Matrix stiffening by self-mineralizable guided bone regeneration

Li, Jing; Yan, Jian fei; Wan, Qian; Shen, Min; Yu, Xuan; Gu, Jun Ting; Gao, Peng; Tang, Xiao Yi; Yang, Fan; Chen, Ji Hua; Tay, Franklin R.; Jiao, Kai; Niu, Li Na

doi:10.1016/j.actbio.2021.02.012

Cited by 40 publications

(44 citation statements)

References 67 publications

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“…ECM is involved in cellular metabolism via regulating glucose, lipid, and amino acid metabolism [ 56 ]. Recent in-depth studies have shown that extracellular matrix stiffness has been implicated in BMSC differentiation via regulating energy metabolism [ 57 , 58 ]. In vitro study has confirmed that cultured hMSCs on stiff (20 kPa) substrate showed enhanced osteogenesis accompanied by higher intracellular ATP levels and AMPK activation than on soft (1 kPa) substrate [ 57 ].…”

Section: Environmental Stress Hormone Drugs and Biological/pathologic...mentioning

confidence: 99%

“…AMPK inhibitor treatment decreased ATP levels and osteogenesis marker ALP expression in hMSCs while AMPK activators can reverse ATP and ALP levels [ 57 ]. Other recent work has also proved that the HPAA (high-molecular-weight polyacrylic acid)-crosslinked collagen membranes (HCM) can self-mineralize and simulate extracellular matrix (ECM) stiffness, which expedites in situ bone regeneration to guide osteogenic differentiation of BMSCs [ 58 , 59 ]. Regarding the mechanism, HCM promotes mitochondriogenesis and declines mitochondria fission to respond to high energy demand during osteogenic differentiation of BMSCs [ 59 ].…”

Section: Environmental Stress Hormone Drugs and Biological/pathologic...mentioning

confidence: 99%

See 1 more Smart Citation

Update on the effects of energy metabolism in bone marrow mesenchymal stem cells differentiation

Ning¹,

Liu²,

Bi³

et al. 2022

Molecular Metabolism

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Section: Environmental Stress Hormone Drugs and Biological/pathologic...mentioning

confidence: 99%

Section: Environmental Stress Hormone Drugs and Biological/pathologic...mentioning

confidence: 99%

Update on the effects of energy metabolism in bone marrow mesenchymal stem cells differentiation

Ning¹,

Liu²,

Bi³

et al. 2022

Molecular Metabolism

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“…It was also demonstrated in vitro that increasing the stiffness of a mineralized collagen glycosaminoglycan matrix allow osteoblastogenesis from bone marrow-derrived hMSCs through YAP/TAZ activation ( Zhou et al, 2021 ). This result was elegantly confirmed during in situ bone regeneration in a bone defect model with a self-mineralizable matrix inducing osteoblastogenesis from MSC across time according to the level of mineralization ( Li J. et al, 2021 ). It was demonstrated that stiffness could modulate YAP/TAZ through RAP2 downstream of the phospholipase Cγ1 ( Meng et al, 2018 ).…”

Section: Yap and Taz Biologymentioning

confidence: 68%

YAP/TAZ in Bone and Cartilage Biology

Zarka

Haÿ

Cohen‐Solal

2022

Front. Cell Dev. Biol.

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YAP and TAZ were initially described as the main regulators of organ growth during development and more recently implicated in bone biology. YAP and TAZ are regulated by mechanical and cytoskeletal cues that lead to the control of cell fate in response to the cellular microenvironment. The mechanical component represents a major signal for bone tissue adaptation and remodelling, so YAP/TAZ contributes significantly in bone and cartilage homeostasis. Recently, mice and cellular models have been developed to investigate the precise roles of YAP/TAZ in bone and cartilage cells, and which appear to be crucial. This review provides an overview of YAP/TAZ regulation and function, notably providing new insights into the role of YAP/TAZ in bone biology.

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“…Additionally, osteogenesis from mesenchymal stem cells was induced. Molecularly, a clear nuclear accumulation of both YAP and TAZ was registered, which shows both the decisive role of both proteins for osteogenesis and the applicability of such dynamic materials for regenerative purposes [378]. The complex histological composition of the periodontium will, therefore, be an optimal candidate to apply such self-regulating biomaterials, which is especially important regarding tissue-tissue interfaces [148,379].…”

Section: May the Force Be With You: Mt And Its Implications For Periodontal Regenerationmentioning

confidence: 95%

From the Matrix to the Nucleus and Back: Mechanobiology in the Light of Health, Pathologies, and Regeneration of Oral Periodontal Tissues

et al. 2021

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Among oral tissues, the periodontium is permanently subjected to mechanical forces resulting from chewing, mastication, or orthodontic appliances. Molecularly, these movements induce a series of subsequent signaling processes, which are embedded in the biological concept of cellular mechanotransduction (MT). Cell and tissue structures, ranging from the extracellular matrix (ECM) to the plasma membrane, the cytosol and the nucleus, are involved in MT. Dysregulation of the diverse, fine-tuned interaction of molecular players responsible for transmitting biophysical environmental information into the cell’s inner milieu can lead to and promote serious diseases, such as periodontitis or oral squamous cell carcinoma (OSCC). Therefore, periodontal integrity and regeneration is highly dependent on the proper integration and regulation of mechanobiological signals in the context of cell behavior. Recent experimental findings have increased the understanding of classical cellular mechanosensing mechanisms by both integrating exogenic factors such as bacterial gingipain proteases and newly discovered cell-inherent functions of mechanoresponsive co-transcriptional regulators such as the Yes-associated protein 1 (YAP1) or the nuclear cytoskeleton. Regarding periodontal MT research, this review offers insights into the current trends and open aspects. Concerning oral regenerative medicine or weakening of periodontal tissue diseases, perspectives on future applications of mechanobiological principles are discussed.

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Matrix stiffening by self-mineralizable guided bone regeneration

Cited by 40 publications

References 67 publications

Update on the effects of energy metabolism in bone marrow mesenchymal stem cells differentiation

Update on the effects of energy metabolism in bone marrow mesenchymal stem cells differentiation

YAP/TAZ in Bone and Cartilage Biology

From the Matrix to the Nucleus and Back: Mechanobiology in the Light of Health, Pathologies, and Regeneration of Oral Periodontal Tissues

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