High preoperative albumin-bilirubin score predicts poor survival in patients with newly diagnosed high-grade gliomas

Zhang, Jie; Xu, Qian; Zhang, Hua; Zhang, Yihong; Yu, Yang; Luo, Huidan; Lin, Xiaoyan; He, Xing-qin; Mou, Yonggao; Zhou, Zhihuan; He, Zhenqiang

doi:10.1016/j.tranon.2021.101038

Cited by 9 publications

(5 citation statements)

References 47 publications

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“… Zhang et al. 135 Retrospective 324 High-grade glioma ALBI score was independent predictor for both progression-free survival and overall survival in patients who received resection. Zhu et al.…”

Section: Beyond Liver Diseases – Albi In Non-hepatic Tumoursmentioning

confidence: 99%

“…For example, ALBI has been shown to be prognostic in cancers other than HCC, including pancreatic, colon and gastric cancer, intrahepatic cholangiocarcinoma, extrahepatic bile duct cancer, and even brain cancer (glioma and medulloblastoma). [114] , [115] , [116] , [117] , [118] , [119] , [120] , [121] , [122] , [123] , [124] , [125] , [126] , [127] , [128] , [129] , [130] , [131] , [132] , [133] , [134] , [135] , [136] ALBI is likely to be reflective of liver dysfunction in patients undergoing hepatic resection for intrahepatic tumours, such as intrahepatic cholangiocarcinoma or metastatic liver tumours, and tolerance for those undergoing systemic therapy, including chemotherapies, molecular-targeted drugs and immune checkpoint inhibitors. 118 , 123 , [126] , [127] , [128] , 131 , 133 , 134 Although most authors have attempted to link the association of ALBI with a particular cancer to liver function, we should consider whether its association with mortality is actually through some aspect of liver dysfunction or whether it simply reflects the prognostic power of serum albumin and bilirubin levels, independent of liver function.…”

Section: Beyond Liver Diseases – Albi In Non-hepatic Tumoursmentioning

confidence: 99%

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The ALBI score: From liver function in patients with HCC to a general measure of liver function

Toyoda

Johnson

2022

JHEP Reports

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Section: Beyond Liver Diseases – Albi In Non-hepatic Tumoursmentioning

confidence: 99%

Section: Beyond Liver Diseases – Albi In Non-hepatic Tumoursmentioning

confidence: 99%

The ALBI score: From liver function in patients with HCC to a general measure of liver function

Toyoda

Johnson

2022

JHEP Reports

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“…ALBI grade is also useful as a prognostic factor in patients with cholangiocarcinoma ( 20 ), intrahepatic cholangiocarcinoma ( 21 ), colorectal cancer with liver metastases ( 22 ), pancreatic cancer with liver metastases ( 23 ), and primary biliary cholangitis ( 24 ). Furthermore, a strong association between ALBI and mortality has been identified in many non-hepatological conditions, such as gastric cancer ( 25 ), lung cancer ( 16 , 26 , 27 ),esophageal cancer ( 28 ), glioma ( 29 ), medulloblastoma ( 30 ), heart failure ( 31 , 32 ), acute pancreatitis ( 33 ), and aortic dissection ( 34 ).…”

Section: Introductionmentioning

confidence: 99%

Association of easy albumin-bilirubin score with increased mortality in adult trauma patients

Hsu,

Rau,

Tsai

et al. 2024

Front. Surg.

