Alginate coating modifies the biological effects of cerium oxide nanoparticles to the freshwater bivalve Dreissena polymorpha

Torre, Camilla Della; Maggioni, Daniela; Nigro, Lara; Farè, Fiorenza; Hamza, Hady; Protano, Giuseppe; Magni, Stefano; Fontana, Manuela; Riccardi, Nicoletta; Chiara, Matteo; Caruso, Donatella; Binelli, Andrea

doi:10.1016/j.scitotenv.2021.145612

Cited by 11 publications

(13 citation statements)

References 79 publications

(66 reference statements)

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“…Corona formed by alginate and chitosan on nCeO 2 did not affect the biouptake, but alginate coated nCeO 2 induced lipidic peroxidation in marine bivalve Mytilus galloprovincialis (Nigro et al, 2021) and altered energetic metabolism and osmoregulation in freshwater bivalve Dreissena polymorpha Frontiers in Toxicology frontiersin.org (Della Torre et al, 2021). Interestingly, long-term exposure at low concentrations to nCeO 2 coated with alginate and chitosan showed significant modulation of electron transport system activity, suggesting a different strategy of defense in response short -term high concentration nCeO 2 exposure (Nigro et al, 2021). Proteins present in gill mucus of blue mussel Mytilus edulis formed a corona on nSiO 2 and five different types of nTiO 2 (size and crystal structure); some few proteins in the corona showed a specific recruitment pattern according to the NPs type or crystal structure (Bourgeault et al, 2017).…”

Section: Biomolecular Corona and Invertebrates Exogenous Corona Forma...mentioning

confidence: 88%

“…The existing literature revealed that the exogenous corona formed in the medium surrounding invertebrates is dominated by proteins and confirm its importance as a modulator of NP uptake and toxicity to invertebrates (Nasser et al, 2020). Corona formed by alginate and chitosan on nCeO 2 did not affect the biouptake, but alginate coated nCeO 2 induced lipidic peroxidation in marine bivalve Mytilus galloprovincialis (Nigro et al, 2021) and altered energetic metabolism and osmoregulation in freshwater bivalve Dreissena polymorpha Frontiers in Toxicology frontiersin.org (Della Torre et al, 2021). Interestingly, long-term exposure at low concentrations to nCeO 2 coated with alginate and chitosan showed significant modulation of electron transport system activity, suggesting a different strategy of defense in response short -term high concentration nCeO 2 exposure (Nigro et al, 2021).…”

Section: Biomolecular Corona and Invertebrates Exogenous Corona Forma...mentioning

confidence: 89%

“…Proteins present in gill mucus of blue mussel Mytilus edulis formed a corona on nSiO 2 and five different types of nTiO 2 (size and crystal structure); some few proteins in the corona showed a specific recruitment pattern according to the NPs type or crystal structure (Bourgeault et al, 2017). The interactions of NPs with natural bio-molecules, e.g., polysaccharides which and largely present in the marine environment, and impart negative charge to the NPs in particular, could affect NPs toxicity by altering the interactions towards organisms and enhancing NPs biological effects (Nigro et al, 2021).…”

Section: Biomolecular Corona and Invertebrates Exogenous Corona Forma...mentioning

confidence: 98%

“…nCeO 2 electron transport system activity modulation, enhanced antioxidant SOD, GPx, and GST activity, GR activity decreaseNigro et al (2021) soft tissue, the alteration of different morphological and functional characteristics of mussel hemocytes and gill cells, experiencing oxidative stress and the genotoxicity due released AgKatsumiti et al (2015) GPx, Glutathione peroxidase; GR, Glutathione reductase; GST, Glutathione S-transferase; MAPK, Mitogen-activated protein kinase; MgC1q6 protein, Mytilus galloprovincialis putative Complement Component C1q domain; MoA, Mode of action; PS, Polysytene; PVP, Polyvinylpyrrolidone; ROS, Reactive oxygen species; SOD, Superoxyde dismutase.…”

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confidence: 98%

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Aquatic organisms modulate the bioreactivity of engineered nanoparticles: focus on biomolecular corona

Liu

Worms²,

Jakšić³

2022

Front. Toxicol.

