Diagnostic performance of 68Ga-DOTATOC PET/CT in tumor-induced osteomalacia

Kato, Atsuko; Nakamoto, Yuji; Ishimori, Takayoshi; Hayakawa, Nobuyuki; Ueda, Masashi; Temma, Takashi; Sano, Kohei; Shimizu, Yoichi; Saga, Tsuneo; Togashi, Kaori

doi:10.1007/s12149-021-01575-x

Cited by 6 publications

(5 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, several studies demonstrated a similar high diagnostic accuracy of 68 Ga-DOTA-NOC and 68 Ga-DOTA-TOC for the localization of TIO ( 4 , 5 , 11 , 28 , 29 ). Nevertheless, three series have reported less promising detection rates of 55%, 53%, and 57%, respectively, with 68 Ga-DOTA-TATE, 68 Ga-DOTA-NOC, and 68 Ga-DOTA-TOC PET/CT ( 3 , 9 , 10 ).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of 99mTc-HYNIC-TOC SPECT/CT for detecting osteomalacia-associated tumors

Duan

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

ObjectivesTumor-induced osteomalacia (TIO) is a rare acquired paraneoplastic disorder characterized by hypophosphatemia resulting from tumor-secreted fibroblast growth factor-23 (FGF23). Surgical resection of the culprit TIO is the first choice of treatment. However, TIO is difficult to detect with conventional diagnostic tools due to its small size and variable location in the body. Somatostatin receptor scintigraphy (SSR) has recently emerged as a functional molecular imaging choice for TIO detection and localization. This research was undertaken to evaluate the efficacy of 99mTc-labeled hydrazinonicotinyl-Tyr3-octreotide (99mTc-HYNIC-TOC) SPECT/CT in detecting TIO.Methods99mTc-HYNIC-TOC SPECT/CT and the available clinical data of 25 patients with suspected TIO were analyzed retrospectively. The 99mTc-HYNIC-TOC SPECT/CT findings were compared with the post-surgical pathology diagnosis and clinical follow-up results.ResultsUsing 99mTc-HYNIC-TOC SPECT/CT, suspicious tumors were found in 18 of the 25 patients, and 15 of them underwent surgical resection. The post-operative pathology confirmed a TIO in those 13 patients whose symptoms and biochemical anomalies gradually resolved after the surgery. The remaining five patients were finally considered false positives. Moreover, the 99mTc-HYNIC-TOC SPECT/CT results were negative in seven patients, with six patients being true negative (4 patients were diagnosed with acquired Fanconi syndrome and 2 patients responded well to conservative therapy) and one being false negative. Therefore, the sensitivity and specificity values of 99mTc-HYNIC-TOC SPECT/CT in the evaluation of TIO were 92.9% (13/14) and 54.5% (6/11), respectively. The overall accuracy of 99mTc-HYNIC-TOC SPECT/CT for detecting TIO was 76.0% (19/25).ConclusionsThe 99mTc-HYNIC-TOC SPECT/CT is an accurate imaging modality for locating culprit tumors in TIO.

show abstract

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of 99mTc-HYNIC-TOC SPECT/CT for detecting osteomalacia-associated tumors

Duan

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…The utility of SR-PET/CT in searching for PMT was reported by Paquet et al, who revealed a relatively high sensitivity (73%) and specificity (67%) of 68 Ga-DOTATOC-PET/CT in 15 patients with suspected TIO [ 25 ]. Additionally, in Japan, the detection rate of 68 Ga-DOTATOC-PET/CT performed at Kyoto University among 35 patients with suspected TIO was reported to be 57% (20/35) [ 41 ], which was superior to the detection rate of F-PET/CT (14/30, 47%) and SRS (13/30, 43%) and was similar to that of FGF23VS (18/30, 60%) in the current study when the 12 patients with unidentified PMTs were added to the 18 patients with identified PMTs, as the previous study did. In addition, among patients without identified tumors with FDG-PET, SRS, and FGF23VS, 5 patients (cases 3, 5, 6, 7, and 13) were referred to Kyoto University Hospital to be subject to 68 Ga-DOTATOC-PET/CT, and the accumulation of tracer was identified in case 3 ( Fig.…”

Section: Discussionmentioning

confidence: 99%

Utility of Multimodality Approach Including Systemic FGF23 Venous Sampling in Localizing Phosphaturic Mesenchymal Tumors

Katô

Koga

Kinoshita

et al. 2022

Journal of the Endocrine Society

Self Cite

View full text Add to dashboard Cite

Context Tumor-induced osteomalacia (TIO) is one of the most common forms of acquired fibroblast growth factor 23 (FGF23)-related hypophosphatemia and is usually caused by phosphaturic mesenchymal tumors (PMTs). Although the complete resection of PMTs can cure TIO, preoperative localization of tumors by standard imaging modalities is often challenging. In addition to 18F-FDG PET/CT (FDG-PET) and 111In-pentetreotide scintigraphy (SRS), systemic FGF23 venous sampling (FGF23VS) has been used to help localize PMTs in specialized institutions. Objective To evaluate the diagnostic performance of each imaging test and their combinations in localizing PMTs. Design Observational retrospective study. Patients Patients with adult-onset FGF23-related osteomalacia who underwent all of the following imaging studies: FDG-PET, SRS, and FGF23VS. Main outcome measures The rate of successful preoperative localization of the tumors was evaluated only in the patients with pathological diagnoses of PMTs, considering the possibility that pathogenesis of patients without identified tumors might be other causes such as late-onset hereditary FGF23-related hypophosphatemia. Results A total of 30 Japanese patients with TIO (median age, 60 years [range, 28-87 years]; 10 women [33.3%]) were included in the study. The success rate of preoperative localization for each test and combinations of two or three tests among 18 patients with PMTs was as follows: 72% (FDG-PET), 72% (SRS), 94% (FGF23VS), 89% (FDG-PET, SRS), 100% (FDG-PET, FGF23VS), 94% (SRS, FGF23VS), and 100% (FDG-PET, SRS, and FGF23VS). Conclusion We observed the highest localization rate of PMTs in patients with identified PMTs with the combination of FDG-PET and FGF23VS.

show abstract

“…These somatostatin receptors can specifically bind to somatostatin to locate the tumor. 68 Ga-DOTATATE, a 68 Ga-labeled somatostatin analogue, is the most common imaging agent used to locate TIO lesions [32] . Preoperative 18 F-FDG PET/CT positivity can indicate an increased likelihood of TIO recurrence after surgical resection [33] .…”

Section: Diagnosismentioning

confidence: 99%

Preoperative evaluation and orthopedic surgical strategies for tumor-induced osteomalacia

Liu,

Zhou,

Liu

et al. 2024

Journal of Bone Oncology

View full text Add to dashboard Cite

Diagnostic performance of 68Ga-DOTATOC PET/CT in tumor-induced osteomalacia

Cited by 6 publications

References 36 publications

Diagnostic accuracy of 99mTc-HYNIC-TOC SPECT/CT for detecting osteomalacia-associated tumors

Diagnostic accuracy of 99mTc-HYNIC-TOC SPECT/CT for detecting osteomalacia-associated tumors

Utility of Multimodality Approach Including Systemic FGF23 Venous Sampling in Localizing Phosphaturic Mesenchymal Tumors

Preoperative evaluation and orthopedic surgical strategies for tumor-induced osteomalacia

Contact Info

Product

Resources

About