Health disparities: Intracellular consequences of social determinants of health

Emeny, Rebecca T.; Carpenter, David O.; Lawrence, David A.

doi:10.1016/j.taap.2021.115444

Cited by 31 publications

(25 citation statements)

References 159 publications

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“…Sex differences in antioxidant defense, metabolizing enzymes, and placental responses also may play a role [ 49 ]. Effect modification by race/ethnicity may reflect increased oxidative stress documented among minoritized groups, particularly Blacks [ 50 ]. Future work is needed to elucidate mechanisms underlying the observed associations.…”

Section: Discussionmentioning

confidence: 99%

Prenatal Fine Particulate Matter, Maternal Micronutrient Antioxidant Intake, and Early Childhood Repeated Wheeze: Effect Modification by Race/Ethnicity and Sex

et al. 2022

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Fine particulate matter (PM2.5) potentiates in utero oxidative stress influencing fetal development while antioxidants have potential protective effects. We examined associations among prenatal PM2.5, maternal antioxidant intake, and childhood wheeze in an urban pregnancy cohort (n = 530). Daily PM2.5 exposure over gestation was estimated using a satellite-based spatiotemporally resolved model. Mothers completed the modified Block98 food frequency questionnaire. Average energy-adjusted percentile intake of β-carotene, vitamins (A, C, E), and trace minerals (zinc, magnesium, selenium) constituted an antioxidant index (AI). Maternal-reported child wheeze was ascertained up to 4.1 ± 2.8 years. Bayesian distributed lag interaction models (BDLIMs) were used to examine time-varying associations between prenatal PM2.5 and repeated wheeze (≥2 episodes) and effect modification by AI, race/ethnicity, and child sex. Covariates included maternal age, education, asthma, and temperature. Women were 39% Black and 33% Hispanic, 36% with ≤high school education; 21% of children had repeated wheeze. Higher AI was associated with decreased wheeze in Blacks (OR = 0.37 (0.19–0.73), per IQR increase). BDLIMs identified a sensitive window for PM2.5 effects on wheeze among boys born to Black mothers with low AI (at 33–40 weeks gestation; OR = 1.74 (1.19–2.54), per µg/m3 increase in PM2.5). Relationships among prenatal PM2.5, antioxidant intake, and child wheeze were modified by race/ethnicity and sex.

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Section: Discussionmentioning

confidence: 99%

Prenatal Fine Particulate Matter, Maternal Micronutrient Antioxidant Intake, and Early Childhood Repeated Wheeze: Effect Modification by Race/Ethnicity and Sex

et al. 2022

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“…Further, inflammation and DNA-methylation alterations are environmentally-sensitive hallmarks of biological aging [46][47][48] . We found that body mass index largely accounted for associations of DNAm-CRP and DunedinPoAm with mental health, which corresponds to new insights casting obesity as an inflammatory disease of accelerated biological aging 49 .…”

Section: Discussionmentioning

confidence: 99%

Socially stratified DNA-methylation profiles are associated with disparities in child and adolescent mental health

