Effectiveness of the piperine-supplemented <i>Curcuma longa</i> L. in metabolic control of patients with type 2 diabetes: a randomised double-blind placebo-controlled clinical trial

Neta, Joana Furtado de Figueiredo; Veras, Vivian Saraiva; Sousa, Danilo Ferreira de; Cunha, Maria da Conceição dos Santos Oliveira; Queiroz, Maria Veraci Oliveira; Neto, José Cláudio Garcia Lira; Damasceno, Marta María Coelho; Araújo, Márcio Flávio Moura de; Freitas, Roberto Wagner Júnior Freire de

doi:10.1080/09637486.2021.1885015

Cited by 16 publications

(13 citation statements)

References 24 publications

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“…Overall, 15 out of 48 studies used curcumin that in comparison to the control group produced a significant TG reduction in 10 records (Alqahtani, 2021; Bateni et al, 2021; Cicero et al, 2020; Jazayeri‐Tehrani et al, 2019; Murillo Ortiz et al, 2019; Na et al, 2013; Neta et al, 2021; Panahi et al, 2016; Panahi, Khalili, et al, 2014; Rahmani et al, 2016), in 7 records for TC (Alqahtani, 2021; Jamilian et al, 2020; Jazayeri‐Tehrani et al, 2019; Panahi et al, 2016, 2017; Panahi, Khalili, et al, 2014; Rahmani et al, 2016), in 8 for LDL‐C (Alqahtani, 2021; Jamilian et al, 2020; Jazayeri‐Tehrani et al, 2019; Neta et al, 2021; Panahi et al, 2016, 2017; Rahmani et al, 2016; Usharani et al, 2008), in one for VLDL‐C (Murillo Ortiz et al, 2019) and in 2 for Lp(a) (Panahi et al, 2017; Panahi, Khalili, et al, 2014) and a significant increase in HDL‐C levels in 5 studies (Alqahtani, 2021; Jazayeri‐Tehrani et al, 2019; Panahi et al, 2017; Rahmani et al, 2016; Usharani et al, 2008).…”

Section: Resultsmentioning

confidence: 99%

The effects of phytochemicals on serum triglycerides in subjects with hypertriglyceridemia: A systematic review of randomized controlled trials

Tehrani

Shojaei

Bagherniya

et al. 2023

Phytotherapy Research

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This systematic review aimed to evaluate the efficacy of phytochemicals on lipid parameters in patients with hypertriglyceridemia (HTG). A comprehensive search was performed in PubMed/Medline, Scopus, ISI Web of Science, and Google Scholar from inception up to October 2021 to recognize randomized controlled trials (RCTs) assessing the effects of phytochemicals on lipid profiles in patients with HTG. Forty-eight RCTs including 53 arms and comprising 3,478 HTG patients met the eligibility criteria. Phytochemicals significantly reduced the serum levels of triglycerides in 32 out 53 arms, total cholesterol in 22 out of 51, low-density lipoprotein cholesterol in 21 out of 48, very low-density lipoprotein cholesterol in 1 out of 5, apolipoprotein B in 2 out of 4, and lipoprotein(a) levels in 2 out of 4 arms. Furthermore, phytochemicals supplementation increased the levels of high-density lipoprotein cholesterol in 15 out of 48 arms. In brief, phytochemicals supplementation might have beneficial effects on HTG. In most of the studies, phytochemicals had a favorable effect on at least one of the lipid parameters.

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Section: Resultsmentioning

confidence: 99%

The effects of phytochemicals on serum triglycerides in subjects with hypertriglyceridemia: A systematic review of randomized controlled trials

Tehrani

Shojaei

Bagherniya

et al. 2023

Phytotherapy Research

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“…Only three Zingiberaceae plants have been evaluated for their anti‐diabetes properties through RCTs. The eligible articles including 18 turmeric RCTs (Adab et al, 2019; Adibian et al, 2019; Asadi et al, 2019; Chuengsamarn et al, 2014; Hodaei et al, 2019; Jimenez‐Osorio et al, 2016; Khajehdehi et al, 2011; Maithili Karpaga Selvi et al, 2015; Mokhtari et al, 2021; Na et al, 2013; Neta et al, 2021; Panahi, Khalili, Sahebi, Namazi, Artkin, et al, 2017; Panahi, Khalili, Sahebi, Namazi, Reiner, et al, 2017; Panahi et al, 2018; Rahimi et al, 2016; Shafabakhsh et al, 2020; Sousa et al, 2021; Usharani et al, 2008), 14 ginger RCTs (Arablou et al, 2014; Azimi et al, 2014; Azimi et al, 2016; Carvalho et al, 2020; Carvalho et al, 2021; El Gayar et al, 2019; Khandouzi et al, 2015; Mahluji, Attari, et al, 2013; Mahluji, Ostadrahimi, et al, 2013; Makhdoomi Arzati et al, 2017; Mozaffari‐Khosravi et al, 2014; Shidfar et al, 2015; Talaei et al, 2018; Zare Javid et al, 2019) and 4 cardamom RCTs (Asbaghi et al, 2020; Azimi et al, 2014; Azimi et al, 2016; Shekarchizadeh‐Esfahani et al, 2020), compared Zingiberaceae plants with placebo.…”

