Family environment as a predictor and moderator of cognitive and psychosocial outcomes in children treated for posterior fossa tumors

Durish, Christianne Laliberté; Moxon‐Emre, Iska; Bouffet, Éric; Bartels, Ute; Mabbott, Donald

doi:10.1080/09297049.2021.1885639

Cited by 7 publications

(5 citation statements)

References 49 publications

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“…Children with PFT were seven times more likely to experience problems in school if their mother had a low school degree. This is in line with previous studies on patients with paediatric PFT, which found an association between the education of parents and the child's neuropsychological functioning (Kieffer et al, 2019;Laliberté Durish et al, 2021;Palmer et al, 2013). Interestingly, in the current analyses, paternal school degree had a lower impact than the maternal education.…”

Section: Maternal School Degreesupporting

confidence: 92%

“…Although it is well established that the socio‐economic, cultural and familial background impacts the normal development of a child (Hair et al, 2015 ; Noble et al, 2015 ), it is hardly considered in risk factor studies on survivors of paediatric PFTs (Hocking et al, 2011a ; Kieffer et al, 2019 ; Laliberté Durish et al, 2021 ; Schepers et al, 2021 ). Most studies investigating the influence of environmental factors on the long‐term outcome are conducted on inhomogeneous cohorts of patients with any type of childhood tumour (Ach et al, 2013 ; Barrera et al, 2017 ; Schepers et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…Most studies investigating the influence of environmental factors on the long‐term outcome are conducted on inhomogeneous cohorts of patients with any type of childhood tumour (Ach et al, 2013 ; Barrera et al, 2017 ; Schepers et al, 2021 ). The few studies that focused on children and adolescents with PFTs found an association between parental education and global as well as specific cognitive outcomes such as executive functioning, memory and attention (Kieffer et al, 2019 ; Laliberté Durish et al, 2021 ; Palmer et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

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Sociocultural variables have a major impact on participation in patients treated for paediatric posterior fossa tumours

Hoffmann-Lamplmair

Gram

Krottendorfer

et al. 2022

Child

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Background This study investigates the severeness of participation barriers in patients surviving paediatric posterior fossa tumours (PFT) many years after treatment. In the past, aetiological studies on adverse outcome have primarily focused on pathobiological risk factors. The current analysis aims to investigate the importance of environmental variables. Methods On average, 10 years after diagnosis, educational and social difficulties of 42 patients surviving paediatric PFT (mean age 17 years) were inquired using a self‐constructed questionnaire following the Psychosocial Resource‐Orientated Assessment (PREDI). Educational or social participation barriers were defined by self‐ and/or proxy‐reported difficulties in school or in peer relationships. Accordingly, the children and adolescents were categorized into groups of adequate and limited participation. Subsequently, the study identified potential pathobiological (treatment type, hydrocephalus, tumour relapse, gender, age at diagnosis, seizures and cerebellar mutism) and environmental (parental and maternal education, siblings, main language, discrepancies between personal and environmental values, regular physical activity and private living space) risk factors and investigated whether patients with adequate and limited participation differed in the number of risk factors. Results Almost one decade after treatment, two thirds of patients experienced educational and/or social difficulties. Patients with limited participation were more frequently associated with environmental factors such as low maternal education degree, siblings, main language other than German, discrepancies between societal and personal values and irregular physical activity, as well as the pathobiological risk factors treatment type, hydrocephalus, tumour relapse, cerebellar mutism and seizures. These variables significantly discriminated between patients with and without limited participation. Conclusions Limited participation in patients treated for paediatric PFT is common. Next to pathobiological, also environmental risk factors play a major role in educational and social participation barriers. This highlights the fact that solely considering pathobiology is not sufficient when investigating risk factors for the emergence of late sequelae. Future aetiological studies must adopt a biopsychosocial perspective.

