Protein formulation through automated screening of pH and buffer conditions, using the Robotein® high throughput facility

Kellner, Ruth; Malempré, Romain; Vandenameele, Julie; Brans, Alain; Hennen, Anne-Françoise; Rochus, Noémie; Paolo, Alexandre Di; Vandevenne, Marylène; Matagne, André

doi:10.1007/s00249-021-01510-y

Cited by 2 publications

(1 citation statement)

References 54 publications

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“…The optimisation of sample quality is a big issue in the field, and has been a strong focus of ARBRE-MOBIEU along with the Protein Production and Purification Partnership in Europe (P4EU). Molecular Biophysics and protein production facilities are ideally placed to help standardise the procedures for assessing sample quality (Berrow et al 2021) and aid in stability control with buffer screening approaches (Houser et al 2021, Kellner et al 2021.…”

Section: Scientific Outputs Of the Mobieu Cost Actionmentioning

confidence: 99%

Community-building and promotion of technological excellence in molecular biophysics: the ARBRE–MOBIEU network

England

Jowitt

2021

Eur Biophys J

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The interface between Physics and Biology (Biophysics) has been, for centuries, a fantastically rich environment for scientific and technological innovation.Molecular-scale biophysics is the study of biological systems at an intermediate level between atomic-resolution structural descriptions and cellular-scale observations. It sits at the crossroads of several areas of expertise (Fig. 1), and thus holds a strategic position, critical to cellular, molecular and structural biology, as well as to biomedicine, bio-production and biotechnology. It addresses essential questions on how active biomolecular assemblies form and function. These include insights into their architecture, folding, stability and dynamics, as well as into the energy and kinetics of their interactions, both at ensemble and single-event levels. It is a strongly interdisciplinary field involving physicists, biologists, chemists, as well as medical, bioinformatics and materials scientists.The last decade has witnessed a remarkable expansion in the variety of molecular-scale biophysics technologies, utilising an ever-increasing number of physical phenomena to monitor molecular changes that allow scientists to dissect molecular behaviour and to answer biological problems. These technologies include hydrodynamics, advanced spectroscopies, calorimetry, fast and ultra-fast real-time bio-sensing, native mass spectrometry, and single-molecule

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Section: Scientific Outputs Of the Mobieu Cost Actionmentioning

confidence: 99%

Community-building and promotion of technological excellence in molecular biophysics: the ARBRE–MOBIEU network

England

Jowitt

2021

Eur Biophys J

View full text Add to dashboard Cite

show abstract

Protein formulation through automated screening of pH and buffer conditions, using the Robotein® high throughput facility

Cited by 2 publications

References 54 publications

Community-building and promotion of technological excellence in molecular biophysics: the ARBRE–MOBIEU network

Community-building and promotion of technological excellence in molecular biophysics: the ARBRE–MOBIEU network

Development of a fluorescence-based excipient screening for improved stability and shelf-life of recombinant chitin deacetylase

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