A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults

Tiwari, Shashank; Gupta, Sandeep K.; Pathak, Anklesh Kumar

doi:10.1016/j.jep.2021.113929

Cited by 20 publications

(6 citation statements)

References 39 publications

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“…Furthermore, endurance measured by VO 2max also increased significantly in AG group which suggests that the effect, although small in magnitude (8%), might be clinically relevant. This observation is lower compared to a previous study by Tiwari et al, 26 which reported a 16% improvement in VO 2max . Similarly, another study by Choudhary et al 27 observed 13% increase in VO 2max after eight weeks of AG supplementation.…”

Section: Discussioncontrasting

confidence: 75%

Effects of Ashwagandha (Withania somnifera) standardized root extract on physical endurance and VO2max in healthy adults preforming resistance training: An eight-week, prospective, randomized, double-blind, placebo-controlled study

et al. 2023

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Background: Ashwagandha is a well-known Ayurvedic herb used for youthful vigor and wellbeing. This study investigated the effects of 300 mg standardized root extract (>5% withanolides) of Ashwagandha (Withania somnifera) on muscle mass, strength and cardiorespiratory endurance following resistance training. Methods: In this eight-week, parallel-group, multicenter, randomized, double-blind, placebo-controlled clinical study, 80 healthy male and female participants aged 18-45 years, who engaged in regular physical activity were randomly allocated in a 1:1 ratio to receive Ashwagandha (AG, n=40) 300 mg capsules twice daily for eight weeks, or identical placebo (PB, n=40). Seven (3 AG, 4 PB) participants were excluded due to poor compliance. All participants conducted eight-week resistance training. Study outcomes included muscle strength (1RM bench press and leg extension), muscle size (circumference of arm, chest and upper thigh) and cardio-respiratory endurance (VO2max) assessed at baseline and at eight weeks. Analysis of covariance (ANCOVA) was used to estimate adjusted differences based on sex, BMI and chest circumference at baseline. Results: AG caused greater improvement in chest press (males: p = 0.0084; females: p = 0.0005), leg press (males: p = 0.0049; females: p = 0.018) and endurance (males: p <0.0001; females: p <0.0001) as compared to PB. Also, greater improvements in muscle girth for arm, chest and thigh were seen in both male and female participants with AG. No adverse events were reported in the study. Conclusions: Eight weeks of AG root extract supplementation along with resistance training is effective in improving muscle strength, growth, endurance and recovery in both male and female participants. AG root extract could be a safer, effective and low-cost alternative for athletes to improve muscle endurance.

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Section: Discussioncontrasting

confidence: 75%

Effects of Ashwagandha (Withania somnifera) standardized root extract on physical endurance and VO2max in healthy adults preforming resistance training: An eight-week, prospective, randomized, double-blind, placebo-controlled study

et al. 2023

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“…Out of them, 17 records were excluded based on the following reasons: seven studies that evaluated the effect of Ashwagandha in combination with other components, two studies were conducted on children, five studies have not got sufficient information, and three of them were not RCT. Finally, 12 papers fulfilled the inclusion criteria and were included in this meta‐analysis (Abedon, Auddy, Hazra, Mitra, & Ghosal, 2008; Andrade et al, 2000; Chandrasekhar et al, 2012; Chengappa et al, 2013; Chengappa et al, 2018; Choudhary et al, 2017; Khyati & Anup, 2013; Langade, Kanchi, Salve, Debnath, & Ambegaokar, 2019; Langade, Thakare, Kanchi, & Kelgane, 2021; Lopresti, Smith, Malvi, & Kodgule, 2019; Salve et al, 2019; Tiwari, Gupta, & Pathak, 2021). The exact steps of the selection process are shown in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…Perceived Stress Scale (PSS), Recovery‐Stress Questionnaire for Athletes (RESTQ), Depression, Anxiety, and Stress Scale −21 (DASS‐21), modified Hamilton anxiety (mHAM‐A) scale for stress were used to evaluate stress. Moreover, based on Cochrane Collaboration Risk of Bias guideline: six trials were good (Chengappa et al, 2018; Choudhary et al, 2017; Langade et al, 2019; Langade et al, 2021; Lopresti et al, 2019; Tiwari et al, 2021), five trials had a fair quality (Abedon et al, 2008; Chandrasekhar et al, 2012; Chengappa et al, 2013; Khyati & Anup, 2013; Salve et al, 2019), and one trial was poor (Andrade et al, 2000) (Table S1).…”

