Neurokinin-1 receptor signaling induces a pro-inflammatory transcriptomic profile in CD16+ monocytes

Pappa, Vasiliki; Spitsin, Sergei; Gaskill, Peter J.; Douglas, Steven D.

doi:10.1016/j.jneuroim.2021.577524

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…In addition, several NIMH-supported studies have examined mechanisms that regulate HIV-infected monocyte trafficking into the CNS. Pappa et al 16 studied regulation of monocyte trafficking and showed that Neurokinin-1 receptor signaling can be immunomodulatory and it can lead to preferential transmigration of CD14+CD16+ monocytes across the BBB, potentially leading to the development of inflammatory CNS comorbidities. These may be mediated by increases in the expression of NF-κB and components of the NLRP3 inflammasome pathway.…”

Section: Role Of Macrophages In Hiv Infection Replication and Seeding...mentioning

confidence: 99%

Role of macrophages in HIV pathogenesis and cure: NIH perspectives

Joseph

Daley

Lawrence

et al. 2022

Journal of Leukocyte Biology

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Macrophages play a significant role in HIV infection and contribute to pathogenesis of comorbidities as well as establishment of the viral reservoir in people living with HIV. While CD4+ T cells are considered the main targets of HIV infection, infected macrophages resist the cytopathic effects of infection, contributing to the persistent HIV reservoir. Furthermore, activated macrophages drive inflammation and contribute to the development of comorbidities, including HIV‐associated CNS dysfunction. Better understanding the role of macrophages in HIV infection, persistence, and comorbidities can lead to development of innovative therapeutic strategies to address HIV‐related outcomes in people living with HIV. In October 2021, the National Institute of Mental Health and the Ragon Institute of MGH, MIT, and Harvard conducted a virtual meeting on role of macrophages in HIV infection, pathogenesis, and cure. This review article captures the key highlights from this meeting and provides an overview of interests and activities of various NIH institutes involved in supporting research on macrophages and HIV.

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Section: Role Of Macrophages In Hiv Infection Replication and Seeding...mentioning

confidence: 99%

Role of macrophages in HIV pathogenesis and cure: NIH perspectives

Joseph

Daley

Lawrence

et al. 2022

Journal of Leukocyte Biology

View full text Add to dashboard Cite

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The diversity of neuroimmune circuits controlling lung inflammation

Cremin

Schreiber

Murray

et al. 2023

American Journal of Physiology-Lung Cellular and Molecular Phys

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It is becoming increasingly appreciated that the nervous and immune systems communicate bidirectionally to regulate immunological outcomes in a variety of organs including the lung. Activation of neuronal signaling can be induced by inflammation, tissue damage, or pathogens to evoke or reduce immune cell activation in what has been termed a neuro-immune reflex. In the periphery, these reflexes include the cholinergic anti-inflammatory pathway, sympathetic reflex, and sensory nociceptor-immune cell pathways. Continual advances in neuroimmunology in peripheral organ systems have fueled small-scale clinical trials that have yielded encouraging results for a range of immunopathologies such as rheumatoid arthritis. Despite these successes, several limitations should give clinical investigators pause in the application of neural stimulation as a therapeutic for lung inflammation, especially if inflammation arises from a novel pathogen. In this review, the general mechanisms of each reflex, the evidence for these circuits in the control of lung inflammation, and the key knowledge gaps in our understanding of these neuroimmune circuits will be discussed. These limitations can be overcome not only through better understanding of neuroanatomy but also through a systematic evaluation of stimulation parameters using immune activation in lung tissues as primary readouts. Our rapidly evolving understanding of the nervous and immune systems highlights the importance of bidirectional communication between these cells in health and disease. This integrative approach has tremendous potential in the development of targeted therapeutics, if specific challenges can be overcome.

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Neurokinin-1 receptor signaling induces a pro-inflammatory transcriptomic profile in CD16+ monocytes

Cited by 2 publications

References 24 publications

Role of macrophages in HIV pathogenesis and cure: NIH perspectives

Role of macrophages in HIV pathogenesis and cure: NIH perspectives

The diversity of neuroimmune circuits controlling lung inflammation

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