Repeated crack cocaine administration alters panic-related responses and delta FosB immunoreactivity in panic-modulating brain regions

Effects of long-term social isolation on central, behavioural and metabolic parameters in middle-aged mice

“…ΔFosB is a transcription factor whose expression throughout the brain is modulated by chronic exposure to stress and a variety of other stimuli [36] . It is widely used as a marker of neuronal activity since it remains stable for long periods of time when compared to other neuronal activation markers [34] . Moreover, ΔFosB has been shown to regulate synaptic plasticity and behaviour [36] .…”

“…However, only a few studies have dealt with this issue so far in a mechanistic approach, mainly due to the lack of a proper animal model [32] . Tools like ΔFosB and BDNF are a great ally in studies that explores parameters of neuronal activation [34] and neuroplasticity [35] , respectively. Furthermore, previous studies reported the role of both in memory [36] , [37] .…”