Polymorphisms of 5‐hydroxytryptamine receptor type 3B gene and clinical characteristics for vomiting after breast surgery in chinese han female population

Abstract

What is known and objective The 5‐hydroxytryptamine type 3B receptor (HTR3B) is involved in postoperative vomiting. We aimed to investigate whether genomic variations of rs1176744 and rs1672717 in HTR3B are associated with postoperative vomiting (POV) in the Chinese Han female population after surgery. Methods Five hundred and sixty‐eight female patients classified as ASA I‐II undergoing breast surgery under standard general anaesthesia were enrolled in the study. Episodes of POV in the first 24 h after surgery were recorded. Targeted single nucleotide polymorphisms (SNPs) in the HTR3B gene were identified by genotyping using the SNPscanTM technique. Univariate and multivariate analyses were conducted to investigate the association between SNPs and POV. Results We eventually analysed 407 subjects undergoing breast surgery under general anaesthesia. Of these, 104(25.6%) patients suffered POV within 24 h after surgery. In the multivariate logistic regression analysis, we found that age≥50 years (p = 0.012) and longer duration of surgery (p = 0.019) were independent risk factors for POV. Simultaneously, in the dominant model of rs1672717, compared with the AA genotype, GG+GA carriers suffered more POV (OR=1.669, p = 0.038). However, the use of atropine reduced the incidence of POV in our study (p = 0.019). What is new and conclusion Our investigation demonstrated that polymorphism of rs1672717 (HTR3B) may be a genetic risk factor for developing POV. Trial registration: clinicaltrials.gov identifier: NCT03705026.

Genetic Susceptibility Toward Nausea and Vomiting in Surgical Patients

“…The HTR3B Haplotype Associated With the Most Severe PONV Risk is Present in One Third of the Patients Serotonin signaling through type 3 receptors is known to play an important role in emesis. The strong association observed between three of the HTR3B SNPs and PONV confirms previous reports (Rueffert et al, 2009;Ma et al, 2013;Yan et al, 2021). Moreover, the weaker associations found between the remaining HTR3B and HTR3A related SNPs and PONV occurrence, and to a lesser extend recurrence, further supports the observed link between nausea and vomiting and type 3 serotonin receptors.…”

“…The pro-emetic role of serotonin and the efficiency of antagonists of the type 3 serotonin receptors (5-HTR 3 ), such as ondansetron, as anti-emetic treatment, has prompted a number of studies on the effect of polymorphisms affecting serotonin receptor genes on nausea and vomiting. Several studies uncovered significant associations between HTR3A and HTR3B related genetic polymorphisms and PONV (Rueffert et al, 2009;Laugsand et al, 2011;Lehmann et al, 2013;Ma et al, 2013;Yan et al, 2021). Genetic variations affecting other serotonin receptors such as 5-HTR 2A , might also participate in PONV susceptibility (Kato et al, 2006).…”