Beyond somatosensation: Mrgprs in mucosal tissues

Inclan-Rico, Juan M.; Kim, Brian; Abdus-Saboor, Ishmail

doi:10.1016/j.neulet.2021.135689

Cited by 10 publications

(7 citation statements)

References 67 publications

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“…Collectively, these studies advanced the concept that itch could be triggered in the periphery via dedicated receptors and neurons (i.e., pruriceptors) as observed in the spinal cord itself. Indeed, investigating the role of various Mrgprs in itch and even visceral sensory processes is a major field of inquiry (Inclan-Rico et al, 2021). Thus, the development of antagonists for these pathways is a new area of pharmaceutical development not only for itch but a variety of sensory disorders across multiple barrier surfaces.…”

Section: The Emergence Of Itchmentioning

confidence: 99%

“…Although these nerves have been classically considered distinct from the afferent nerves located in the DRG, new scRNA-seq studies suggest that subsets of jugular/nodose neurons closely resemble itchsensory neurons (Kupari et al, 2019). Indeed, Mrgprs, originally associated with pruriceptors, appear to have important functions on afferent nerves that innervate the lung and gut as well (Inclan-Rico et al, 2021). Thus, discoveries that are central to itch in the skin may inform diseases beyond itch and even lead to novel therapeutic treatments of even cardiac, gastrointestinal, and pulmonary diseases.…”

Section: Itch As a Broader Paradigm Of Neuroimmunological Disordersmentioning

confidence: 99%

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The translational revolution of itch

Kim

2022

Neuron

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Section: The Emergence Of Itchmentioning

confidence: 99%

Section: Itch As a Broader Paradigm Of Neuroimmunological Disordersmentioning

confidence: 99%

The translational revolution of itch

Kim

2022

Neuron

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“…MCs express a variety of neuron-related receptors, transmitters and peptides, such as Ach, substance P, and CGRP among others ( 189 ). Recent studies have also highlighted a pivotal role of Mas-related G-protein-coupled receptors (Mrgprs) in neuro-immune crosstalk ( 188 , 190 ). Mrgprs are highly expressed in MCs and are reported to mediate MC degranulation in an IgE-independent manner ( 191 , 192 ).…”

Section: Neuro-immune Communication During Helminth Infectionsmentioning

confidence: 99%

Communication is key: Innate immune cells regulate host protection to helminths

et al. 2022

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Parasitic helminth infections remain a significant global health issue and are responsible for devastating morbidity and economic hardships. During infection, helminths migrate through different host organs, which results in substantial tissue damage and the release of diverse effector molecules by both hematopoietic and non-hematopoietic cells. Thus, host protective responses to helminths must initiate mechanisms that help to promote worm clearance while simultaneously mitigating tissue injury. The specialized immunity that promotes these responses is termed type 2 inflammation and is initiated by the recruitment and activation of hematopoietic stem/progenitor cells, mast cells, basophils, eosinophils, dendritic cells, neutrophils, macrophages, myeloid-derived suppressor cells, and group 2 innate lymphoid cells. Recent work has also revealed the importance of neuron-derived signals in regulating type 2 inflammation and antihelminth immunity. These studies suggest that multiple body systems coordinate to promote optimal outcomes post-infection. In this review, we will describe the innate immune events that direct the scope and intensity of antihelminth immunity. Further, we will highlight the recent progress made in our understanding of the neuro-immune interactions that regulate these pathways and discuss the conceptual advances they promote.

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“…Is there a role for non-peptidergic neurons in helminth infection?. There are sensory afferents traditionally classified as "nonpeptidergic" found in the skin, 153 NG, and the enteric nervous system, 154 which are only now being explored in terms of their ability to modulate local immune responses. A large subset of these "non-peptidergic" afferents express members of the Masrelated G protein coupled receptor (Mrgpr) family, which transmit itch sensation, contribute to both skin mechanical pain and visceral pain, and modulation of gut motility.…”

Section: Helminth Clearance Is Regulated By Neuroendocrine Cells Neur...mentioning

confidence: 99%

“Every cell is an immune cell; contributions of non-hematopoietic cells to anti-helminth immunity”

Rossi

Herbert

2022

Mucosal Immunology

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Helminths are remarkably successful parasites that can invade various mammalian hosts and establish chronic infections that can go unnoticed for years despite causing severe tissue damage. To complete their life cycles, helminths migrate through multiple barrier sites that are densely populated by a complex array of hematopoietic and non-hematopoietic cells. While it is clear that type 2 cytokine responses elicited by immune cells promote worm clearance and tissue healing, the actions of non-hematopoietic cells are increasingly recognized as initiators, effectors and regulators of anti-helminth immunity. This review will highlight the collective actions of specialized epithelial cells, stromal niches, stem, muscle and neuroendocrine cells as well as peripheral neurons in the detection and elimination of helminths at mucosal sites. Studies dissecting the interactions between immune and nonhematopoietic cells will truly provide a better understanding of the mechanisms that ensure homeostasis in the context of helminth infections.

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Beyond somatosensation: Mrgprs in mucosal tissues

Cited by 10 publications

References 67 publications

The translational revolution of itch

The translational revolution of itch

Communication is key: Innate immune cells regulate host protection to helminths

“Every cell is an immune cell; contributions of non-hematopoietic cells to anti-helminth immunity”

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