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The increased use of nanoparticle (NP)-enabled materials in everyday-life products have raised concerns about their environmental implications and safety. This motivated the extensive research in nanoecotoxicology showing the possibility that NPs could cause harm to the aquatic organisms if present at high concentrations. By contrast, studies dealing with influence that organisms could exert on the fate and thus effects of NPs are still very rare. Drawing on the existing up-to-date knowledge we critically discuss the formation of biomolecular corona as one of the mechanisms by which organisms exerted control on the NPs fate in the aquatic and biotic environments. We focused the formation of corona by exogeneous and endogenous biomolecules and illustrated the discussion with the specific example of phytoplankton and aquatic invertebrate species. We highlighted the necessity to incorporate the concept of biomolecular corona within more general framework considering the feedback of aquatic organisms and the control they exert in shaping the fate and impact of NPs in the aquatic and biological environment. In our view such broader perspective will contribute to get novel insights into the drivers of environmental transformations of NPs and their mechanisms, which are important in environmental risk assessment.

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Section: Biomolecular Corona and Invertebrates Exogenous Corona Forma...mentioning

confidence: 88%

Section: Biomolecular Corona and Invertebrates Exogenous Corona Forma...mentioning

confidence: 89%

Section: Biomolecular Corona and Invertebrates Exogenous Corona Forma...mentioning

confidence: 98%

mentioning

confidence: 98%

See 2 more Smart Citations

Aquatic organisms modulate the bioreactivity of engineered nanoparticles: focus on biomolecular corona

Liu

Worms²,

Jakšić³

2022

Front. Toxicol.

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“…The surface modification of nanoparticles using some natural or synthetic biodegradable polymers can not only improve the biocompatibility of the particles, but also bestow the nanoparticles with additional functions resulting from the changed surface properties [ 5 ]. Some researchers have reported that surface modification with alginate and chitosan [ 25 ], polyvinyl pyrrolidone (PVP) [ 26 ], polyethylene glycol (PEG) [ 27 ], dextran [ 28 ], or polyacrylic acid (PAA) [ 29 ] greatly improves the enzyme activity and stability of cerium oxide nanoparticles in water. In addition, peptides are widely used for surface modification of nanomaterials to enhance the targeting ability, improve the biocompatibility, and bestow the nanoparticles with some peptide-associated biological functions [ 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation, Characterization and Multiple Biological Properties of Peptide-Modified Cerium Oxide Nanoparticles

Wang

Liu

et al. 2022

Biomolecules

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Although cerium oxide nanoparticles are attracting much attention in the biomedical field due to their unique physicochemical and biological functions, the cerium oxide nanoparticles greatly suffer from several unmet physicochemical challenges, including loss of enzymatic activity during the storage, non-specific cellular uptake, off-target toxicities, etc. Herein, in order to improve the targeting property of cerium oxide nanoparticles, we first modified cerium oxide nanoparticles (CeO2) with polyacrylic acid (PAA) and then conjugated with an endothelium-targeting peptide glycine-arginine-aspartic acid (cRGD) to construct CeO2@PAA@RGD. The physiochemical characterization results showed that the surface modifications did not impact the intrinsic enzymatic properties of CeO2, including catalase-like (CAT) and superoxide dismutase-like (SOD) activities. Moreover, the cellular assay data showed that CeO2@PAA@RGD exhibited a good biocompatibility and a higher cellular uptake due to the presence of RGD targeting peptide on its surface. CeO2@PAA@RGD effectively scavenged reactive oxygen species (ROS) to protect cells from oxidative-stress-induced damage. Additionally, it was found that the CeO2@PAA@RGD converted the phenotype of macrophages from proinflammatory (M1) to anti-inflammatory (M2) phenotype, inhibiting the occurrence of inflammation. Furthermore, the CeO2@PAA@RGD also promoted endothelial cell-mediated migration and angiogenesis. Collectively, our results successfully demonstrate the promising application of CeO2@PAA@RGD in the future biomedical field.

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Current overview on production, application, release, and environmental risk associated with nanomaterials

Bhardwaj¹,

Sharma²

2022

Toxicity of Nanoparticles in Plants

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Alginate coating modifies the biological effects of cerium oxide nanoparticles to the freshwater bivalve Dreissena polymorpha

Cited by 11 publications

References 79 publications

Aquatic organisms modulate the bioreactivity of engineered nanoparticles: focus on biomolecular corona

Aquatic organisms modulate the bioreactivity of engineered nanoparticles: focus on biomolecular corona

Preparation, Characterization and Multiple Biological Properties of Peptide-Modified Cerium Oxide Nanoparticles

Current overview on production, application, release, and environmental risk associated with nanomaterials

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