Fungal keratitis associated with the use of contact lenses (clinical case)

Zakirova, G Z

doi:10.17116/oftalma202113701174

Cited by 1 publication

(1 citation statement)

References 17 publications

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“…Contact correction is sometimes accompanied by microtraumas, especially when instructions for SCL are not observed; constant lens wearing can also cause local hypoxia and hypercapnia which influence the ability of epithelium to respond to damage [ 24 ]. The number of registered Fusarium keratitis in patients using SCL is growing [ 25 , 26 ], and rare cases of keratitis induced by opportunistic Arthrograthis kalrae are in absolute majority connected with contact correction [ 27 ]. According to the results of one of the investigations [ 22 ], application of SCL was more often associated with keratitis caused by filamentous fungi (50%) than by yeast ones (18.2%), while ailments of the ocular surface were a widespread risk factor at any etiology.…”

Section: Risk Factorsmentioning

confidence: 99%

Modern Technologies in Diagnosis of Fungal Keratitis (Review)

Sitnova¹,

Svetozarskiy²

2023

Sovrem Tehnol Med

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Traumas and infectious diseases of the eye play a leading role in the development of corneal blindness responsible for 1.5–2 million cases of vision loss per year. To date, the issue of reducing the incidence of fungal keratitis is acute and needs to be solved worldwide. Trauma as a risk factor for corneal fungal disease is thought to be prevalent in developing countries due to agricultural involvement, while in developed countries the onset of the disease is predisposed by medical advances such as contact vision correction and modern ophthalmic surgery. Thorough analysis of the pathogenesis gives the possibility to describe the action of fungal enzymes, biofilm formation, and the resistance mechanism, which on the one hand explains the aggressive course of the disease and difficulties in its diagnosis, and on the other hand, it encourages searching for new methods of diagnosis and treatment. The non-specific clinical picture of fungal keratitis, the variety and availability of antibiotics nowadays become an obstacle for rapid detection of this pathology. Low public awareness and late visit to an ophthalmologist are also a barrier to successful combating the increasing incidence of fungal keratitis. Belated diagnosis, increasing resistance of fungi to antibiotics, and lack of registered antifungal ophthalmic drugs justify poor treatment efficacy resulting in decreased visual acuity or vision loss . Existing diagnostic methods need systematization and detailed comparison, identifying the advantages and disadvantages of each. This review considers causative agents and their influence on pathogenesis of the disease, describes difficulties of fungal keratitis diagnosis and possible ways of overcoming these problems using new developments, and also outlines further prospects of research in this direction.

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