristic of several dermatological diseases, especially psoriasis and atopic dermatitis. Targeting the production of microbiota metabolites may serve as a novel therapeutic approach in several immune-mediated dermatological diseases.

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Effect of synbiotics and probiotics supplementation on autoimmune diseases: A systematic review and meta-analysis of clinical trials

Cited by 20 publications

References 53 publications

Effects of synbiotic supplementation on regulatory T cells’ response in patients with axial spondyloarthritis: a randomized double-masked placebo-controlled trial

Effects of synbiotic supplementation on regulatory T cells’ response in patients with axial spondyloarthritis: a randomized double-masked placebo-controlled trial

The efficacy of probiotics on virus titres and antibody production in virus diseases: A systematic review on recent evidence for COVID-19 treatment

Bacterial Metabolites: A Link between Gut Microbiota and Dermatological Diseases

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