Can vitamin E supplementation affect obesity indices? A systematic review and meta-analysis of twenty-four randomized controlled trials

Emami, Mohammad Reza; Jamshidi, Sanaz; Zarezadeh, Meysam; Khorshidi, Masoud; Olang, Beheshteh; Hezaveh, Zohreh Sajadi; Sohouli, Mohammad Hassan; Aryaeian, Naheed

doi:10.1016/j.clnu.2021.02.002

Cited by 11 publications

(11 citation statements)

References 47 publications

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“…In mice treated with low or high vitamin E for 34 days (DL‐α‐tocopherol, 0.06 mg/20 g and 0.18 mg/20 g BW per day, respectively), the low dose increased spleen and BW, possibly involving a change in the composition of gut microbiota (ratio of Firmicutes to Bacteroidetes ) 289 . Interestingly, as revealed by meta‐analysis vitamin E supplementation did not significantly affect weight and BMI except in people with normal BMI (18.5–24.9) where it increased it 258 …”

Section: Bioactive Dietary Components and Their Anti‐obesity Effectsmentioning

confidence: 90%

“…While sharing a similar cellular uptake mechanism as fatty acids and other hydrophobic molecules, vitamin E (α‐tocopherol) is selectively incorporated into plasma lipoproteins by the alpha‐tocopherol transfer protein when reaching the liver leading to an up to 50‐fold enrichment in plasma (average 23 μM) 257 . Vitamin E is not known for having regulatory effects on BW, 258 but as a lipid‐soluble antioxidant and signaling molecule, it modulates a number of cellular events relevant for fatty acids uptake, metabolism, accumulation, storage and release. It prevents the formation of lipid peroxidation products derived from unsaturated fatty acids (monounsaturated fatty acids, MUFA and PUFA), that mediate lipid‐mediated stress, inflammatory signaling or induced cell death (lipotoxicity) relevant for the adverse pathology of excess fat in obesity and metabolic disease 211–213 …”

Section: Bioactive Dietary Components and Their Anti‐obesity Effectsmentioning

confidence: 99%

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Bioactive dietary components—Anti‐obesity effects related to energy metabolism and inflammation

et al. 2022

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Obesity is the result of the long-term energy imbalance between the excess calories consumed and the few calories expended. Reducing the intake of energy dense foods (fats, sugars), and strategies such as fasting and caloric restriction can promote body weight loss. Not only energy in terms of calories, but also the specific composition of the diet can affect the way the food is absorbed and how its energy is stored, used or dissipated. Recent research has shown that bioactive components of food, such as polyphenols and vitamins, can influence obesity and its pathologic complications such as insulin resistance, inflammation and

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Section: Bioactive Dietary Components and Their Anti‐obesity Effectsmentioning

confidence: 90%

Section: Bioactive Dietary Components and Their Anti‐obesity Effectsmentioning

confidence: 99%

Bioactive dietary components—Anti‐obesity effects related to energy metabolism and inflammation

et al. 2022

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“…[21][22][23] A recent meta-analysis concluded that vitamin E supplementation had no effects on waist circumference (WC) and BMI. 24 A systematic review and meta-analysis reported that higher TAC had a significant association with lower WC while had no significant association with BMI in adult population. 25 Dietary antioxidant index (DAI) as a validated nutritional tool has been recently considered to evaluate the antioxidant capacity of diets and is calculated based on the intake of major dietary antioxidants including vitamin A, vitamin C, vitamin E, selenium, manganese, and zinc.…”

Section: Introductionmentioning

confidence: 99%

“…However, contradictory results were reported on the association of obesity and dietary antioxidants, especially in adolescents 21–23 . A recent meta‐analysis concluded that vitamin E supplementation had no effects on waist circumference (WC) and BMI 24 . A systematic review and meta‐analysis reported that higher TAC had a significant association with lower WC while had no significant association with BMI in adult population 25 …”

Section: Introductionmentioning

confidence: 99%

Association of dietary antioxidant index with body mass index in adolescents

Aminnejad

Roumi

Ardekanizadeh

et al. 2022

Obesity Science & Practice

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Background Dietary antioxidants may decrease body fat through reduction of oxidative stress. This study aimed to examine the association between dietary antioxidant index (DAI) and body mass index (BMI) in adolescent boys. Methods In this cross‐sectional study, 593 adolescent boys aged 12–16 years were randomly selected and were divided into two groups of overweight and non‐overweight individuals. Data on physical activity and anthropometric measurements were collected. Dietary intake was assessed using 168‐item semi quantitative food frequency questionnaire and the DAI score was calculated to measure the antioxidant capacity of the diet. Results The overweight adolescents had higher intake of energy (2490.55 ± 632.49 vs. 2354.33 ± 632.64 kcal/d, p = 0.01), carbohydrate (290.21 ± 71.41 vs. 272.93 ± 79.22 g/d, p = 0.01), fat (111.51 ± 40.76 vs. 104.51 ± 35.56 g/d, p = 0.04), calcium (811.70 ± 283.70 vs. 741.06 ± 251.17 g/d, p = 0.003), and vitamin D (1.41 ± 1.17 vs. 1.18 ± 1.19 μg/d, p = 0.031) in comparison with normal weight adolescents. The DAI had an inverse association with BMI after adjustment for age and caloric intake (OR: 0.85, 95% CI: 0.76–0.96, p = 0.009). Additional adjustment for dietary intake of vitamin A, vitamin E, vitamin C, zinc, manganese, and selenium did not change the results. Conclusion The results of the study showed that following a diet rich in antioxidants may be effective in preventing obesity in adolescent boys. Further longitudinal studies are needed to confirm these finding and to determine the underlying mechanisms.

