Acute administration of the olive constituent, oleuropein, combined with ischemic postconditioning increases myocardial protection by modulating oxidative defense

Tsoumani, Maria; Georgoulis, Anastasios D.; Νικολάου, Παναγιώτα; Kostopoulos, Ioannis V.; Dermintzoglou, T; Papatheodorou, Ioanna; Ζώγα, Αναστασία; Efentakis, Panagiotis; Konstantinou, Maria; Gikas, Evagelos; Kostomitsopoulos, Nikolaos; Papapetropoulos, Andreas; Lazou, Antigone; Skaltsounis, Alexios Léandros; Hausenloy, Derek J.; Tsitsilonis, Ourania E.; Tseti, Ioulia; Lisa, Fabio Di; Iliodromitis, Efstathios K.; Andreadou, Ioanna

doi:10.1016/j.freeradbiomed.2021.02.011

Cited by 22 publications

(21 citation statements)

References 85 publications

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“…Indeed, it also has anti-inflammatory, anti-atherogenic, anti-tumoral, antimicrobial and neuroprotective effects, among others. Thus, OP offers numerous health benefits; so much so, that it is a potential candidate molecule for the prevention and treatment of such diseases [ 31 , 55 , 56 ]. We observed for the first time that OP is also an excellent defense against MG-dependent glycative stress in DPSCs, thus posing it as a potential candidate in dicarbonyl/glycative stress-related oral disease prevention.…”

Section: Discussionmentioning

confidence: 99%

Methylglyoxal-Dependent Glycative Stress Is Prevented by the Natural Antioxidant Oleuropein in Human Dental Pulp Stem Cells through Nrf2/Glo1 Pathway

et al. 2021

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Methylglyoxal (MG) is a potent precursor of glycative stress (abnormal accumulation of advanced glycation end products, AGEs), a relevant condition underpinning the etiology of several diseases, including those of the oral cave. At present, synthetic agents able to trap MG are known; however, they have never been approved for clinical use because of their severe side effects. Hence, the search of bioactive natural scavengers remains a sector of strong research interest. Here, we investigated whether and how oleuropein (OP), the major bioactive component of olive leaf, was able to prevent MG-dependent glycative stress in human dental pulp stem cells (DPSCs). The cells were exposed to OP at 50 µM for 24 h prior to the administration of MG at 300 µM for additional 24 h. We found that OP prevented MG-induced glycative stress and DPSCs impairment by restoring the activity of Glyoxalase 1 (Glo1), the major detoxifying enzyme of MG, in a mechanism involving the redox-sensitive transcription factor Nrf2. Our results suggest that OP holds great promise for the development of preventive strategies for MG-derived AGEs-associated oral diseases and open new paths in research concerning additional studies on the protective potential of this secoiridoid.

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Section: Discussionmentioning

confidence: 99%

Methylglyoxal-Dependent Glycative Stress Is Prevented by the Natural Antioxidant Oleuropein in Human Dental Pulp Stem Cells through Nrf2/Glo1 Pathway

et al. 2021

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“…Inhibition of AMPK expression can lead to abnormal mitophagy, aggravate oxidative stress and apoptosis levels in the myocardium [ 59 , 60 ]. oleuropein, tilianin, metformin and AICAR have been shown to exert cardioprotective effects as AMPK agonists [ 61 , 62 , 63 , 64 , 65 ]. For example, oleuropein has a strong anti-inflammatory and antioxidant capacity, it can reduce myocardial infarction area and protect cardiac function by upregulating the expression of myocardial AMPK [ 61 , 62 ].…”

Section: Discussionmentioning

confidence: 99%

“…oleuropein, tilianin, metformin and AICAR have been shown to exert cardioprotective effects as AMPK agonists [ 61 , 62 , 63 , 64 , 65 ]. For example, oleuropein has a strong anti-inflammatory and antioxidant capacity, it can reduce myocardial infarction area and protect cardiac function by upregulating the expression of myocardial AMPK [ 61 , 62 ]. AICAR proved to play a cardioprotective role as an AMPK agonist in a variety of disease models (e.g., hypertensive [ 65 ], acute kidney injury [ 66 ], cardiac hypoxia [ 67 ]).…”

Section: Discussionmentioning

confidence: 99%

Exercise Training Enhances Myocardial Mitophagy and Improves Cardiac Function via Irisin/FNDC5-PINK1/Parkin Pathway in MI Mice