Section: Resultsmentioning

confidence: 99%

“…The detailed characteristics of the 12 included studies are summarized in Lopresti et al, 2019;Tiwari et al, 2021), five trials had a fair quality (Abedon et al, 2008;Chandrasekhar et al, 2012;Chengappa et al, 2013;Khyati & Anup, 2013;Salve et al, 2019), and one trial was poor (Andrade et al, 2000) (Table S1).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…All studies were performed on both genders. Types and components of intervention are summarized in Table2.These 12 studies conducted on: healthy adults (n = 3)(Lopresti et al, 2019;Salve et al, 2019;Tiwari et al, 2021), adults with insomnia (n = 2)(Langade et al, 2019;Langade et al, 2021), adults with history of chronic stress (n = 3)(Abedon et al, 2008;Chandrasekhar et al, 2012;Choudhary et al, 2017), people with general anxiety disorders (n = 2)(Andrade et al, 2000;Khyati & Anup, 2013), subjects with schizophrenia or schizoaffective disorder (n = 1)(Chengappa et al, 2018), and bipolar adults (n = 1)(Chengappa et al, 2013). Type of questionnaires that were used to assess anxiety includes Hamilton Anxiety Rating Scale (HAM-A) and Depression Anxiety Stress Scale (DASS).…”

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confidence: 99%

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Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? A systematic review and meta‐analysis of randomized controlled trials

Akhgarjand

Asoudeh

Bagheri

et al. 2022

Phytotherapy Research

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Clinical trial studies revealed conflicting results on the effect of Ashwagandha extract on anxiety and stress. Therefore, we aimed to evaluate the effect of Ashwagandha supplementation on anxiety as well as stress. A systematic search was performed in PubMed/Medline, Scopus, and Google Scholar from inception until December 2021.We included randomized clinical trials (RCTs) that investigate the effect of Ashwagandha extract on anxiety and stress. The overall effect size was pooled by randomeffects model and the standardized mean difference (SMD) and 95% confidence interval (CIs) for outcomes were applied. Overall, 12 eligible papers with a total sample size of 1,002 participants and age range between 25 and 48 years were included in the current systematic review and meta-analysis. We found that Ashwagandha supplementation significantly reduced anxiety (SMD: À1.55, 95% CI: À2.37, À0.74; p = .005; I 2 = 93.8%) and stress level (SMD: À1.75; 95% CI: À2.29, À1.22; p = .005; I 2 = 83.1%) compared to the placebo. Additionally, the non-linear dose-response analysis indicated a favorable effect of Ashwagandha supplementation on anxiety until 12,000 mg/d and stress at dose of 300-600 mg/d. Finally, we identified that the certainty of the evidence was low for both outcomes. The current systematic review and dose-response meta-analysis of RCTs revealed a beneficial effect in both stress and anxiety following Ashwagandha supplementation. However, further highquality studies are needed to firmly establish the clinical efficacy of the plant.

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Phase III randomized clinical trial of BV‐4051, an Ayurvedic polyherbal formulation in moderate SARS‐CoV‐2 infections and its impact on inflammatory biomarkers

Chitre¹,

Nadkarni²,

Jagtap³

et al. 2022

Phytotherapy Research

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SARS‐CoV‐2 virus and its variants continue to be a challenge inspite of widespread vaccination and preventive measures. We hypothesized an oral, safe polyherbal formulation with antiinflammatory properties may improve the clinical outcome of this disease. BV‐4051, a formulation from four Ayurvedic plants namely Ashwagandha, Boswellia, Ginger and Turmeric was used for the treatment of hospitalized moderate COVID‐19 patients along with standard of care (SOC). Patients were randomly assigned to receive BV‐4051 or placebo tablets for 14 days, at four sites in India during late 2020 to early 2021. Among 208 randomized subjects, 175 completed the study. In BV‐4051 group the mean reduction in duration of illness (p = 0.036), alleviation and severity scores of several symptoms like fever, cough, smell, and taste disorders were statistically significant (p ≤ 0.05). A sub‐set analysis of subjects treated with or without Remdesivir as SOC showed mean reduction in duration of illness in BV‐4051 (p = 0.030), and severity scores (p ≤ 0.05). Mean difference in Interleukin‐6 was statistically significant (p = 0.042) on BV‐4051 without Remdesivir. BV‐4051 may reduce duration of illness, symptoms severity, Interleukin‐6, and prevent the incidence of COVID‐19 complications. It may have an adjunctive effect with other SOC. Larger extensive clinical testing may give a better understanding of its effect.

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A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults

Cited by 20 publications

References 39 publications

Effects of Ashwagandha (Withania somnifera) standardized root extract on physical endurance and VO2max in healthy adults preforming resistance training: An eight-week, prospective, randomized, double-blind, placebo-controlled study

Effects of Ashwagandha (Withania somnifera) standardized root extract on physical endurance and VO2max in healthy adults preforming resistance training: An eight-week, prospective, randomized, double-blind, placebo-controlled study

Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? A systematic review and meta‐analysis of randomized controlled trials

Phase III randomized clinical trial of BV‐4051, an Ayurvedic polyherbal formulation in moderate SARS‐CoV‐2 infections and its impact on inflammatory biomarkers

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