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Section: Maternal School Degreesupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Sociocultural variables have a major impact on participation in patients treated for paediatric posterior fossa tumours

Hoffmann-Lamplmair

Gram

Krottendorfer

et al. 2022

Child

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“…There has been increasing interest in appreciating the relationship between family environmental factors and child neuropsychological function across medical populations, most notably childhood traumatic brain injury (Durish et al, 2018; Taylor et al, 2002; Wade et al, 2011; Yeates et al, 2010). Pediatric oncology researchers inconsistently consider the role of family environmental factors such as two parent households, parental education and occupation, and familial supports, despite the albeit limited research suggesting a relationship between family function and neuropsychological outcomes (Ach et al, 2013; Kullgren et al, 2003; Laliberté Durish et al, 2021; Quast et al, 2018). In addition, researchers should consider community and systemic factors that impact the child’s environment as well, such as via the Area Deprivation Index (ADI), which considers social determinants of health within the child’s community including education quality, income/employment, neighborhood housing, and household characteristics.…”

Section: Discussionmentioning

confidence: 99%

A systematic review of pediatric neuropsychological outcomes with proton versus photon radiation therapy: A call for equity in access to treatment

Peterson

King

2022

J Int Neuropsychol Soc

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Objective: There is increasing interest in the utilization of proton beam radiation therapy (PRT) to treat pediatric brain tumors based upon presumed advantages over traditional photon radiation therapy (XRT). PRT provides more conformal radiation to the tumor with reduced dose to healthy brain parenchyma. Less radiation exposure to brain tissue beyond the tumor is thought to reduce neuropsychological sequelae. This systematic review aimed to provide an overview of published studies comparing neuropsychological outcomes between PRT and XRT. Method: PubMed, PsychINFO, Embase, Web of Science, Scopus, and Cochrane were systematically searched for peer-reviewed published studies that compared neuropsychological outcomes between PRT and XRT in pediatric brain tumor patients. Results: Eight studies were included. Six of the studies utilized retrospective neuropsychological data; the majority were longitudinal studies (n = 5). XRT was found to result in lower neuropsychological functioning across time. PRT was associated with generally stable neuropsychological functioning across time, with the exception of working memory and processing speed, which showed variable outcomes across studies. However, studies inconsistently included or considered medical and sociodemographic differences between treatment groups, which may have impacted neuropsychological outcomes. Conclusions: Despite methodological limitations, including limited baseline neuropsychological evaluations, temporal variability between radiation treatment and first evaluation or initial and follow-up evaluations, and heterogenous samples, there is emerging evidence of sociodemographic inequities in access to PRT. With more institutions dedicating funding towards PRT, there may be the opportunity to objectively evaluate the neuropsychological benefits of patients matched on medical and sociodemographic variables.

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“…Sociofamilial data will be carefully reported, as they are important to neuropsychological outcomes [20] (parents’ occupations, highest degree obtained, and number of years of study). Data concerning the disease, initial symptomatology, initial hydrocephalus and tumor location, details of surgical management, radiotherapy and chemotherapy will be collected.…”

Section: Methodsmentioning

confidence: 99%

A prospective behavioral and imaging study exploring the impact on long-term memory of radiotherapy delivered for a brain tumor in childhood and adolescence

Baudou

Pariente

Péran

et al. 2022

Clinical and Translational Radiation Oncology

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Highlights Common long-term memory defects after pediatric brain tumor affect school achievement The hippocampi, the cerebellum and cerebellar-cortical networks play a role in several memory systems. This study will provide long-term neuropsychological data about four different memory systems. We will investigate the correlations between neuropsychological, neuroimaging and radiotherapy dose data. Imaging will be structural (3DT1), microstructural (DTI), functional (rs-fMRI), vascular (ASL) and metabolic (spectroscopy).

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Family environment as a predictor and moderator of cognitive and psychosocial outcomes in children treated for posterior fossa tumors

Cited by 7 publications

References 49 publications

Sociocultural variables have a major impact on participation in patients treated for paediatric posterior fossa tumours

Sociocultural variables have a major impact on participation in patients treated for paediatric posterior fossa tumours

A systematic review of pediatric neuropsychological outcomes with proton versus photon radiation therapy: A call for equity in access to treatment

A prospective behavioral and imaging study exploring the impact on long-term memory of radiotherapy delivered for a brain tumor in childhood and adolescence

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