Serum milk fat globule-EGF factor 8 protein as a potential biomarker for metabolic syndrome

Abstract

Total number of figures and tables 3 figures and 3 tables List of Abbreviations HDL, high density lipoprotein; MFG-E8, milk fat globule-EGF factor-8; S-MAS, Seoul Metabolic Syndrome; BP, blood pressure; AUROC, area under the receiver operating characteristic curve; CI, confidence interval; OR, odds ratio; HR, hazard ratio; BMI, body mass index; LDL, low density lipoprotein; hsCRP, high sensitivity C-reactive protein.

MFGE-8 identified in fetal mesenchymal-stromal-cell-derived exosomes ameliorates acute hepatic failure pathology

“… 51 It has also been suggested that the reduced serum levels of MFGE-8 in patients with HCC or metabolic syndrome may serve as a diagnostic and prognostic biomarker. 52 , 53 Along these lines, hepatic expression of MFGE-8 is reduced in AHF patients, and the CCl 4 mouse model of AHF ( Figures 5 A and 5B) and MFGE-8 expression in liver pericytes correlates with angiogenesis in IRI. 54 Collectively, the aforementioned observations support a generalized protective role of MFGE-8 across several liver pathologies ( Figure 7 ).…”

Proteomic profiling of serum identifies a molecular signature that correlates with clinical outcomes in COPD

“…Finally, among the 4 proteins of our fingerprint that were up-regulated in Cluster 1, Midkine and Lactadherin, were reported to be prominent during several chronic immune and metabolic disorders, such as atherosclerosis, cardiac, kidney and metabolic diseases [ 34 – 36 ]. Elevated levels of these proteins in Cluster 1 COPD patients are consistent with higher incidence of hypertension, diabetes and use of anti-hypertensive drugs and statins and they support the contribution of cardiometabolic co-morbidities to COPD severity [ 6 , 37 ].…”