Chemical characterization and in vitro anthelmintic activity of Citrus bergamia Risso and Citrus X paradisii Macfad essential oil against Haemonchus contortus Kirby isolate

Garbin, Vivien Patricia; Munguía, Beatriz; Saldaña, Jenny; Deschamps, Cícero; Cipriano, Roger Raupp; Molento, Marcelo Beltrão

doi:10.1016/j.actatropica.2021.105869

Cited by 9 publications

(6 citation statements)

References 49 publications

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“…There are many studies in the literature on the anthelmintic activity of various plant extracts (Garbin et al, 2021;Lima et al, 2021). Ethnobotanical studies have shown that Consolida species are commonly used as anthelmintic plants in some countries such as Turkey and China (Yin et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Anti-helminthic Activity of Consolida orientalis (Gay) Schröd. on Caenorhabditis elegans Nematodes and Determination of Possible Active Ingredients

Özpınar

2021

Turkish JAF Sci.Tech.

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Helminthiasis is an important parasitic disease, many of which are zoonotic, particularly common in developing countries and, in countries with hot and humid climates. Intestinal parasites can cause significant manifestations at all levels of the gastrointestinal tract, as well as anemia and growth retardation. This study aims to demonstrate the anti-helminthic effect of Consolida orientalis on Caenorhabditis elegans, which is a helminth model, and introduce new chemotherapeutic candidate substances with anti-helminthic effect to the literature by identifying possible active ingredients with GC-MS analysis. In our study, flower, leaf, stem and aerial part plant extracts of Consolida orientalis were used at 40 mg/mL, 20 mg/mL, 10 mg/mL, 5 mg/mL, 2.5 mg/mL, 1.25 mg/mL concentrations. In addition, possible active ingredients found in plant extracts were determined by GC-MS analysis. As a result of the study, it was determined that the aerial part, leaf and stem extract of the first four concentrates (40 mg/mL, 20 mg/mL, 10 mg/mL, 5 mg/mL) of Consolida orientalis were more effective than pyrantel pamoate at a concentration of 5 mg/mL. According to our study findings, chemotherapeutics such as Dihidrocarvone and 2(3H)-Benzoxazolone with new antihelmintic-antiparasitic activity are thought to contribute to further research.

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Section: Discussionmentioning

confidence: 99%

Anti-helminthic Activity of Consolida orientalis (Gay) Schröd. on Caenorhabditis elegans Nematodes and Determination of Possible Active Ingredients

Özpınar

2021

Turkish JAF Sci.Tech.

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“…This examination relies on the absence of movement (paralysis or death) of larvae or adult worms, the inability of the eggs to hatch, or the larvae to continue with their life cycle [ 133 ]. These observations indicate the effectiveness of a given extract or compound in inhibiting parasitic growth through various mechanisms, including alterations in metabolism [ 134 ].…”

Section: Antiparasitic Activitymentioning

confidence: 99%

Current Landscape of Methods to Evaluate Antimicrobial Activity of Natural Extracts

et al. 2023

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Natural extracts have been and continue to be used to treat a wide range of medical conditions, from infectious diseases to cancer, based on their convenience and therapeutic potential. Natural products derived from microbes, plants, and animals offer a broad variety of molecules and chemical compounds. Natural products are not only one of the most important sources for innovative drug development for animal and human health, but they are also an inspiration for synthetic biology and chemistry scientists towards the discovery of new bioactive compounds and pharmaceuticals. This is particularly relevant in the current context, where antimicrobial resistance has risen as a global health problem. Thus, efforts are being directed toward studying natural compounds’ chemical composition and bioactive potential to generate drugs with better efficacy and lower toxicity than existing molecules. Currently, a wide range of methodologies are used to analyze the in vitro activity of natural extracts to determine their suitability as antimicrobial agents. Despite traditional technologies being the most employed, technological advances have contributed to the implementation of methods able to circumvent issues related to analysis capacity, time, sensitivity, and reproducibility. This review produces an updated analysis of the conventional and current methods to evaluate the antimicrobial activity of natural compounds.

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“…Alternativas in vitro e bioensaios são mais econômicos e foram desenvolvidos para a detecção de resistência e testes de prospecção para novos produtos, 68,69 incluindo fitoterápicos . Dentre eles, TIML e o teste de desenvolvimento larval (TDL) e suas modificações, estão sendo refinadas para a detecção de resistência para os principais princípios ativos, entre eles: benzi-67 midazóis, levamisol e lactonas macrocíclicas .…”

Section: Anti-helmínticos Dias De Tratamentounclassified

Exames coproparasitológicos em ruminantes uma abordagem espaço-temporal

Molento¹,

Pontarolo²,

Pires³

et al. 2021

Rev. Bras. Buiatria

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Chemical characterization and in vitro anthelmintic activity of Citrus bergamia Risso and Citrus X paradisii Macfad essential oil against Haemonchus contortus Kirby isolate

Cited by 9 publications

References 49 publications

Anti-helminthic Activity of Consolida orientalis (Gay) Schröd. on Caenorhabditis elegans Nematodes and Determination of Possible Active Ingredients

Anti-helminthic Activity of Consolida orientalis (Gay) Schröd. on Caenorhabditis elegans Nematodes and Determination of Possible Active Ingredients

Current Landscape of Methods to Evaluate Antimicrobial Activity of Natural Extracts

Exames coproparasitológicos em ruminantes uma abordagem espaço-temporal

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