Effect of low‐intensity extracorporeal shock wave therapy on diabetic erectile dysfunction: Randomised control trial

Shendy, Wael; Elsoghier, Omar M; Semary, Moataz; Ahmed, Abdelrazak A; Ali, Atef Fathi; Saber-Khalaf, Mohammed

doi:10.1111/and.13997

Cited by 18 publications

(10 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study by Gruenwald et al ., 25 the number of DM patients was 21 (72.4%), and their level of ED was not classified according to IIEF-5 scores. In a recent study conducted by Shendy et al ., 28 a significant increase in the IIEF-EF scores of patients with vasculogenic and neurogenic ED due to DM in the 3 rd month post-Li-ESWT was reported.…”

Section: Discussionmentioning

confidence: 90%

Is Li-ESWT effective in diabetic patients with severe erectile dysfunction?

Ergün¹,

Akyüz²

2022

Asian Journal of Andrology

View full text Add to dashboard Cite

Noninvasive low-intensity extracorporeal shockwave treatment (Li-ESWT) has been widely used to treat erection disorders. There is no clear information regarding either the selection of patients for the treatment or the treatment protocol. In this study, we aimed to investigate the efficacy of extracorporeal shockwave therapy in diabetic patients with severe erectile dysfunction (International Index of Erectile Function-5 [IIEF-5] scores of 5 to 7). Sixty-three diabetes mellitus patients with erectile dysfunction having IIEF-5 scores of 5 to 7 and not showing a recovery of potency despite phosphodiesterase type 5 inhibitor therapy for the past 6 months were included in the study. The patients were evaluated based on their IIEF-5 scores and Erection Hardness Scale scores. The IIEF-5 score (mean ± standard deviation [s.d.]) increased from 5.29 ± 1.67 to 5.56 ± 1.85, with a difference of 0.27 ± 0.18 ( P > 0.05). The Erection Hardness Scale scores (mean ± s.d.), on the other hand, increased from 1.46 ± 0.50 to 1.48 ± 0.50, with a difference of 0.02 ± 0 ( P > 0.05). In conclusion, the response to phosphodiesterase type 5 inhibitors did not change after extracorporeal shockwave treatment in diabetes mellitus patients with severe erectile dysfunction (IIEF-5 scores of 5 to 7).

show abstract

Section: Discussionmentioning

confidence: 90%

Is Li-ESWT effective in diabetic patients with severe erectile dysfunction?

Ergün¹,

Akyüz²

2022

Asian Journal of Andrology

View full text Add to dashboard Cite

show abstract

“…Of the remaining 39 articles, 23 articles were excluded because they are not RCT or lack of effective data. Finally, the remaining 16 articles were included in the study to evaluate the effectiveness of LI-ESWT in the treatment of ED ( Baccaglini et al, 2020 ; Fojecki et al, 2017 ; Kalyvianakis & Hatzichristou, 2017 ; Kim et al, 2020 ; Kitrey et al, 2016 ; Ladegaard et al, 2021 ; Olsen et al, 2015 ; Ortac et al, 2021 ; Shendy et al, 2021 ; Sramkova et al, 2020 ; Srini et al, 2015 ; Vardi et al, 2012 ; Vinay et al, 2021 ; Yamaçake et al, 2019 ; Yee et al, 2014 ; Zewin et al, 2018 ). The details of each study are presented in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

