Histiocytic sarcoma with brainstem and spinal canal involvement detected by [18F]-FDG PET/CT

Herrera‐Martínez, Yiraldine; Fernández-Rodríguez, Paula; Alba, Carmen María Del Prado; Acevedo-Báñez, I.

doi:10.1093/jjco/hyaa267

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2023

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“…It may appear up to 17 years after the initial malignancy [1][2][3]. There are very few cases of extranodal HS with 18 F-FDG PET/CT findings in the literature [4][5][6][7][8]. However, we are unaware of the 18 F-FDG PET/CT findings in extranodal HS arising after large B-cell lymphoma.…”

Section: Institutional Review Board Statementmentioning

confidence: 99%

Enhanced Computed Tomography and 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Uncommon Histiocytic Sarcoma of Small Intestine Arising after Gastric Large B-Cell Lymphoma

Cheon,

Yoo,

Kim

et al. 2023

Diagnostics

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Histiocytic sarcoma (HS) is an extremely rare and aggressive malignant neoplasm of hematopoietic origin that shows morphologic and immunophenotypic evidence of histiocytic differentiation. In approximately 25% of the cases, presumed transdifferentiation of a preexisting hematolymphoid disorder can be demonstrated. Various extranodal sites, particularly the gastrointestinal tract, soft tissue, skin, and spleen, can be involved. Enhanced CT and FDG PET/CT findings of extranodal histiocytic sarcoma have been barely reported. We present a case with extranodal HS originating in the small intestine after gastric large B-cell lymphoma, mistaken for prostate cancer metastasis in a 76-year-old man.

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