Section: Resultsmentioning

confidence: 99%

“…A high risk of bias in blinding the outcome evaluation was observed in four studies because they were single‐blind trials (Azimi et al, 2014, 2016; El Gayar et al, 2019; Usharani et al, 2008). Nine trials had a high risk of incomplete outcome data (Adibian et al, 2019; Asadi et al, 2019; Carvalho et al, 2020; Neta et al, 2021; Panahi, Khalili, Sahebi, Namazi, Artkin, et al, 2017; Panahi, Khalili, Sahebi, Namazi, Reiner, et al, 2017; Panahi et al, 2018; Sousa et al, 2021; Zare Javid et al, 2019). One study had selective reporting bias (Talaei et al, 2018).…”

Section: Resultsmentioning

confidence: 99%

“…Only three Zingiberaceae plants have been evaluated for their anti-diabetes properties through RCTs. The eligible articles including 18 turmeric RCTs (Adab et al, 2019;Adibian et al, 2019;Asadi et al, 2019;Chuengsamarn et al, 2014;Hodaei et al, 2019;Jimenez-Osorio et al, 2016;Khajehdehi et al, 2011;Maithili Karpaga Selvi et al, 2015;Mokhtari et al, 2021;Na et al, 2013;Neta et al, 2021;Panahi, Khalili, Sahebi, Namazi, Artkin, et al, 2017;Panahi, Khalili, Sahebi, Namazi, Reiner, et al, 2017;Panahi et al, 2018;Rahimi et al, 2016;Shafabakhsh et al, 2020;Sousa et al, 2021;Usharani et al, 2008), 14 ginger…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

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Effects of medical plants from Zingiberaceae family on cardiovascular risk factors of type 2 diabetes mellitus: A systematic review and meta‐analysis of randomized controlled trials

Zhang

Chen

Tang

et al. 2022

Journal of Food Biochemistry

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We performed a meta-analysis on randomized controlled trials (RCTs) to evaluate the efficacy of Zingiberaceae on cardiovascular risk factors in type 2 diabetes mellitus (T2DM). PubMed, Web of Science, Embase, The Cochrane Library, and Scopus were searched systematically until October 18, 2021. Thirty-four RCTs with 2154 patients met our inclusion. Pooled analysis indicated that Zingiberaceae can significantly improve body weight (BW) (

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“…E a Curcuma longa L. agiu na redução dos níveis metabólicos em pessoas com diabetes tipo 2. Apresentando uma diminuição significativa da glicemia, hemoglobina glicada e triglicerídeos, sendo assim eficaz no controle glicêmico (Neta et al, 2021).…”

Section: Discussionunclassified

Uso de fitoterápicos para controle da glicemia em pacientes diabéticos na atenção básica

Silva

Oliveira²

2022

RSD

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A complexidade da diabetes, seu impacto na qualidade de vida e a importância da prevenção precoce de suas complicações são aspectos cruciais ao se considerar a gestão da doença. Nesse contexto, surgem os fitoterápicos, medicamentos obtidos utilizando apenas a matéria-prima vegetal ativa que possuem diversas vantagens em relação aos medicamentos sintéticos, como o baixo custo, o fácil manuseio e a ampla aprovação popular, graças ao conhecimento dos efeitos terapêuticos das plantas. Dessa forma, por meio de uma revisão de literatura integrativa, o presente estudo objetivou entender e melhor conhecer as principais plantas medicinais, popularmente utilizadas pelos portadores de DM, com a finalidade de diminuir a glicemia. Sabe-se que indivíduos portadores de diabetes apresentam disfunções em seu funcionamento metabólico, de modo que, por necessitar de uma terapia constante, sempre surgem oportunidades para descobertas de métodos eficazes, de fácil acesso e baixo custo que auxiliem no tratamento desta enfermidade. Assim, segundo Mattos e colaboradores (2018), algumas das plantas mais citadas na literatura, visto seu potencial antidiabético, foram as: Bauhinia forficata, Aloe vera, Allium sativum, Beta vulgaris, Rauwolfia serpentina, Momordica charantia, Nigella sativa, Trigonella foenum-graecum e Curcuma longa L. Nesse sentido, evidencia-se a necessidade de uma boa anamnese clínica e nutricional do paciente. Passando a prestar um serviço complementar e integrativo, estando ciente dos possíveis efeitos colaterais que esses produtos podem vir a ocasionar.

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Effectiveness of the piperine-supplemented Curcuma longa L. in metabolic control of patients with type 2 diabetes: a randomised double-blind placebo-controlled clinical trial

Cited by 16 publications

References 24 publications

The effects of phytochemicals on serum triglycerides in subjects with hypertriglyceridemia: A systematic review of randomized controlled trials

The effects of phytochemicals on serum triglycerides in subjects with hypertriglyceridemia: A systematic review of randomized controlled trials

Effects of medical plants from Zingiberaceae family on cardiovascular risk factors of type 2 diabetes mellitus: A systematic review and meta‐analysis of randomized controlled trials

Uso de fitoterápicos para controle da glicemia em pacientes diabéticos na atenção básica

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