Perineural Invasion Correlates With Common Pathological Variables and Clinical Outcomes of Patients With Squamous Cell Carcinoma of the Vulva Treated With Primary Radical Surgery and Inguinal-femoral Lymphadenectomy

Gadducci, Angiolo; Pistolesi, Sabina; Cosio, Stefania; Comunale, Chiara; Fanucchi, A; Naccarato, Antonio Giuseppe

doi:10.21873/invivo.12349

Cited by 4 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly to other authors, we found that PNI was associated with more advanced stages [ 46 , 48 , 49 ], larger tumors [ 45 , 49 ], greater DOI [ 41 , 45 ], greater lymph node involvement [ 45 , 48 , 50 ], and LVI [ 45 , 46 , 48 , 49 ]; these features suggest that the presence of PNI is associated with more aggressive biological behavior.…”

Section: Discussionsupporting

confidence: 88%

See 1 more Smart Citation

Perineural Invasion in Vulvar Squamous-Cell Carcinoma Is an Independent Risk Factor for Cancer-Specific Survival, but Not for Locoregional Recurrence: Results from a Single Tertiary Referral Center

Micheletti

Borella

Preti

et al. 2021

Cancers

View full text Add to dashboard Cite

The aims of this study were to assess the prevalence of perineural invasion (PNI) in vulvar squamous cell carcinoma (VSCC) and its prognostic role in locoregional recurrence (LRR) and cancer-specific survival (CSS). We performed a retrospective analysis of 223 consecutive stage IB–IIIC surgically treated VSCCs at S. Anna Hospital, University of Turin, from 2000 to 2019. We identified 133/223 (59.6%) patients with PNI-positive VSCCs. PNI was associated with aggressive biological features (i.e., advanced FIGO stage, larger tumor diameter, greater depth of invasion, a higher number of metastatic lymph nodes, and lymphovascular invasion) and shorter 5-year CSS (78% vs. 90%, log-rank p = 0.02) compared with PNI-negative VSCCs. Multivariate analysis showed that PNI (HR 2.99 CI 95% 1.17–7.63; p = 0.02) and the presence of tumor cells on pathological surgical margins (HR 3.13 CI 95% 1.37–7.13; p = 0.007) are independent prognostic factors for CSS. PNI does not appear to be related to LRR, but is an independent prognostic factor for worse survival outcomes. Future studies are necessary to explore the possible value of PNI in tailoring the choice of adjuvant treatment.

show abstract

Section: Discussionsupporting

confidence: 88%

“…Our data showed that PNI is strongly related to CSS. Other authors have also reported an association between PNI positivity and OS according to multivariate [ 46 , 48 ] or univariate analysis [ 45 , 49 , 55 ].…”

Section: Discussionmentioning

confidence: 99%