Prognosis of hemodialysis patients undergoing surgery for gastric cancer: Results of a multicenter retrospective study

Sugawara, Katsuhiko; Yamashita, Hiroharu; Yajima, Satoshi; Oshima, Yoshiteru; Mitsumori, Norio; Fujisaki, Muneharu; Yamazaki, Kaoru; Otsuka, Koji; Futawatari, Nobue; Watanabe, Ryohei; Satodate, Hitoshi; Yoshimoto, Yutaro; Nagaoka, Sakae; Tokuyama, Jo; Sasaki, Shin; Seto, Yasuyuki; Shimada, Hideaki

doi:10.1016/j.surg.2021.01.014

Cited by 3 publications

(2 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the past 20 years had been characterized by the expansion of clarifying the molecular mechanism of GC and an advance in diagnostic and therapeutic methods for managing GC patients, the survival outcomes have remained poor (Liu et al, 2020b;Sugawara et al, 2021). Immunotherapy has emerged as a new therapeutic treatment for several cancer types, and the utilization of gene expression signatures to determine the immunotherapeutic outcomes is yet to be reported.…”

Section: Discussionmentioning

confidence: 99%

Development of a Novel Immune-Related Gene Signature to Predict Prognosis and Immunotherapeutic Efficiency in Gastric Cancer

Fang

et al. 2022

Front. Genet.

View full text Add to dashboard Cite

Background: Gastric cancer (GC) is the fifth most common malignancy and the third leading cause of tumor-related deaths globally. Herein, we attempted to build a novel immune-related gene (IRG) signature that could predict the prognosis and immunotherapeutic efficiency for GC patients.Methods: The mRNA transcription data and corresponding clinical data of GC were downloaded from The Cancer Genome Atlas (TCGA) database as the training group and the GSE84437 data set as the testing cohort, followed by acquisition of IRGs from the InnateDB resource and ImmPort database. Using the univariate Cox regression analysis, an IRG signature was developed. Several immunogenomic analyses were performed to illustrate the associations between the immune risk score and tumor mutational burden, immune cell infiltrations, function of immune infiltration, clinical characteristics, immune subtype, and immunotherapeutic response.Results: The analysis of 343 GC samples and 30 normal samples from the TCGA database gave rise to 8,713 differentially expressed genes (DEGs) and 513 differentially expressed immune-related genes (DEIRGs) were extracted. The novel IRG signature contained eight DEIRGs (FABP4, PI15, RNASE2, CGB5, INHBE, RLN2, DUSP1, and CD36) and was found to serve as an independent predictive and prognostic factor for GC. Then, the GC patients were separated into the high- and low-risk groups based on the median risk score, wherein the low-risk group presented a better prognosis and was more sensitive to immunotherapy than did the high-risk group. According to the time-dependent ROC curves and AUCs, the immunotherapeutic value of the signature was better than the Tumor Immune Dysfunction and Exclusion (TIDE) and T-cell inflammatory signature (TIS) scores. In addition, the AUCs of the risk score for predicting 1-, 2-, and 3-year OS were 0.675, 0.682, and 0.710, respectively, which indicated that the signature had great predictive power.Conclusion: This study presents a novel IRG signature based on the tumor immune microenvironment, which could improve the prediction of the prognosis and immunotherapeutic efficiency for GC patients. The powerful signature may serve as novel biomarkers and provide therapeutic targets for precision oncology in clinical practice.

show abstract

Section: Discussionmentioning

confidence: 99%

Development of a Novel Immune-Related Gene Signature to Predict Prognosis and Immunotherapeutic Efficiency in Gastric Cancer

Fang

et al. 2022

Front. Genet.

View full text Add to dashboard Cite

show abstract

“…Although the past 20 years have been characterized by the expansion of clarifying the molecular mechanism of GC and an advance in diagnostic and therapeutic methods for managing GC patients, the survival outcomes remained poor ( Liu et al, 2020 ; Sugawara et al, 2021 ). Hence, searching for specific molecular biomarkers for the tumorigenesis and pathogenesis of GC had important significance in the diagnosis and treatment of patients.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis of the Expression and Prognosis for ITGBs: Identification of ITGB5 as a Biomarker of Poor Prognosis and Correlated with Immune Infiltrates in Gastric Cancer

Liu

Fang

et al. 2022

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Background: Integrin β superfamily members (ITGBs) are documented to play important roles in various biological processes, and accumulating evidence suggests that ITGBs are associated with carcinogenic effects in several malignancies. Gastric cancer (GC) is a complicated and highly heterogeneous disease; however, the expression and prognostic values of eight ITGBs and potential mechanism in GC remain largely unclear.Methods: The expression and prognostic significance of ITGBs in GC were systematically analyzed through Gene Expression Profiling Interactive Analysis, Human Protein Atlas, Kaplan–Meier Plotter, and cBioPortal databases. Then, the mRNA transcription data and corresponding clinical data of GC were downloaded from the Gene Expression Omnibus database as a testing cohort, and differentially expressed and prognostic genes were identified. The correlation between ITGB5 expression and overall survival and various clinical parameters were found by using univariate/multivariable Cox regression and Kaplan–Meier survival analysis. Additionally, differential analysis of gene expression profiles in low- and high-ITGB5 expression groups and pathway enrichment analysis was performed. Finally, the correlation of ITGB5 expression with immune infiltrates in GC was clarified.Results: Compared with adjacent normal tissue, the results reveal that the mRNA levels of ITGB1-2 and ITGB4-8 are significantly higher in GC, and immunohistochemistry results show the consistency between RNA and protein expression levels. Cox regression and Kaplan–Meier survival analysis indicate that high ITGB5 expression contributes to a poor prognosis and could be an independent prognostic factor in GC patients. Besides this, gene functional enrichment analysis indicates that ITGB5 expression is significantly associated with extracellular matrix organization, cell-substrate adhesion, and ossification. The KEGG pathway analysis of ITGB5 shows a close association between ITGB5 and focal adhesion, ECM-receptor interaction, phagosome, and PI3K-Akt signaling pathway. Last, the infiltrating level of CD4+ T cells, macrophages, and dendritic cells are positively related to the expression of ITGB5, especially macrophages, and lower levels of macrophages predict a better prognosis in GC in our study.Conclusion: Our findings investigate that ITGB5 may function as a valid biomarker of prognosis, and high expression of ITGB5 predicts poor prognosis for patients with GC. Besides this, it might be a potential target of precision therapy against GC.

show abstract

Feasible living donor liver transplantation for patients on chronic hemodialysis: a multicenter study in East Asian countries

Furukawa,

Lee,

Shimata

et al. 2023

Surg Today

View full text Add to dashboard Cite

Prognosis of hemodialysis patients undergoing surgery for gastric cancer: Results of a multicenter retrospective study

Cited by 3 publications

References 40 publications

Development of a Novel Immune-Related Gene Signature to Predict Prognosis and Immunotherapeutic Efficiency in Gastric Cancer

Development of a Novel Immune-Related Gene Signature to Predict Prognosis and Immunotherapeutic Efficiency in Gastric Cancer

Comprehensive Analysis of the Expression and Prognosis for ITGBs: Identification of ITGB5 as a Biomarker of Poor Prognosis and Correlated with Immune Infiltrates in Gastric Cancer

Feasible living donor liver transplantation for patients on chronic hemodialysis: a multicenter study in East Asian countries

Contact Info

Product

Resources

About