The microbiome in IPF: tissue is not the issue

Molyneaux, Philip L.

doi:10.1136/thoraxjnl-2020-216330

Cited by 1 publication

(1 citation statement)

References 14 publications

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“…(1) subpleural lung regions with advanced honeycombing are considered as inhospitable for bacterial growth; (2) the sample size may not have been adequate, given that 35% of controls had detectable bacterial DNA; (3) end-stage disease may not be representative of the underlying process; (4) controls were represented by donor lungs that were unsuitable for transplantation; (5) it is possible that microbiome plays a role within the airways of IPF but not in the alveoli [49]. Therefore, larger studies on no end-stage ILDs are preferable.…”

Section: The Role Of Lung Microbiome During the Natural History Of Ipfmentioning

confidence: 99%

Lung Microbiome in Idiopathic Pulmonary Fibrosis and Other Interstitial Lung Diseases

Amati

Stainer

Mantero

et al. 2022

IJMS

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Interstitial lung diseases represent a heterogeneous and wide group of diseases in which factors leading to disease initiation and progression are not fully understood. Recent evidence suggests that the lung microbiome might influence the pathogenesis and progression of interstitial lung diseases. In recent years, the utilization of culture-independent methodologies has allowed the identification of complex and dynamic communities of microbes, in patients with interstitial lung diseases. However, the potential mechanisms by which these changes may drive disease pathogenesis and progression are largely unknown. The aim of this review is to discuss the role of the altered lung microbiome in several interstitial lung diseases. Untangling the host–microbiome interaction in the lung and airway of interstitial lung disease patients is a research priority. Thus, lung dysbiosis is a potentially treatable trait across several interstitial lung diseases, and its proper characterization and treatment might be crucial to change the natural history of these diseases and improve outcomes.

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Section: The Role Of Lung Microbiome During the Natural History Of Ipfmentioning

confidence: 99%