Raffington

Tanksley

Vinnik

et al. 2021

Preprint

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Importance: Economic and racial inequality is linked to disparities in children's mental health. Biomarkers that reflect these social disparities are lacking. Objective: We examined the hypothesis that salivary DNA-methylation patterns of higher inflammation and faster pace of biological aging are economically, racially and ethnically stratified and are associated with child mental health. Design: The Texas Twin Project is an on-going, observational, longitudinal study that began in May 2012. Analyses were preregistered on May 7, 2021, and completed on August 23, 2021. Setting: The population-based study identified and recruited participants from public school rosters in the greater Austin area. Participants: Participants in the analytic data set included all participants that agreed to contribute DNA samples and whose samples were assayed by January 2021. Exposures: Family- and neighborhood-level socioeconomic inequality, racial and ethnic identities (White, Latinx, Black, Asian). Main Measure(s): Environmental exposures were analyzed in relation to salivary DNA-methylation profiles of higher inflammation (DNAm-CRP) and faster pace of biological aging (DunedinPoAm). Child internalizing problems, attention problems, aggression, rule-breaking, ADHD, oppositional defiant disorder, and conduct disorder were measured using parent-reports and self-reports on abbreviated versions of the Achenbach Child Behavior Checklist and Conners 3. The hypotheses being tested were formulated after data collection of the present data freeze and were pre-registered prior to analyses being conducted. Results: In a sample of N=1,183 8-to-19-year-olds (609 female, age M=13.38y), children's salivary DNA-methylation profiles and psychiatric symptoms differed by socioeconomic conditions, race and ethnicity. Children with more parent-reported internalizing symptoms had higher DNAm-CRP (r=0.15, 95% CI=0.05 to 0.25, P=0.004) and DunedinPoAm (r=0.15, CI=0.05 to 0.25, P=0.002), and children with more parent-reported aggression problems had higher DNAm-CRP (r=0.17, CI=0.04 to 0.31, P=0.013). DNAm-CRP partially mediated advantage of higher family socioeconomic status (16% of total effect) and White racial identity (12% of total effect) on reduced internalizing symptoms. DunedinPoAm also partially mediated advantage of White racial identity on internalizing (19% of total effect). Conclusions and Relevance: Socioeconomic and racial inequality are visible in children's epigenetic profiles of inflammation and the rate of biological aging in a manner that is tied to social disparities in mental health.

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“…Figure 1 summarizes immunogenetic factors discussed in the present review [202][203][204][205][206][207][208][209][210][211][212][213]. refers to habits (in terms of quality of nutrition, physical activity, drug consumption, smoking) and to socio-economic parameters (access to the health care system, level of education, access to high quality medical information), i.e., the social determinants of health.…”

Section: Other Genetic Determinants Of Establishment/maintenance/resolution Of the Immune Response And Antigen Presentationmentioning

confidence: 99%

“…"Lifestyle" refers to habits (in terms of quality of nutrition, physical activity, drug consumption, smoking) and to socio-economic parameters (access to the health care system, level of education, access to high quality medical information), i.e., the social determinants of health. "Environment" (intended as exposure to contaminants, pollution, and non-ionizing radio frequency, but also as exposure to multiple pathogens) is relevant since it mechanistically modifies the immune response[202][203][204][205][206][207][208][209][210]. Viral genetic variants and their effects on virulence/COVID-19 severity are also a matter of intense research[211][212][213].…”

mentioning

confidence: 99%

The Role of Immunogenetics in COVID-19

Pojero

Candore

Caruso

et al. 2021

IJMS

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Coronavirus disease 2019 (COVID-19) is induced by SARS-CoV-2 and may arise as a variety of clinical manifestations, ranging from an asymptomatic condition to a life-threatening disease associated with cytokine storm, multiorgan and respiratory failure. The molecular mechanism behind such variability is still under investigation. Several pieces of experimental evidence suggest that genetic variants influencing the onset, maintenance and resolution of the immune response may be fundamental in predicting the evolution of the disease. The identification of genetic variants behind immune system reactivity and function in COVID-19 may help in the elaboration of personalized therapeutic strategies. In the frenetic look for universally shared treatment plans, those genetic variants that are common to other diseases/models may also help in addressing future research in terms of drug repurposing. In this paper, we discuss the most recent updates about the role of immunogenetics in determining the susceptibility to and the history of SARS-CoV-2 infection. We propose a narrative review of available data, speculating about lessons that we have learnt from other viral infections and immunosenescence, and discussing what kind of aspects of research should be deepened in order to improve our knowledge of how host genetic variability impacts the outcome for COVID-19 patients.

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Health disparities: Intracellular consequences of social determinants of health

Cited by 31 publications

References 159 publications

Prenatal Fine Particulate Matter, Maternal Micronutrient Antioxidant Intake, and Early Childhood Repeated Wheeze: Effect Modification by Race/Ethnicity and Sex

Prenatal Fine Particulate Matter, Maternal Micronutrient Antioxidant Intake, and Early Childhood Repeated Wheeze: Effect Modification by Race/Ethnicity and Sex

Socially stratified DNA-methylation profiles are associated with disparities in child and adolescent mental health

The Role of Immunogenetics in COVID-19

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