Qin

Liang

et al. 2021

Biomedicines

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Myocardial infarction is the major cause of death in cardiovascular disease. In vitro and in vivo models are used to find the exercise mode which has the most significant effect on myocardial irisin/FNDC5 expression and illuminate the cardioprotective role and mechanisms of exercise-activated myocardial irisin/FNDC5-PINK1/Parkin-mediated mitophagy in myocardial infarction. The results indicated that expression of irisin/FNDC5 in myocardium could be up-regulated by different types of exercise and skeletal muscle electrical stimulation, which then promotes mitophagy and improves cardiac function and the effect of resistance exercise. Resistance exercise can improve cardiac function by activating the irisin/FNDC5-PINK1/Parkin-LC3/P62 pathway, regulating mitophagy and inhibiting oxidative stress. OPA1 may play an important role in the improvement of cardiac function and mitophagy pathway in myocardial infarction mice by irisin-mediated resistance exercise. Resistance exercise is expected to become an effective therapeutic way to promote myocardial infarction rehabilitation.

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“…As for the role of Nrf2 signaling pathway in the cardioprotective effects of catechins, it is yet poorly understood. Although activation of Nrf2/HO-1 (heme oxygenase 1) pathway by EPI was documented to be associated with protection against cerebral I/R injury [ 119 ], and its activation was documented in cardioprotective effects of several other polyphenols [ 120 , 121 ], the role of this redox signaling pathway in effects of catechins in myocardial I/R has, in fact, not been evaluated so far. The only study documenting Nrf2/HO-activation in isolated cardiomyocytes due to catechin-including treatment showed that oolong tea rich in catechins prevented hypoxia-induced cardiomyocyte loss by fortifying Nrf2 signaling [ 122 ].…”

Section: Role Of Pro/antioxidant Balance and Redox Signaling In Catechin Effects In Cardiac I/rmentioning

confidence: 99%

Pharmacology of Catechins in Ischemia-Reperfusion Injury of the Heart

et al. 2021

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Catechins represent a group of polyphenols that possesses various beneficial effects in the cardiovascular system, including protective effects in cardiac ischemia-reperfusion (I/R) injury, a major pathophysiology associated with ischemic heart disease, myocardial infarction, as well as with cardioplegic arrest during heart surgery. In particular, catechin, (–)-epicatechin, and epigallocatechin gallate (EGCG) have been reported to prevent cardiac myocytes from I/R-induced cell damage and I/R-associated molecular changes, finally, resulting in improved cell viability, reduced infarct size, and improved recovery of cardiac function after ischemic insult, which has been widely documented in experimental animal studies and cardiac-derived cell lines. Cardioprotective effects of catechins in I/R injury were mediated via multiple molecular mechanisms, including inhibition of apoptosis; activation of cardioprotective pathways, such as PI3K/Akt (RISK) pathway; and inhibition of stress-associated pathways, including JNK/p38-MAPK; preserving mitochondrial function; and/or modulating autophagy. Moreover, regulatory roles of several microRNAs, including miR-145, miR-384-5p, miR-30a, miR-92a, as well as lncRNA MIAT, were documented in effects of catechins in cardiac I/R. On the other hand, the majority of results come from cell-based experiments and healthy small animals, while studies in large animals and studies including comorbidities or co-medications are rare. Human studies are lacking completely. The dosages of compounds also vary in a broad scale, thus, pharmacological aspects of catechins usage in cardiac I/R are inconclusive so far. Therefore, the aim of this focused review is to summarize the most recent knowledge on the effects of catechins in cardiac I/R injury and bring deep insight into the molecular mechanisms involved and dosage-dependency of these effects, as well as to outline potential gaps for translation of catechin-based treatments into clinical practice.

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Acute administration of the olive constituent, oleuropein, combined with ischemic postconditioning increases myocardial protection by modulating oxidative defense

Cited by 22 publications

References 85 publications

Methylglyoxal-Dependent Glycative Stress Is Prevented by the Natural Antioxidant Oleuropein in Human Dental Pulp Stem Cells through Nrf2/Glo1 Pathway

Methylglyoxal-Dependent Glycative Stress Is Prevented by the Natural Antioxidant Oleuropein in Human Dental Pulp Stem Cells through Nrf2/Glo1 Pathway

Exercise Training Enhances Myocardial Mitophagy and Improves Cardiac Function via Irisin/FNDC5-PINK1/Parkin Pathway in MI Mice

Pharmacology of Catechins in Ischemia-Reperfusion Injury of the Heart

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