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“…In addition, clinical trials have reported contradictory results regarding the effect of vitamin E supplementation on weight status. Some studies reported an increase [18], some reported a decrease [19], and some reported no significant changes in body mass index (BMI) and weight following vitamin E supplementation [20]. Therefore, the effects of antioxidants on improving metabolic disorders in obese patients remain to be clarified.…”

Section: Introductionmentioning

confidence: 99%

Effects of Antioxidant Supplementation on Metabolic Disorders in Obese Patients from Randomized Clinical Controls: A Meta-Analysis and Systematic Review

Wang

Liao

Wang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Purpose. This systematic review and meta-analysis aim at elucidating the heterogeneity in beneficial effects of antioxidant supplementation in obese adults by exploring the differential effects of antioxidant supplementation on basic indicators of obesity, lipid metabolism, systemic antioxidant capacity, inflammatory biomarkers, and liver function. Methods. The inclusion criteria specified randomized controlled trials with antioxidant intervention for adults ( mean body mass index BMI > 30 ), from inception to Aug. 8, 2021, in the PubMed, Embase, The Cochrane Library, Web of Science, and Scopus databases. Meta-analysis and publication bias were performed using RevMan 5.4 software. Stata16 software was used to detect publication bias with Egger’s and Begg’s methods being mainly used. The data of basic indicators of obesity, lipid metabolism index, oxidative stress index, inflammatory biomarkers, and liver function index were collected to analyze the beneficial effects of antioxidant supplementation in obese patients. Results. A total of 30 studies were included in this study with a sample of 845 obese patients from the antioxidant supplementation group and 766 obese patients from the placebo control group. The meta-analysis showed that obese patients with antioxidant supplementation had lower BMI ( mean difference MD : − 0.44 [ 95 % confidence interval CI : − 0.84 , − 0.04 ], p = 0.03 ), waist circumference ( MD : − 0.78 95 % CI : − 1.45 , − 0.11 , p = 0.02 ), fasting blood glucose (FBG) level ( standardized mean difference SMD : − 4.92 95 % CI : − 6.87 , − 2.98 , p < 0.001 ) and homeostasis model assessment of insulin resistance ( MD : − 0.45 95 % CI : − 0.61 , − 0.3 , p < 0.001 ) when compared to the placebo group. Obese patients on antioxidant supplementation had lower levels of total cholesterol ( SMD : − 0.43 95 % CI : − 0.84 , − 0.02 , p = 0.04 ), triglycerides ( SMD : − 0.17 95 % CI : − 0.31 , − 0.04 , p = 0.01 ), low-density lipoprotein ( SMD : − 0.15 95 % CI : − 0.29 , − 0.01 , p = 0.03 ), malondialdehyde ( SMD : − 1.67 95 % CI : − 2.69 , − 0.65 , p = 0.001 ), and tumor necrosis factor-alpha ( SMD : − 0.29 95 % CI : − 0.56 , − 0.02 , p = 0.03 ), respectively, when compared to the placebo group. In addition, obese patients with antioxidant supplementation had higher levels of high-density lipoprotein ( SMD : 0.25 95 % CI : 0.03 , 0.46 , p = 0.03 ) and superoxide dismutase ( SMD : 1.09 95 % CI : 0.52 , 1.65 , p < 0.001 ) when compared to the placebo group. Antioxidant supplementation had no effects on other analyzed parameters including waist–hip ratio, leptin, fat mass, interleukin-6, C-reactive protein, alanine transaminase, and aspartate transaminase in obese patients. Conclusion. The meta-analysis results indicated that antioxidant supplementation exerted potential beneficial effects in obese patients by regulating FBG, oxidative stress, and inflammation, whilst more high-quality studies are required to confirm these effects. The present study may provide important insights for the treatment of clinical obesity and obesity-associated complications.

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Can vitamin E supplementation affect obesity indices? A systematic review and meta-analysis of twenty-four randomized controlled trials

Cited by 11 publications

References 47 publications

Bioactive dietary components—Anti‐obesity effects related to energy metabolism and inflammation

Bioactive dietary components—Anti‐obesity effects related to energy metabolism and inflammation

Association of dietary antioxidant index with body mass index in adolescents

Effects of Antioxidant Supplementation on Metabolic Disorders in Obese Patients from Randomized Clinical Controls: A Meta-Analysis and Systematic Review

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