Lesser Investigated Natural Ingredients for the Management of Obesity

Majeed, Muhammed; Majeed, Shaheen; Nagabhushanam, Kalyanam; Gnanamani, Muthuraman; Mundkur, Lakshmi

doi:10.3390/nu13020510

Cited by 8 publications

(3 citation statements)

References 129 publications

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“…Oral supplementation could affect the signals associated with lipid catabolism, lipolysis, mitochondria biogenesis, and uncoupling protein 1 (UCP1)-positive cells in the adipose tissues and contribute to managing obesity and metabolic syndrome [ 18 ]. The qPCR was performed to examine if RF feeding could regulate the lipid catabolism genes, including thermogenic signaling in the BAT, WAT, and liver.…”

Section: Resultsmentioning

confidence: 99%

Ribes fasciculatum Ameliorates High-Fat-Diet-Induced Obesity by Elevating Peripheral Thermogenic Signaling

et al. 2022

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Ribes fasciculatum has been consumed as a food and as a traditional medicine for treating autoimmune diseases and aging in diverse countries. A previous study showed that a mixture of Ribes fasciculatum and Cornus officinalis prohibited adipocyte differentiation and lipid accumulation in preadipocytes and suppressed diet-induced obesity. Nevertheless, the mechanism of R. fasciculatum to regulate energy homeostasis solely through thermogenic signaling remains unclear. Thus, we investigated its effects on energy homeostasis using R. fasciculatum fed to C57BL/6 mice with a 45% high-fat diet. Chronic consumption of R. fasciculatum decreased the body weight of obese mice with increasing food intakes and improved metabolic-syndrome-related phenotypes. Therefore, we further tested its thermogenic effects. Cold chamber experiments and qPCR studies indicated that R. fasciculatum elevated thermogenic signaling pathways, demonstrated by increased body temperature and uncoupling protein 1 (UCP1) signaling in the white and brown adipose tissues. Afzelin is one major known compound derived from R. fasciculatum. Hence, the isolated compound afzelin was treated with preadipocytes and brown adipocytes for cell viability and luciferase assay, respectively, to further examine its thermogenic effect. The studies showed that the response of afzelin was responsible for cell viability and the increased UCP1. In conclusion, our data indicated that R. fasciculatum elevated peripheral thermogenic signaling through increased UCP1 via afzelin activation and ameliorated diet-induced obesity.

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Section: Resultsmentioning

confidence: 99%

Ribes fasciculatum Ameliorates High-Fat-Diet-Induced Obesity by Elevating Peripheral Thermogenic Signaling

et al. 2022

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“…The increase of free fatty acids and chronic overnutrition seem to induce lipotoxicity and endoplasmic reticulum stress. This inflammatory response might contribute to a blunted physiological response to leptin in obesity [ 60 ] even if overweight individuals have a higher circulating leptin level [ 61 ] throughout the circadian rhythm [ 62 ]. However, the daily variations in overweight individuals are smaller than those in normal-weight individuals.…”

Section: Discussionmentioning

confidence: 99%

Leptin as a Biomarker of Stress: A Systematic Review and Meta-Analysis

Bouillon‐Minois

Trousselard²,

Torgerson

et al. 2021

Nutrients

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Background: Leptin is a satiety hormone mainly produced by white adipose tissue. Decreasing levels have been described following acute stress. Objective: To conduct a systematic review and meta-analysis to determine if leptin can be a biomarker of stress, with levels decreasing following acute stress. Methods: PubMed, Cochrane Library, Embase, and ScienceDirect were searched to obtain all articles studying leptin levels after acute stress on 15 February 2021. We included articles reporting leptin levels before and after acute stress (physical or psychological) and conducted random effects meta-analysis (DerSimonian and Laird approach). We conducted Meta-regressions and sensitivity analyses after exclusion of groups outside the metafunnel. Results: We included seven articles—four cohort and three case-control studies—(28 groups) from 27,983 putative articles. Leptin levels decreased after the stress intervention (effect size = −0.34, 95%CI −0.66 to −0.02) compared with baseline levels, with a greater decrease after 60 min compared to mean decrease (−0.45, −0.89 to −0.01) and in normal weight compared to overweight individuals (−0.79, −1.38 to −0.21). There was no difference in the overweight population. Sensitivity analyses demonstrated similar results. Levels of leptin after stress decreased with sex ratio—i.e., number of men/women—(−0.924, 95%CI −1.58 to −0.27) and increased with the baseline levels of leptin (0.039, 0.01 to 0.07). Conclusions: Leptin is a biomarker of stress, with a decrease following acute stress. Normal-weight individuals and women also have a higher variation of leptin levels after stress, suggesting that leptin may have implications in obesity development in response to stress in a sex-dependent manner.

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“…The ethyl acetate extract of dried, pulverized rhizomes of C. rotundus was reported to contain Scirpusin A, Scirpusin B & Piceatannol as major compounds [6]. The chloroform/methyl alcohol extraction of C. rotundus yielded novel enantiomeric and meso-stilbene trimers, such as Cyperusphenol A as well as other stilbenoids (Cyperusphenol C & D, Scirpusins A & B, Piceid and Luteolin [7].…”

Section: Anti-obesity Mechanism Of Cyperus Rotundusmentioning

confidence: 99%

Cyperus Rotundus and its Anti-Obesity Effect in Swiss Albino Mice

Tripathi

2022

ARR

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Cyperus rotundus also known as 'Nutgrass' have been used in Ayurveda and in Traditional Chinese medicinal practices for its multiple medicinal property. Since obesity is major factor for the increase in the metabolic syndrome related complication. We have used Cyperus rotundus methanolic extract in mice along with the High fat diet. As compared to only high fat diet group, Cyperus rotundus administered high fat diet showed significant weight reduction along with reduced triglycerides and cholesterol level. Cyperus rotundus also acted on inflammation, reducing the TNF alpha level in mice fed with Cyperus rotundus along with the high fat diet. This was also connected to the level of reduction in the mRNA expression of COX-2 in the visceral fat of the mice.

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Lesser Investigated Natural Ingredients for the Management of Obesity

Cited by 8 publications

References 129 publications

Ribes fasciculatum Ameliorates High-Fat-Diet-Induced Obesity by Elevating Peripheral Thermogenic Signaling

Ribes fasciculatum Ameliorates High-Fat-Diet-Induced Obesity by Elevating Peripheral Thermogenic Signaling

Leptin as a Biomarker of Stress: A Systematic Review and Meta-Analysis

Cyperus Rotundus and its Anti-Obesity Effect in Swiss Albino Mice

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