Recommendations of the schizophrenia expert center network for the screening prevention and treatment of sleep disorders based on the results from the real-world schizophrenia FACE-SZ national cohort

Verville, P L Sunhary de; Etchecopar‐Etchart, Damien; Richieri, Raphaëlle; Godin, O.; Schürhoff, Franck; Berna, Fabrice; Aouizerate, Bruno; Capdevielle, Delphine; Chéreau, Isabelle; d’Amato, Thierry; Dubertret, Caroline; Dubreucq, Julien; Leignier, Sylvain; Mallet, J.; Misdrahi, D.; Passerieux, C.; Pignon, Baptiste; Rey, R.; Urbach, M.; Vidailhet, Pierre; Leboyer, Marion; Llorca, Pierre‐Michel; Lançon, Christophe; Boyer, Laurent; Fond, Guillaume

doi:10.1016/j.pnpbp.2021.110275

Cited by 4 publications

(2 citation statements)

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“…The exact nature of the connection between SCZ and sleep remains elusive, and the findings from scientific investigations show discrepancies, potentially resulting from variations in sample characteristics, confounding variables, and disparities in research approaches. Additionally, the medication administered to individuals with the condition might influence the outcomes of sleep-related analyses ( 19 , 20 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of cognitive training and behavior modification on aggressive behavior and sleep quality in schizophrenia

Wang,

Cheng,

et al. 2024

Front. Psychiatry

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BackgroundSchizophrenia (SCZ) is linked to a heightened risk of impulsive aggression and disturbances in sleep patterns. Cognitive and social cognitive impairments have been connected to aggression, with social cognitive deficits appearing to play a more immediate role. In this investigation, we conducted a retrospective analysis of the impact of cognitive training and sleep interventions on aggressive behavior and the quality of sleep among individuals with SCZ who were hospitalized.MethodsThis study divided 80 hospitalized patients into two groups according to medical advice, namely the normal group and the study group. The control group received routine drug treatment and education; The research group implemented cognitive training and sleep intervention based on the normal group. Collect basic clinical data, aggressive behavior indicators, and sleep quality indicators.ResultsThere is no difference in the basic information statistics between the two groups. Both groups can reduce aggressive behavior and improve sleep quality. In the study group, there was a notable decrease in aggressive behavior compared to the control group. Furthermore, the sleep quality in the study group exhibited significant improvement when compared to the control group.ConclusionCognitive training and sleep intervention have been proven to be effective nonpharmacological treatments, effectively reducing aggressive behavior and improving sleep quality.

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Section: Introductionmentioning

confidence: 99%

Effects of cognitive training and behavior modification on aggressive behavior and sleep quality in schizophrenia

Wang,

Cheng,

et al. 2024

Front. Psychiatry

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“…Major depression has been identified in one third of the schizophrenia patients and remains underdiagnosed and poorly treated (Fond et al 2018;Etchecopar-Etchart et al 2021). Second, sleep disorders are identified in more than an half of schizophrenia patients and may also favour motivation deficits (Meyer et al 2020;Sunhary de Verville et al 2021). Third, chronic inflammation has been identified in two thirds of patients with schizophrenia (Fond et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Precision-medicine findings from the FACE-SZ cohort to develop motivation-enhancing programs in real-world schizophrenia

Korchia

Tastevin

Pl³

et al. 2022

The World Journal of Biological Psychiatry

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Background: In people with schizophrenia, major areas of everyday life are impaired, including independent living, productive activities, social relationships and overall quality of life. Enhanced understanding of factors that hinder real-life functioning is vital for treatments to translate into more positive outcomes. Aim: The goal of the present study was to identify factors associated with motivation deficits in real-life schizophrenia, and to assess its contribution to impaired functioning and quality of life. Methods: Based on previous literature and clinical experience, several factors were selected and grouped into factors potentially explaining motivation deficits. Some of these variables were never investigated before in relationship with motivation deficits. Results: In 561 patients with schizophrenia of the national FACE-SZ cohort living in the community, 235 (41.9%) reported severe motivation deficits. These deficits were found to be significantly associated with impaired socially useful activities, psychological and physical quality of life (in almost all domains), alcohol use disorder (aOR ¼ 2.141, p ¼ 0.021), severe nicotine dependence (aOR ¼ 2.906, p < 0.001) independently of age and sex. No significant association was found for body mass index, metabolic syndrome or physical activity level. In the second model, we identified the following modifiable factors associated with motivation deficits: history of suicide attempt (aOR ¼ 2.297, p ¼ 0.001), positive symptoms (aOR ¼ 1.052, p ¼ 0.006), current major depressive episode (aOR ¼ 2.627, p < 0.001), sleep disorders (aOR ¼ 1.474, p ¼ 0.024) and lower medication adherence (aOR ¼ 0.836, p ¼ 0.001) independently of gender, current alcohol use disorder, second-generation antipsychotics and akathisia. No significant association was found for negative symptoms, childhood trauma and inflammation. These results were maintained after removing patients with schizoaffective disorders or those with major depressive disorder. Interpretation: Motivation deficits are frequent and remain persistent unmet need in real-world schizophrenia that should be addressed in future guidelines. Based on our results, literature and clinical experience, we recommend to address in priority major depression, sleep, suicide, positive symptoms (when present and as early as possible) and medication adherence to improve motivation deficits of schizophrenia.

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Autism Spectrum Disorder

Greydanus

Patel

Rowland

2022

Comprehensive Pharmacology

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Recommendations of the schizophrenia expert center network for the screening prevention and treatment of sleep disorders based on the results from the real-world schizophrenia FACE-SZ national cohort

Cited by 4 publications

References 67 publications

Effects of cognitive training and behavior modification on aggressive behavior and sleep quality in schizophrenia

Effects of cognitive training and behavior modification on aggressive behavior and sleep quality in schizophrenia

Precision-medicine findings from the FACE-SZ cohort to develop motivation-enhancing programs in real-world schizophrenia

Autism Spectrum Disorder

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