Systematic Review and Meta-Analysis of 16 Randomized Controlled Trials of Clinical Outcomes of Low-Intensity Extracorporeal Shock Wave Therapy in Treating Erectile Dysfunction

et al. 2022

View full text Add to dashboard Cite

We conducted a meta-analysis to evaluate the efficacy of low-intensity extracorporeal shock wave therapy (LI-ESWT) in the treatment of erectile dysfunction (ED). From July 2011 to June 2021, we finally selected 16 randomized controlled trials (RCTs) including 1,064 participants to evaluate the efficacy of LI-ESWT in the treatment of ED from PubMed, EMBASE, and Cochrane databases. The data are analyzed by Review Manager Version 5.4. Fifteen articles mentioned International Index of Erectile Function (IIEF), in the follow-up of 1 month (mean difference [MD] = 3.18, 95% confidence interval [CI] = [1.38, 4.98], p = .0005), 3 months (MD = 3.01, 95% CI = [2.04, 3.98], p < .00001), and 6 months (MD = 3.20, 95% CI = [2.49, 3.92], p < .00001). After treatment, the improvement of IIEF in the LI-ESWT group was better than that in the control group. Besides, eight of the 16 trials provided data on the proportion of patients with baseline Erectile Hardness Score (EHS) ≤ 2 improved to EHS ≥ 3. The LI-ESWT group was also significantly better than the placebo group (odds ratio [OR] = 5.07, 95% CI = [1.78, 14.44], p = .002). The positive response rate of Questions 2 and 3 of the Sexual Encounter Profile (SEP) was not statistically significant (SEP2: OR = 1.27, 95% CI = [0.70, 2.30], p = .43; SEP3: OR = 4.24, 95% CI = [0.67, 26.83], p = .13). The results of this meta-analysis suggest that treatment plans with an energy density of 0.09 mJ/mm2 and pulses number of 1,500 to 2,000 are more beneficial to IIEF in ED patients. In addition, IIEF improvement was more pronounced in patients with moderate ED after extracorporeal shockwave therapy.

show abstract

“…Gene therapy is also a new direction. Target genes such as vascular nerve regeneration factor [51] and insulin-like growth factor 1 (IGF-1) [52] are signi cantly downregulated in patients with advanced DMED, and repair therapy with these genes also improved erectile function. In addition, low-intensity extra corporeal shock wave therapy (Li-ESWT) for DMED is also a topic of interest in current research, which is a non-invasive therapy with few side effects that can be used as a treatment option for patients with a poor response to oral drugs [53].…”

Section: Hotspots and Frontiersmentioning

confidence: 99%

Current Status and Prospects of Diabetes Mellitus Induced Erectile Dysfunction: A Bibliometric and Visualization Study

Liu

Zhang

Bao

et al. 2022

Preprint

View full text Add to dashboard Cite

The prevalence of diabetes mellitus-induced erectile dysfunction (DMED) has recently increased, which has prompted numerous DMED studies. Here, we conduct a bibliometric analysis of relevant literature in the field of DMED and to discuss the research hotspots and future development directions. The Web of Science Core Collection database was searched for literature on DMED, and literature characterization was performed using VOS viewer 1.6.18 and CiteSpace 5.8 R3 software. A total of 804 articles concerning DMED were included in this study. The Journal of Sexual Medicine issued the most documents. The United States and China were in the leading position in the field of DMED research. Ryu JK were the authors with the highest number of documents issued while Bivalacqua TJ was the author with the most co-citated. The keywords analysis shows that the main research hotspots in the field of DMED were mechanism discussions and disease treatment and management. Global research on DMED is expected to increase further. The investigation of the mechanism of DMED and the exploration of new therapeutic means and targets are the focus of future research.

show abstract

Effect of low‐intensity extracorporeal shock wave therapy on diabetic erectile dysfunction: Randomised control trial

Cited by 18 publications

References 29 publications

Is Li-ESWT effective in diabetic patients with severe erectile dysfunction?

Is Li-ESWT effective in diabetic patients with severe erectile dysfunction?

Systematic Review and Meta-Analysis of 16 Randomized Controlled Trials of Clinical Outcomes of Low-Intensity Extracorporeal Shock Wave Therapy in Treating Erectile Dysfunction

Current Status and Prospects of Diabetes Mellitus Induced Erectile Dysfunction: A Bibliometric and Visualization Study

Contact Info

Product

Resources

About