Modulation of the Canonical Wnt Signaling Pathway by Dietary Polyphenols, an Opportunity for Colorectal Cancer Chemoprevention and Treatment

Villota, Hernán; Röthlisberger, Sarah; Pedroza-Díaz, Johanna

doi:10.1080/01635581.2021.1884730

Cited by 17 publications

(10 citation statements)

References 89 publications

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“…Recently, Si et al disclosed that silibinin treatment promoted mitochondrial fusion by suppressing the expression of DRP1 and enhancing the expression of Mfn1, Mfn2, and OPA1, leading to attenuated migration and invasion of breast cancer cells [ 94 ]. Additionally, silibinin plays an important role in other cancer cells such as colorectal cancer [ 95 ], ovarian cancer [ 96 ], and lung cancer [ 97 ] cells, and could serve as a potential therapeutic biomolecule. Doxorubicin (Dox) is a highly effective chemotherapy drug used to treat solid tumors and hematological malignancies.…”

Section: Resultsmentioning

confidence: 99%

Roles of mitochondrial fusion and fission in breast cancer progression: a systematic review

Xing

Liu

et al. 2022

World J Surg Onc

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Background Mitochondria play critical roles in cellular physiological activity as cellular organelles. Under extracellular stimulation, mitochondria undergo constant fusion and fission to meet different cellular demands. Mitochondrial dynamics, which are involved in mitochondrial fusion and fission, are regulated by specialized proteins and lipids, and their dysregulation causes human diseases, such as cancer. The advanced literature about the crucial role of mitochondrial dynamics in breast cancer is performed. Methods All related studies were systematically searched through online databases (PubMed, Web of Science, and EMBASE) using keywords (e.g., breast cancer, mitochondrial, fission, and fusion), and these studies were then screened through the preset inclusion and exclusion criteria. Results Eligible studies (n = 19) were evaluated and discussed in the systematic review. These advanced studies established the roles of mitochondrial fission and fusion of breast cancer in the metabolism, proliferation, survival, and metastasis. Importantly, the manipulating of mitochondrial dynamic is significant for the progresses of breast cancer. Conclusion Understanding the mechanisms underlying mitochondrial fission and fusion during tumorigenesis is important for improving breast cancer treatments.

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Section: Resultsmentioning

confidence: 99%

Roles of mitochondrial fusion and fission in breast cancer progression: a systematic review

Xing

Liu

et al. 2022

World J Surg Onc

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“…Aberrant activation of the Wnt/β-catenin signaling pathway was observed during the occurrence and development of several cancer types, especially CRC . A recent publication also demonstrated that dietary polyphenols, such as Avns and resveratrol, could inactivate the Wnt/β-catenin signaling pathway and had the potential to be used in chemoprevention and treatment of CRC . A study using a tumor necrosis factor α (TNF-α)-induced human arterial smooth muscle cell (HASMC) model indicated that Avn-C treatment contributed to inhibiting cell migration.…”

Section: Classical Bioactivities Of Avnsmentioning

confidence: 99%

“…52 A recent publication also demonstrated that dietary polyphenols, such as Avns and resveratrol, could inactivate the Wnt/βcatenin signaling pathway and had the potential to be used in chemoprevention and treatment of CRC. 53 A study using a tumor necrosis factor α (TNF-α)-induced human arterial smooth muscle cell (HASMC) model indicated that Avn-C treatment contributed to inhibiting cell migration. Compared with HASMCs treated with 100 ng/mL TNF-α, cell migration and migration-related protein matrix metalloproteinase 9 (MMP-9) expression were significantly suppressed after cotreatment with 100 ng/mL TNF-α and 100 μM Avn-C for 24 h, 54 indicating that Avns might also play critical roles in restraining cancer cell migration and even metastasis.…”

Section: Productionmentioning

confidence: 99%

The Progress of Nomenclature, Structure, Metabolism, and Bioactivities of Oat Novel Phytochemical: Avenanthramides

Zhou

et al. 2022

J. Agric. Food Chem.

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Oats are among the most commonly consumed whole grains and are widely grown worldwide, and they contain numerous nutrients, including proteins, lipids, vitamins, minerals, β-glucan, and unique phytochemical polyphenol avenanthramides (Avns). Recent studies have indicated that Avns play essential roles in mediating the health benefits of oats. This review systemically summarized the nomenclature and structures of Avns, effect of germination on promoting Avns production, and in vivo metabolites produced after Avns consumption. The classical functions and novel potential bioactivities of Avns were further elucidated. The classical functions of Avns in cancer prevention, antioxidative response, anti-inflammatory reaction, and maintaining muscle health were expounded, and the internal mechanisms of these functions were analyzed. The potential novel bioactivities of Avns in modulating gut microbiota, alleviating obesity, and preventing chronic diseases, such as atherosclerosis and osteoporosis, were further revealed. This review may provide new prospects and directions for the development and utilization of oat Avns.

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“…Preclinical research indicates that phytochemicals interact with a wide range of molecular and biochemical targets implicated in chemical carcinogenesis, a three-stage process that begins with cancer and progresses through promotion, progression, invasion, and metastasis. In the case of RES, many chemo preventive and chemotherapeutic techniques to halt, prevent, or reverse carcinogenesis stages have been investigated [ 133 ]. RES can disrupt a variety of faulty signaling pathways, allowing it to act as a functionally pleiotropic medication, targeting several targets in cancer cells while inflicting minimal harm to healthy cells.…”

Section: Cellular and Molecular Mechanismsmentioning

confidence: 99%

Involvement of Resveratrol against Brain Cancer: A Combination Strategy with a Pharmaceutical Approach

et al. 2022

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A brain tumor (BT) is a condition in which there is growth or uncontrolled development of the brain cells, which usually goes unrecognized or is diagnosed at the later stages. Since the mechanism behind BT is not clear, and the various physiological conditions are difficult to diagnose, the success rate of BT is not very high. This is the central issue faced during drug development and clinical trials with almost all types of neurodegenerative disorders. In the first part of this review, we focus on the concept of brain tumors, their barriers, and the types of delivery possible to target the brain cells. Although various treatment methods are available, they all have side effects or toxic effects. Hence, in the second part, a correlation was made between the use of resveratrol, a potent antioxidant, and its advantages for brain diseases. The relationship between brain disease and the blood–brain barrier, multi-drug resistance, and the use of nanomedicine for treating brain disorders is also mentioned. In short, a hypothetical concept is given with a background investigation into the use of combination therapy with resveratrol as an active ingredient, the possible drug delivery, and its formulation-based approach.

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Modulation of the Canonical Wnt Signaling Pathway by Dietary Polyphenols, an Opportunity for Colorectal Cancer Chemoprevention and Treatment

Cited by 17 publications

References 89 publications

Roles of mitochondrial fusion and fission in breast cancer progression: a systematic review

Roles of mitochondrial fusion and fission in breast cancer progression: a systematic review

The Progress of Nomenclature, Structure, Metabolism, and Bioactivities of Oat Novel Phytochemical: Avenanthramides

Involvement of Resveratrol against Brain Cancer: A Combination Strategy with a Pharmaceutical Approach

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