Mannose-binding lectin and risk of infections in type 2 diabetes: A Danish cohort study

Gedebjerg, Anne; Thomsen, Reimar Wernich; Kjærgaard, Alisa D; Steffensen, Rudi; Nielsen, Jens Steen; Rungby, Jørgen; Friborg, Søren; Brandslund, Ivan; Thiel, Steffen; Beck‐Nielsen, Henning; Sørensen, Henrik Toft; Hansen, Troels Krarup; Bjerre, Mette

doi:10.1016/j.jdiacomp.2021.107873

Cited by 1 publication

(2 citation statements)

References 45 publications

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“…Intra‐ and inter‐plate coefficients of variation were 5% and 14.4% for TNF‐α, and 6.1% and 12.3% for IL‐6. We measured serum hsCRP (mg/L) with an enzyme‐linked immunosorbent assay technique using an in‐house time‐resolved immuno‐fluorometric assay, as previously described 18,19 . Intra‐ and inter‐assay coefficients of variation were <5% and <6%, respectively.…”

Section: Methodsmentioning

confidence: 99%

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Low‐grade inflammation in persons with recently diagnosed type 2 diabetes: The role of abdominal adiposity and putative mediators

Domazet,

Olesen,

Stidsen

et al. 2024

Diabetes Obesity Metabolism

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AimsTo determine the magnitude of the association between abdominal adiposity and low‐grade inflammation in persons with recently diagnosed type 2 diabetes (T2D) and to determine to what extent this association is mediated by low physical activity level, hyperinsulinaemia, hyperglycaemia, dyslipidaemia, hypertension, and comorbidities.Materials and MethodsWe measured waist circumference, clinical characteristics, and inflammatory markers i.e. tumour necrosis factor‐alpha (TNF‐α), interleukin‐6 (IL‐6), and high‐sensitivity C‐reactive protein (hsCRP), in >9000 persons with recently diagnosed T2D. We applied multiple mediation analysis using structural equation modelling, with adjustment for age and sex.ResultsWaist circumference as a proxy for abdominal adiposity was positively associated with all inflammatory markers. Hence, a one‐standard deviation (SD) increase in waist circumference (SD = 15 cm) was associated with a 22%, 35%, and 46% SD increase in TNF‐α (SD = 1.5 pg/mL), IL‐6 (SD = 4.4 pg/mL), and hsCRP (SD = 6.9 mg/L), respectively. The level of hyperinsulinaemia assessed by fasting C‐peptide was quantitatively the most important mediator, accounting for 9%–25% of the association between abdominal adiposity and low‐grade inflammation, followed by low physical activity (5%–7%) and high triglyceride levels (2%–6%). Although mediation of adiposity‐induced inflammation by greater comorbidity and higher glycated haemoglobin levels reached statistical significance, their impact was minor (1%–2%).ConclusionsIn persons with recently diagnosed T2D, there was a clear association between abdominal adiposity and low‐grade inflammation. A considerable part (20%–40%) of this association was mediated by other factors, with hyperinsulinaemia as a potentially important driver of adiposity‐induced inflammation in T2D.

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Section: Methodsmentioning

confidence: 99%

“…We measured serum hsCRP (mg/L) with an enzyme-linked immunosorbent assay technique using an in-house time-resolved immunofluorometric assay, as previously described. 18,19 Intra-and inter-assay coefficients of variation were <5% and <6%, respectively.…”

Section: Exposure (Abdominal Adiposity) and Outcomes (Inflammatory Ma...mentioning

confidence: 95%

Low‐grade inflammation in persons with recently diagnosed type 2 diabetes: The role of abdominal adiposity and putative mediators

Domazet,

Olesen,

Stidsen

et al. 2024

Diabetes Obesity Metabolism

View full text Add to dashboard Cite

show abstract

Mannose-binding lectin and risk of infections in type 2 diabetes: A Danish cohort study

Cited by 1 publication

References 45 publications

Low‐grade inflammation in persons with recently diagnosed type 2 diabetes: The role of abdominal adiposity and putative mediators

Low‐grade inflammation in persons with recently diagnosed type 2 diabetes: The role of abdominal adiposity and putative mediators

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