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IntroductionThe easy albumin-bilirubin (EZ-ALBI) score is calculated using the equation: total bilirubin (mg/dl) − 9 × albumin (g/dl), and is used to evaluate liver functional reserve. This study was designed to investigate whether the EZ-ALBI score serves as an independent risk factor for mortality and is useful for stratifying the mortality risk in adult trauma patients.MethodsWe retrospectively reviewed data from the registered trauma database of the hospital and included 3,637 adult trauma patients (1,241 deaths and 2,396 survivors) due to all trauma caused between January 1, 2009, and December 31, 2021. The patients were allocated to the two study groups based on the best EZ-ALBI cutoff point (EZ-ALBI = −28.5), which was determined based on the area under the receiver operating characteristic curve.ResultsResults revealed that the non-survivors had a significantly higher EZ-ALBI score than the survivors (−26.4 ± 6.5 vs. −31.5 ± 6.2, p < 0.001). Multivariate logistic regression analysis revealed that EZ-ALBI ≥ −28.5was an independent risk factor for mortality (odds ratio, 2.31; 95% confidence interval, 1.63–3.28; p < 0.001). Patients with an EZ-ALBI score ≥ −28.5 presented with 2.47-fold higher adjusted mortality rates than patients with an EZ-ALBI score < −28.5. A propensity score-matched pair cohort of 1,236 patients was developed to reduce baseline disparities in trauma mechanisms. The analysis showed that patients with an EZ-ALBI score ≥ −28.5 had a 4.12 times higher mortality rate compared to patients with an EZ-ALBI score < −28.5.ConclusionThe EZ-ALBI score was a significant independent risk factor for mortality and can serve as a valuable tool for stratifying mortality risk in adult trauma patients by all trauma causes.

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“…[21][22][23][24][25][26][27] Patients with cholangiocarcinoma, 28 intrahepatic cholangiocarcinoma, 29 pancreatic cancer with liver metastases, 30 colorectal cancer with liver metastases, 31 and primary biliary cholangitis 32 can all benefit from knowing their ALBI grade as a prognostic indicator. Additionally, other non-hepatological disorders, including aortic dissection, 33 heart failure, 34,35 acute pancreatitis, 36 lung cancer, 24,37,38 esophageal cancer, 39 gastric cancer, 40 lung cancer, 41 and medulloblastoma, 42 have shown a high correlation between ALBI and death.…”

Section: Introductionmentioning

confidence: 99%

The Association of Albumin-Bilirubin (ALBI) Grade with Mortality Risk in Trauma Patients with Liver Injuries

Chou¹,

Rau²,

Su³

et al. 2023

RMHP

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Introduction The albumin-bilirubin (ALBI) grade objectively assesses liver function with better performance than the Child-Pugh and end-stage liver disease scores. However, the evidence is lacking on the ALBI grade in trauma cases. This study aimed to identify the association between the ALBI grade and mortality outcomes in trauma patients with liver injury. Methods Data from 259 patients with traumatic liver injury at a level I trauma center between January 1, 2009, and December 31, 2021 were retrospectively analyzed. Independent risk factors for predicting mortality were identified using multiple logistic regression analysis. Participants were characterized by ALBI score into grade 1 (≤ −2.60, n = 50), grade 2 (−2.60 < and ≤ −1.39, n = 180), and grade 3 (> −1.39, n = 29). Results Compared to survival (n = 239), death (n = 20) was associated with a significantly lower ALBI score (2.8±0.4 vs 3.4±0.7, p < 0.001). The ALBI score was a significant independent risk factor for mortality (OR, 2.79; 95% CI, 1.27–8.05; p = 0.038). Compared with grade 1 patients, grade 3 patients had a significantly higher mortality rate (24.1% vs 0.0%, p < 0.001) and a longer hospital stay (37.5 days vs 13.5 days, p < 0.001). Discussion This study showed that ALBI grade is a significant independent risk factor and an useful clinical tool to discover liver injury patients who are more susceptible to death.

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High preoperative albumin-bilirubin score predicts poor survival in patients with newly diagnosed high-grade gliomas

Cited by 9 publications

References 47 publications

The ALBI score: From liver function in patients with HCC to a general measure of liver function

The ALBI score: From liver function in patients with HCC to a general measure of liver function

Association of easy albumin-bilirubin score with increased mortality in adult trauma patients

The Association of Albumin-Bilirubin (ALBI) Grade with Mortality Risk in Trauma Patients with Liver Injuries

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